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Prevalence of hepatitis E virus among swine and humans in two different ethnic communities in Indonesia

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Abstract

The purpose of this study was to investigate the prevalence of hepatitis E virus (HEV) infection in swine and humans in different environments in Java and Bali, Indonesia. The prevalence of anti-HEV antibodies in people over 20 years old living in communities in Bali was significantly higher than that in Java. While 68.8% and 90.0% of swine in Bali were anti-HEV positive at 1 and 2 months of age, respectively, swine in Java were at significantly lower risk of HEV infection by the age of 2 months. Our present data suggest that substantial differences in swine-breeding conditions and human living environments affect the rate of HEV infection in humans and swine.

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References

  1. Baechlein C, Schielke A, Johne R, Ulrich RG, Baumgaertner W, Grummer B (2010) Prevalence of hepatitis E virus-specific antibodies in sera of German domestic pigs estimated by using different assays. Vet Microbiol 144:187–191

    Article  PubMed  Google Scholar 

  2. Corwin A, Putri MP, Winarno J, Lubis I, Suparmanto S, Sumardiati A, Laras K, Tan R, Master J, Warner G, Wignall FS, Graham R, Hyams KC (1997) Epidemic and sporadic hepatitis E virus transmission in West Kalimantan (Borneo), Indonesia. Am J Trop Med Hyg 57:62–65

    PubMed  CAS  Google Scholar 

  3. Corwin A, Jarot K, Lubis I, Nasution K, Suparmawo S, Sumardiati A, Widodo S, Nazir S, Orndorff G, Choi Y et al (1995) Two years’ investigation of epidemic hepatitis E virus transmission in West Kalimantan (Borneo), Indonesia. Trans R Soc Trop Med Hyg 89:262–265

    Article  PubMed  CAS  Google Scholar 

  4. Dalton HR, Bendall R, Ijaz S, Banks M (2008) Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 8:698–709

    Article  PubMed  Google Scholar 

  5. Emerson SU, Purcell RH (2003) Hepatitis E virus. Rev Med Virol 13:145–154

    Article  PubMed  CAS  Google Scholar 

  6. Galiana C, Fernández-Barredo S, García A, Gómez MT, Pérez-Gracia MT (2008) Occupational exposure to hepatitis E virus (HEV) in swine workers. Am J Trop Med Hyg 78:1012–1015

    PubMed  Google Scholar 

  7. Hu WP, Lu Y, Precioso NA, Chen HY, Howard T, Anderson D, Guan M (2008) Double-antigen enzyme-linked immunosorbent assay for detection of hepatitis E virus-specific antibodies in human or swine sera. Clin Vaccine Immunol 15:1151–1157

    Article  PubMed  CAS  Google Scholar 

  8. Kanai Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K (2010) Long-term shedding of hepatitis E virus in the feces of pigs infected naturally, born to sows with and without maternal antibodies. J Med Virol 82:69–76

    Article  PubMed  CAS  Google Scholar 

  9. Ma Z, Feng R, Zhao C, Harrison TJ, Li M, Qiao Z, Feng Y, Wang Y (2010) Seroprevalence and distribution of hepatitis E virus in various ethnic groups in Gansu province, China. Infect Genet Evol 10:614–619

    Article  PubMed  Google Scholar 

  10. Okamoto H, Takahashi M, Nishizawa T, Fukai K, Muramatsu U, Yoshikawa A (2001) Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan. Biochem Biophys Res Commun 289:929–936

    Article  PubMed  CAS  Google Scholar 

  11. Rutjes SA, Lodder-Verschoor F, Lodder WJ, van der Giessen J, Reesink H, Bouwknegt M, de Roda Husman AM (2010) Seroprevalence and molecular detection of hepatitis E virus in wild boar and red deer in The Netherlands. J Virol Methods 168:197–206

    Article  PubMed  CAS  Google Scholar 

  12. Sedyaningsih-Mamahit ER, Larasati RP, Laras K, Sidemen A, Sukri N, Sabaruddin N, Didi S, Saragih JM, Myint KS, Endy TP, Sulaiman A, Campbell JR, Corwin AL (2002) First documented outbreak of hepatitis E virus transmission in Java, Indonesia. Trans R Soc Trop Med Hyg 96:398–404

    Article  PubMed  CAS  Google Scholar 

  13. Takahashi M, Nishizawa T, Miyajima H, Gotanda Y, Iita T, Tsuda F, Okamoto H (2003) Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus. J Gen Virol 84:851–862

    Article  PubMed  CAS  Google Scholar 

  14. Toyoda K, Furusyo N, Takeoka H, Murata M, Sawayama Y, Hayashi J (2008) Epidemiological study of hepatitis E virus infection in the general population of Okinawa, Kyushu, Japan. J Gastroenterol Hepatol 23:1885–1890

    Article  PubMed  Google Scholar 

  15. Wibawa ID, Suryadarma IG, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H (2007) Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm swine in Bali, Indonesia. J Med Virol 79:1138–1146

  16. Wibawa ID, Muljono DH, Mulyanto, Suryadarma IG, Tsuda F, Takahashi M, Nishizawa T, Okamoto H (2004) Prevalence of antibodies to hepatitis E virus among apparently healthy humans and pigs in Bali, Indonesia: Identification of a pig infected with a genotype 4 hepatitis E virus. J Med Virol 73:38–44

    Article  PubMed  CAS  Google Scholar 

  17. Withers MR, Correa MT, Morrow M, Stebbins ME, Seriwatana J, Webster WD, Boak MB, Vaughn DW (2002) Antibody levels to hepatitis E virus in North Carolina swine workers, non-swine workers, swine, and murids. Am J Trop Med Hyg 66:384–388

    PubMed  Google Scholar 

  18. Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, Okamoto H (2003) Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in swine liver as food. J Gen Virol 84:2351–2357

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This study was supported by a grant-in-aid obtained through the Program of Founding Research Centers for Emerging and Re-emerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and JST/JICA, SATREPS. We wish to thank Prof. Ketut Suata of the Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Denpasar, and Dr. Sanjaya Putra I.G.N. and Dr. Arhana B.N.P. of Sanglah Hospital, Denpasar, Indonesia, for the collection of samples from the pediatric outpatient department of Sanglah Hospital.

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Correspondence to Hak Hotta.

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Utsumi, T., Hayashi, Y., Lusida, M.I. et al. Prevalence of hepatitis E virus among swine and humans in two different ethnic communities in Indonesia. Arch Virol 156, 689–693 (2011). https://doi.org/10.1007/s00705-010-0883-x

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  • DOI: https://doi.org/10.1007/s00705-010-0883-x

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