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Giant viral genomic signatures in the previously reported gut metagenomes of pre-school children in rural India

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Abstract

A recent study by Ghosh et al. compared the gut microbiomes of 20 preschool children from India and found an association between the gut microbiome and the nutritional status of the child. Here, we explored these metagenomes for the presence of genomic signatures of prokaryotic and eukaryotic viruses. Several of the viral signatures found in all 20 metagenomes belonged to giant viruses (GVs). In addition, we found hits for bacteriophages to several major human pathogens, including Shigella, Salmonella, Escherichia, and Enterobacter. Concurrently, we also detected several antibiotic resistance genes (ARGs) in the metagenomes. All of the ARGs detected in this study (beta-lactam, macrolide, metronidazole, and tetracycline) are associated with mobile genetic elements (MGEs) and have been reported to cause high levels of resistance to their respective antibiotics. Despite recent reports of giant viruses and their genomic signatures in gut microbiota, their role in human physiology remains poorly understood. The effect of cooccurrence of ARGs and GVs in the gut needs further investigation.

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India

    Anirvan Chatterjee & Kiran Kondabagil

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  1. Anirvan Chatterjee
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  2. Kiran Kondabagil
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Correspondence to Kiran Kondabagil.

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Chatterjee, A., Kondabagil, K. Giant viral genomic signatures in the previously reported gut metagenomes of pre-school children in rural India. Arch Virol 164, 2819–2822 (2019). https://doi.org/10.1007/s00705-019-04387-7

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