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Differentiation of atypical Parkinson syndromes

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

In distinction to idiopathic Parkinson’s disease (PD), the diagnosis of atypical Parkinson syndromes comprises dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). We set out to write a state-of-the-art guideline as to which investigations and examinations help to differentiate PD vs. atypical Parkinson syndromes in clinical routine.

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Acknowledgements

G.U. Höglinger was funded by the Deutsche Forschungsgemeinschaft (DFG, HO2402/6-2).

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Authors and Affiliations

  1. Department of Neurology, Technische Universität München, Munich, Germany

    Günter U. Höglinger

  2. Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen Str. 17, 81677, Munich, Germany

    Günter U. Höglinger

  3. Department of Neurology, University of Ulm, Ulm, Germany

    Jan Kassubek

  4. Gertrudis-Kliniken, Biskirchen, Germany

    Ilona Csoti

  5. Office for Neurology, Berlin-Steglitz, Germany

    Reinhard Ehret

  6. Office for Neurology, Stuttgart, Germany

    Heinz Herbst

  7. Office for Neurology/Ev. Amalie Sieveking-Krankenhaus, Hamburg, Germany

    Ingmar Wellach

  8. Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

    Jürgen Winkler

  9. Parkinson Hospital Ortenau/University of Freiburg, Wolfach, Germany

    Wolfgang H. Jost

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  1. Günter U. Höglinger
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  2. Jan Kassubek
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  3. Ilona Csoti
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  4. Reinhard Ehret
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  6. Ingmar Wellach
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  7. Jürgen Winkler
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  8. Wolfgang H. Jost
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Correspondence to Günter U. Höglinger.

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Conflict of interest

The meeting of the authors to discuss this consensus statement was sponsored by AbbVie. G.U. Höglinger has served on the advisory boards for AbbVie, Alzprotect, Asceneuron, Bristol-Myers Squibb, Novartis, Roche, Sellas Life Sciences Group, UCB; has received honoraria for scientific presentations from Abbvie, Roche, Teva, UCB, has received research support from CurePSP, the German Academic Exchange Service (DAAD), German Parkinson’s Disease Foundation (DPG), German PSP Association (PSP Gesellschaft), German Research Foundation (DFG) and the German Ministry of Education and Research (BMBF), International Parkinson’s Fonds (IPF), the Sellas Life Sciences Group; has received institutional support from the German Center for Neurodegenerative Diseases (DZNE). J. Kassubek received consulting fees as an advisory board member and honoraria for scientific presentations as a speaker from UCB-Pharma, Teva Pharmaceuticals, Zambon, Medtronic, Desitin, AbbVie, Boehringer Ingelheim, GlaxoSmithKline, Merz Pharmaceuticals and Hoffmann-La Roche. I. Csoti received financial contributions from Novartis Pharma AG for the organization of CME workshops, as well as honoraria for taking part in an expert meeting and advisory boards. She has received honoraria for presentations from Abbvie, Zambon, Boehringer Ingelheim, TEVA Pharma, Lundbeck, Desitin, Orion Pharma and UCB. H. Herbst has received honoraria for scientific presentations and/or advisory board member from Abbvie, Böhringer, Bayer, UCB. R. Ehret is/was member of an advisory boards for Bial, Desitin, Global Kinetics, Gruenenthal, Mundipharma Germany GmbH & Co, Novartis, Roche, Sanofi, Teva, UCB-Pharma and speaker for Abbvie, Desitin, GE Healthcare, Medtronics, Mundipharma Germany, Novartis, Zambon. I. Wellach has received honoraria for scientific presentations and/or advisory board member AbbVie, Grünenthal, Desitin, UCB, Zambon. Jürgen Winkler has received honoraria for scientific presentations outside of the submitted work from Astrum IT GmbH, Teva GmbH, Ever Pharma GmbH, Desitin Arzneimittel GmbH, Abbvie GmbH & Co. KG, Biogen GmbH, GlaxoSmithKline GmbH & Co. KG. W.H. Jost has received honoraria for scientific presentations and/or advisory board member from Abbvie, Allergan, Bial, Desitin, Ipsen, Merz, UCB, Zambon.

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Höglinger, G.U., Kassubek, J., Csoti, I. et al. Differentiation of atypical Parkinson syndromes. J Neural Transm 124, 997–1004 (2017). https://doi.org/10.1007/s00702-017-1700-4

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