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Different types of adjuvants in prophylactic and therapeutic human papillomavirus vaccines in laboratory animals: a systematic review

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Abstract

Human papillomavirus (HPV) causes cervical carcinoma, which and is the third most common cancer, accounting for 275,000 deaths annually worldwide. Adjuvants have a key role in promotion of vaccine efficacy; therefore, using prophylactic and therapeutic vaccines combined with adjuvant could be of great benefit in prevention and treatment of cervical cancer. There are different types of adjuvants, including MF59TM adjuvants, RNA-based, JY (interleukin2/chitosan), cholera toxin (CT), heat-labile enterotoxin (LT), Freund’s adjuvant, alum, SA-4-1BBL, λ-carrageenan (λ-CGN), heat shock proteins (HSPs), juzen-taiho-to (JTT) and hochu-ekki-to (HET), ISCOM and ISCOMATRIX™, very small size proteoliposomes (VSSPs), granulocyte macrophage colony-stimulating factor (GM-CSF), and Toll-like receptors (TLRs). Adjuvants have various functions, especially in therapeutic vaccines, and they lead to an increase in cytotoxic T lymphocytes (CTLs), so they are important in the design of vaccines. Here, we review the currently used adjuvants and their combinations with HPV protein vaccines in order to introduce an appropriate adjuvant for HPV vaccines.

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Authors and Affiliations

  1. Molecular and Cell Biology, Student Research Committee, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Tahoora Mousavi

  2. Department of Biology, Faculty of Basic Science, Shahed University, Tehran, Iran

    Sogol Sattari Saravi

  3. Molecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Reza Valadan & Alireza Rafiei

  4. Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Reza Valadan & Alireza Rafiei

  5. Department of Microbiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Mohammad Reza Haghshenas

  6. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Hamed Jafarpour

  7. Department of Medical Laboratory Sciences, Student Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

    Amir Shamshirian

  8. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran

    Amir Shamshirian

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  1. Tahoora Mousavi
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Mousavi, T., Sattari Saravi, S., Valadan, R. et al. Different types of adjuvants in prophylactic and therapeutic human papillomavirus vaccines in laboratory animals: a systematic review. Arch Virol 165, 263–284 (2020). https://doi.org/10.1007/s00705-019-04479-4

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