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Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C

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Abstract

Porcine endogenous retroviruses (PERVs) represent a risk for xenotransplantation using pig cells or organs since they are integrated in the genome of all pigs and infect human cells in vitro. Recombinants between PERV-A and PERV-C have been described in pigs in vivo and found de novo integrated in the genome of somatic cells, but not in the germ line. To study whether PERV-A/C can infect and have a pathogenic effect in normal pigs, German landrace pigs were inoculated with high-titre PERV-A/C. No provirus integration was found in blood cells or in various tissues, and no antibody production was observed, indicating the absence of infection.

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Authors and Affiliations

  1. Robert Koch Institute, Berlin, Germany

    D. Kaulitz, D. Mihica & J. Denner

  2. Paul Ehrlich Institute, Langen, Germany

    R. Plesker, A. Geissler & R. R. Tönjes

Authors
  1. D. Kaulitz
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  2. D. Mihica
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  3. R. Plesker
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  4. A. Geissler
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  5. R. R. Tönjes
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  6. J. Denner
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Correspondence to J. Denner.

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Kaulitz, D., Mihica, D., Plesker, R. et al. Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C. Arch Virol 156, 707–710 (2011). https://doi.org/10.1007/s00705-010-0896-5

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  • DOI: https://doi.org/10.1007/s00705-010-0896-5

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