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Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

  • Psychiatry and Preclinical Psychiatric Studies - Short communication
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Abstract

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

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Acknowledgements

This study was funded by MCT/CT-Saúde—DECIT/SCTIE/MS, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant number 466802/2014-5), Secretaria Nacional de Políticas sobre Drogas (SENAD)/Ministério da Justiça (Grant Number 822647/2015). This study was also financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior—Brasil (CAPES)—Finance Code 001. This work was partially funded by National Institute on Drug Abuse (NIDA) Grant R01DA044859. The funding source had no involvement in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. The authors would like to thank all members of the Sistema de Saúde Mãe de Deus.

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Authors and Affiliations

  1. Developmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil

    Thiago Wendt Viola, Rafael Genovese, Lucca Tondo, Aline Zaparte & Rodrigo Grassi-Oliveira

  2. Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Jaqueline Bohrer Schuch

  3. Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Diego Luiz Rovaris

  4. ADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

    Diego Luiz Rovaris, Renata Basso Cupertino, Bruna Santos da Silva & Claiton Henrique Dotto Bau

  5. Department of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil

    Breno Sanvicente-Vieira

  6. Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Renata Basso Cupertino, Bruna Santos da Silva & Claiton Henrique Dotto Bau

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  1. Thiago Wendt Viola
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  2. Jaqueline Bohrer Schuch
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  3. Diego Luiz Rovaris
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  4. Rafael Genovese
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  5. Lucca Tondo
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  6. Breno Sanvicente-Vieira
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  7. Aline Zaparte
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  8. Renata Basso Cupertino
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  9. Bruna Santos da Silva
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  10. Claiton Henrique Dotto Bau
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  11. Rodrigo Grassi-Oliveira
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Correspondence to Rodrigo Grassi-Oliveira.

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Viola, T.W., Schuch, J.B., Rovaris, D.L. et al. Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder. J Neural Transm 126, 1707–1711 (2019). https://doi.org/10.1007/s00702-019-02086-w

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