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Sendai virus infection up-regulates trypsin I and matrix metalloproteinase-9, triggering viral multiplication and matrix degradation in rat lungs and lung L2 cells

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Summary.

To elucidate the virus-host cell interaction, we analyzed quantitatively the expression of various cellular proteases and tumor necrosis factor-α (TNF-α) after Sendai virus infection in rat lungs and lung L2 cells. After infection, TNF-α mRNA levels increased rapidly to a peak on day one, and then trypsin I and matrix metalloproteinase (MMP)-9, but not MMP-2, were significantly up-regulated with a peak on day 2 in vivo. These up-regulations were confirmed in L2 cells. Up-regulation of proMMP-9 and its active convertase trypsin I seems to synergistically enhance virus multiplication and the destruction of lung matrix, resulting in the progression of pneumonia.

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Authors and Affiliations

  1. Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan

    H. Yamada, Q. T. Le, A. Kousaka, Y. Higashi, M. Tsukane & H. Kido

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  1. H. Yamada
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  2. Q. T. Le
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  3. A. Kousaka
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  4. Y. Higashi
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  5. M. Tsukane
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  6. H. Kido
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Yamada, H., Le, Q., Kousaka, A. et al. Sendai virus infection up-regulates trypsin I and matrix metalloproteinase-9, triggering viral multiplication and matrix degradation in rat lungs and lung L2 cells. Arch Virol 151, 2529–2537 (2006). https://doi.org/10.1007/s00705-006-0807-y

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  • DOI: https://doi.org/10.1007/s00705-006-0807-y

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