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Effects of allitridin on acute and chronic mouse cytomegalovirus infection

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Abstract

This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo. The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo.

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Acknowledgments

This work was sponsored by a grant (no. 30572345) from the National Natural Science Foundation of China, awarded to Feng Fang.

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Authors and Affiliations

  1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xing-lou Liu, Hui Wang, Ya-nan Li, Hai-xia Ge, Sai-nan Shu & Feng Fang

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  1. Xing-lou Liu
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  2. Hui Wang
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  3. Ya-nan Li
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  4. Hai-xia Ge
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  5. Sai-nan Shu
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  6. Feng Fang
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Correspondence to Feng Fang.

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Liu, Xl., Wang, H., Li, Yn. et al. Effects of allitridin on acute and chronic mouse cytomegalovirus infection. Arch Virol 156, 1841–1846 (2011). https://doi.org/10.1007/s00705-011-1025-9

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  • DOI: https://doi.org/10.1007/s00705-011-1025-9

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