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The genome sequence of a novel simian adenovirus in a chimpanzee reveals a close relationship to human adenoviruses

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Abstract

Recently, several reports have revealed that some simian adenoviruses (AdVs) strains show a close relationship to human AdVs. In the present study, a simian AdV strain named SAdV-ch1 was detected in chimpanzees in China, and its complete genome was determined. Phylogenetic analysis revealed SAdV-ch1 clustering in a clade that was separate from all of the other simian AdVs but genetically close to a human AdV strain, HAdV-18 (GenBank no. GU191019), sharing 92.5 % sequence identity with it. Recombination analysis provided evidence that a recombination event had occurred between SAdV-ch1 and HAdV-61 (JF964962), where SAdV-ch1 exchanged partial of its hexon gene segment with HAdV-61, leading to the recombinant HAdV-31 (AM749299).

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Acknowledgement

This work was partly supported by China Postdoctoral Science Foundation No. 2013M531291 and 2013M530234, the National Natural Science Foundation of China No. 31302107, the Ph.D. Programs Foundation of the Ministry of Education of China No. 20113227120008, the Natural Science Foundation of Jiangsu Province no. BK2012289, the Special Fund for Preventive Medicine of Jiangsu Province no. Y2012067, and the Professional Research Foundation for Advanced Talents of Jiangsu University under grant no.12JDG085.

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Authors and Affiliations

  1. School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China

    Chenglin Zhou, Xiaochun Wang, Shixing Yang, Quan Shen, Yan Wang, Bin Ni, Shengxia Chen, Xingli Fu & Wen Zhang

  2. Department of Laboratory Medicine, The First People’s Hospital of Suqian, Suqian, 223800, Jiangsu, China

    Chenglin Zhou

  3. Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China

    Hua Tian

  4. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

    Wei Liu

  5. College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, China

    Rongmei Fei

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  1. Chenglin Zhou
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  2. Hua Tian
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  3. Xiaochun Wang
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  4. Wei Liu
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  7. Yan Wang
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  8. Bin Ni
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  9. Shengxia Chen
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  10. Xingli Fu
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  11. Rongmei Fei
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  12. Wen Zhang
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Corresponding authors

Correspondence to Rongmei Fei or Wen Zhang.

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C. Zhou and H. Tian contributed equally to this work.

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Zhou, C., Tian, H., Wang, X. et al. The genome sequence of a novel simian adenovirus in a chimpanzee reveals a close relationship to human adenoviruses. Arch Virol 159, 1765–1770 (2014). https://doi.org/10.1007/s00705-013-1967-1

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  • DOI: https://doi.org/10.1007/s00705-013-1967-1

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