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Experimental infection of calves with Newcastle disease virus induces systemic and mucosal antibody responses

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Abstract

Calves were infected intranasally and intratracheally with Newcastle disease virus (NDV), an avian paramyxovirus. Clinical signs, viral replication, and antibody production were evaluated. This study showed that NDV replicated in calves, as evidenced by development of NDV-specific humoral and mucosal antibody responses, but was attenuated in this unnatural host. These results suggest that NDV has the potential for development as a host-range-restricted, intranasal vaccine vector for cattle that lack preexisting immunity to NDV.

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Acknowledgment

We thank Dr. Chinta Lamichhane, Synbiotics Corporation and Dr. Subrat N. Rout for their excellent technical assistance, and Ireen Dryburgh-Barry for her guided critique of this manuscript.

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  1. Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, 20742, USA

    Madhuri Subbiah, Yongqi Yan, Daniel Rockemann & Siba K. Samal

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  1. Madhuri Subbiah
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  2. Yongqi Yan
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  3. Daniel Rockemann
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  4. Siba K. Samal
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Correspondence to Siba K. Samal.

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Subbiah, M., Yan, Y., Rockemann, D. et al. Experimental infection of calves with Newcastle disease virus induces systemic and mucosal antibody responses. Arch Virol 153, 1197–1200 (2008). https://doi.org/10.1007/s00705-008-0099-5

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  • DOI: https://doi.org/10.1007/s00705-008-0099-5

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