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Kinship, dispersal and hantavirus transmission in bank and common voles

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Abstract

Hantaviruses are among the main emerging infectious agents in Europe. Their mode of transmission in natura is still not well known. In particular, social features and behaviours could be crucial for understanding the persistence and the spread of hantaviruses in rodent populations. Here, we investigated the importance of kinclustering and dispersal in hantavirus transmission by combining a fine-scale spatiotemporal survey (4 km2) and a population genetics approach. Two specific host-hantavirus systems were identified and monitored: the bank vole Myodes, earlier Clethrionomys glareolus––Puumala virus and the common vole Microtus arvalis—Tula virus. Sex, age and landscape characteristics significantly influenced the spatial distribution of infections in voles. The absence of temporal stability in the spatial distributions of viruses suggested that dispersal is likely to play a role in virus propagation. Analysing vole kinship from microsatellite markers, we found that infected voles were more closely related to each other than non-infected ones. Winter kin-clustering, shared colonies within matrilineages or delayed dispersal could explain this pattern. These two last results hold, whatever the host-hantavirus system considered. This supports the roles of relatedness and dispersal as general features for hantavirus transmission.

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Acknowledgments

We thank Sylvain Piry, Florian Holon, Audrey Scala and Josef Bryja for assistance with the field work. We are very grateful to Valérie Deffontaine for lending microsatellites primers and the protocol for the bank vole. We also thank Johan Michaux for lending primers for Apodemus identification. This work was financed by a grant from the Ministry of Research and supported financially by the Institut National de la Recherche Agronomique, the region Franche-Comté and the DIREN Franche-Comté. Our work was also partially funded by EU grant GOCE-2003-010284 EDEN and is catalogued by the EDEN Steering Committee as EDEN0069 (http://www.eden-fp6project.net).

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Authors and Affiliations

  1. Centre de Biologie et de Gestion et des Populations (CBGP), INRA EFPA, Campus International de Baillarguet, CS 30016, 34988, Montferrier sur lez, France

    J. Deter, Y. Chaval, M. Galan, B. Gauffre, N. Charbonnel & J.-F. Cosson

  2. Institut des Sciences de l’Evolution, CNRS, CC064, Université Montpellier 2, 34095, Montpellier Cedex 05, France

    S. Morand

  3. Vantaa Research Unit, Finnish Forest Research Institute, PO Box 18, 01301, Vantaa, Finland

    H. Henttonen, J. Laakkonen & L. Voutilainen

  4. Department of Virology, Haartman Institute, University of Helsinki, PO Box 21, 00014, Helsinki, Finland

    J. Laakkonen

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  1. J. Deter
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  2. Y. Chaval
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  3. M. Galan
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  4. B. Gauffre
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  5. S. Morand
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  6. H. Henttonen
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  7. J. Laakkonen
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  9. N. Charbonnel
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  10. J.-F. Cosson
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Correspondence to J. Deter.

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N. Charbonnel and J.-F. Cosson have contributed equally.

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Deter, J., Chaval, Y., Galan, M. et al. Kinship, dispersal and hantavirus transmission in bank and common voles. Arch Virol 153, 435–444 (2008). https://doi.org/10.1007/s00705-007-0005-6

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