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Comparative genomic analysis of novel bacteriophages infecting Vibrio parahaemolyticus isolated from western and southern coastal areas of Korea

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Abstract

Vibrio parahaemolyticus, a foodborne pathogen, has become resistant to antibiotics. Therefore, alternative bio-control agents such bacteriophage are urgently needed for its control. Six novel bacteriophages specific to V. parahaemolyticus (vB_VpaP_KF1~2, vB_VpaS_KF3~6) were characterized at the molecular level in this study. Genomic similarity analysis revealed that these six bacteriophages could be divided into two groups with different genomic features, phylogenetic grouping, and morphologies. Two groups of bacteriophages had their own genes with different mechanisms for infection, assembly, and metabolism. Our results could be used as a future reference to study phage genomics or apply phages in future bio-control studies.

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Funding

This study was supported by the Main Research Program (E0152203-03) of the Korea Food Research Institute, funded by the Ministry of Science and ICT. It was also supported by a grant (CRC-16-01-KRICT) from the National Research Council of Science & Technology (NST) fund by the Korea government (MSIP).

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Authors and Affiliations

  1. Food Safety Research Group, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea

    Junhyeok Yu, Jeong-A Lim, Su-Jin Kwak & Hyun-Joo Chang

  2. Department of Food and Biotechnology, Gachon University, Sungnam, 13120, Republic of Korea

    Junhyeok Yu & Jong-Hyun Park

  3. Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, 141, Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea

    Hyun-Joo Chang

Authors
  1. Junhyeok Yu
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  2. Jeong-A Lim
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  3. Su-Jin Kwak
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  4. Jong-Hyun Park
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  5. Hyun-Joo Chang
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Corresponding author

Correspondence to Hyun-Joo Chang.

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All authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Handling Editor: T. K. Frey.

The nucleotide sequence data reported herein are available in the GenBank database under the accession numbers MF754111, MF754112, MF754113, MF754114, MF754115, MF754116.

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Yu, J., Lim, JA., Kwak, SJ. et al. Comparative genomic analysis of novel bacteriophages infecting Vibrio parahaemolyticus isolated from western and southern coastal areas of Korea. Arch Virol 163, 1337–1343 (2018). https://doi.org/10.1007/s00705-018-3756-3

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  • DOI: https://doi.org/10.1007/s00705-018-3756-3

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