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Estimates of individuals exposed to human metapneumovirus in a community-based Taiwanese population in 1999

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Abstract

Human metapneumovirus (hMPV) causes both upper and lower respiratory tract infection worldwide. Because little is known about the estimated level of exposure to hMPV in Taiwan, data for 1999 are presented. One thousand one hundred twenty sera from otherwise healthy community-based subjects aged 1 month to 99 years were tested in an enzyme-linked immunosorbent assay; the proportion of seropositive individuals was 68.1%. Moreover, 53.2% of preschool children were seronegative, whereas 88.3% of school-aged individuals and 93.7% of adults had antibodies to hMPV. In summary, the present study provides an earlier evidence of a high rate of exposure to hMPV characterized the seroprevalence among Taiwanese individuals in 1999. In addition, our findings suggest that preschool children in particular would benefit from vaccination against hMPV.

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Acknowledgments

This study was supported by grants from the National Science Council in Taiwan, number NSC 93-2314-B-182A-207, 94-2320-B-182A-012, 95-2320-B-182A-002, and 96-2320-B-182A-001.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Chang Gung Memorial Hospital, 5, Fu-Shin Street, Kweishan, Taoyuan, 333, Taiwan

    Chung-Guei Huang, Kuo-Chien Tsao, Ya-Ling Huang & Shin-Ru Shih

  2. Department of Biotechnology and Laboratory Science, Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan

    Chung-Guei Huang, Kuo-Chien Tsao, Tzu-Hou Chen, Ya-Ling Huang & Shin-Ru Shih

  3. Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children’s Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Tzou-Yien Lin & Yhu-Chering Huang

  4. Department of Otolaryngology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Li-Ang Lee

  5. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Tzou-Yien Lin, Yhu-Chering Huang & Li-Ang Lee

Authors
  1. Chung-Guei Huang
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  2. Kuo-Chien Tsao
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  3. Tzou-Yien Lin
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  4. Yhu-Chering Huang
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  5. Li-Ang Lee
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  6. Tzu-Hou Chen
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  7. Ya-Ling Huang
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  8. Shin-Ru Shih
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Corresponding author

Correspondence to Kuo-Chien Tsao.

Additional information

C. G. Huang and K. C. Tsao contributed equally to this work.

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Huang, CG., Tsao, KC., Lin, TY. et al. Estimates of individuals exposed to human metapneumovirus in a community-based Taiwanese population in 1999. Arch Virol 155, 343–350 (2010). https://doi.org/10.1007/s00705-010-0596-1

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  • DOI: https://doi.org/10.1007/s00705-010-0596-1

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