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The contribution of white matter lesions to Parkinson’s disease motor and gait symptoms: a critical review of the literature

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

White matter lesions (WML) associated with cerebrovascular disease (CVD) may be observed on magnetic resonance imaging in Parkinson’s disease (PD) patients. WML are an important factor contributing to postural, gait, and cognitive impairment in the elderly without PD and worsening the course of Alzheimer’s disease (AD). Numerous articles are available on this topic. Whether WML modify and negatively influence the clinical symptoms, and course of PD is a subject of debate. The aim of this review is to examine the available literature on the contribution of WML to PD motor symptoms in relation to clinical characteristics and methods of assessing WML on MRI. After reviewing the database, we identified 19 studies reporting the relationship between WML and PD; ten studies focusing on the impact of WML on the cognitive status in PD were excluded. We analysed altogether nine studies reporting the relationship between WML and motor signs of PD. The review found association between WML severity and freezing of gait, less significant to responsiveness to dopaminergic treatment and postural instability; no negative impact on tremor and falls was observed. The impact of WML on bradykinesia and rigidity was inconsistent. Comorbid WML is associated with worsening axial motor performance, probably independently from the degree of nigrostriatal dopaminergic denervation in PD. Reducing the vascular risk factors that cause WML may be helpful in preventing the development of axial symptoms and ultimately in improving the quality of life of patients with PD. Given the lack of systematic studies, additional research in this field is needed.

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References

  • Acharya HJ, Bouchard TP, Emery DJ, Camicioli RM (2007) Axial signs and magnetic resonance imaging correlates in Parkinson’s disease. Can J Neurol Sci 34(1):56–61

    Article  PubMed  Google Scholar 

  • Antonini A, Vontobel P, Psylla M et al (1995) Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson’s disease. Arch Neurol 52(12):1183–1190

    Article  CAS  PubMed  Google Scholar 

  • Antonini A, Vitale C, Barone P et al (2012) The relationship between cerebral vascular disease and parkinsonism: the VADO study. Parkinsonism Relat Disord 18(6):775–780

    Article  CAS  PubMed  Google Scholar 

  • Auriel E et al (2011) Clinical, radiological and pathological correlates of leukoaraiosis. Acta Neurol Scand 123:41–47

    Article  CAS  PubMed  Google Scholar 

  • Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke 17(6):1084–1089

    Article  CAS  PubMed  Google Scholar 

  • Baezner H et al (2008) Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70:935–942

    Article  CAS  PubMed  Google Scholar 

  • Balash Y, Korczyn AD (2007) Vascular parkinsonism. Handb Clin Neurol 84:417–425

    Article  PubMed  Google Scholar 

  • Becker C, Jick SS, Meier CR (2010) Risk of stroke in patients with idiopathic Parkinson disease. Parkinsonism Relat Disord 16(1):31–35

    Article  PubMed  Google Scholar 

  • Beyer MK, Aarsland D, Greve OJ, Larsen JP (2006) Visual rating of white matter hyperintensities in Parkinson’s disease. Mov Disord 21(2):223–229

    Article  PubMed  Google Scholar 

  • Bohnen NI, Müller ML, Koeppe RA et al (2009) History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology 73(20):1670–1676

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bohnen NI, Müller ML, Zarzhevsky N et al (2011) Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease. Brain 134(8):2358–2365

    Article  PubMed Central  PubMed  Google Scholar 

  • Boland EJ, Nair PK, Lemon DD, Olson JS, Hellums JD (1987) An in vitro capillary system for studies on microcirculatory O2 transport. J Appl Physiol 62(2):791–797

    CAS  PubMed  Google Scholar 

  • Bonilha L, de Vries PM, Hurd MW et al (2009) Disrupted thalamic prefrontal pathways in patients with idiopathic dystonia. Parkinsonism Relat Disord 15(1):64–67

    Article  PubMed  Google Scholar 

  • Braak H, Del TK et al (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24(24):197–211

    Article  PubMed  Google Scholar 

  • Braak H, Bohl JR, Muller CM, Rub U, De Vos RA, Del Tredici K (2006) Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson’s disease reconsidered. Mov Disord 21:2042–2051

    Article  PubMed  Google Scholar 

  • D’Agostino RB Sr, Vasan RS, Pencina MJ et al (2008) General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117(6):743–753

    Article  PubMed  Google Scholar 

  • Dalaker TO, Larsen JP, Dwyer MG et al (2009) White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson’s disease. Neuroimage 47(4):2083–2089

    Article  PubMed  Google Scholar 

  • de Boer R, Vrooman HA, van der Lijn F et al (2009) White matter lesion extension to automatic brain tissue segmentation on MRI. Neuroimage 45(4):1151–1161

    Article  PubMed  Google Scholar 

  • de Groot JC, de Leeuw FE, Oudkerk M et al (2000) Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol 47(2):145–151

    Article  PubMed  Google Scholar 

  • de Laat KF, Tuladhar AM, van Norden AG, Norris DG, Zwiers MP, de Leeuw FE (2011) Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 134(Pt 1):73–83

    Article  PubMed  Google Scholar 

  • de Reuck J, Sieben G, de Coster W, vander Ecken H (1980) Parkinsonism in patients with cerebral infarcts. Clin Neurol Neurosurg 82:177–185

    Article  PubMed  Google Scholar 

  • Delwaide PJ, Gonce M (1993) Pathophysiology of Parkinson’s signs. In: Jankovic J, Tolosa E (eds) Parkinson’s disease and movement disorders, 2nd edn. Williams and Wilkins, Baltimore, pp 77–92

    Google Scholar 

  • Derejko M, Slawek J, Wieczorek D, Dubaniewicz M, Lass P (2006) The influence of vascular risk factors and white matter hyperintensities on the degree of motor impairment in Parkinson’s disease. Neurol Neurochir Pol 40(4):276–283

    PubMed  Google Scholar 

  • Diller TE, Pattantyus IA, Britts WC (1984) Augmentation facilitation of oxygen transfer in flowing hemoglobin solutions. Adv Exp Med Biol 180:545–554

    Article  CAS  PubMed  Google Scholar 

  • Ebersbach G, Sojer M, Valldeoriola F et al (1999) Comparative analysis of gait in Parkinson’s disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. Brain 122(Pt 7):1349–1355

    Article  PubMed  Google Scholar 

  • Eidelberg D, Moeller JR, Dhawan V et al (1990) The metabolic anatomy of Parkinson’s disease: complementary [18F] fluorodeoxyglucose and [18F] fluorodopa positron emission tomographic studies. Mov Disord 5(3):203–213

    Article  CAS  PubMed  Google Scholar 

  • Fahn S, Elton RL, Members of the UPDRS Development Committee (1987) Unified Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease, vol 2. Macmillan Health Care Information, Florham Park

    Google Scholar 

  • Fenelon G, Houeto JL (1997) Unilateral parkinsonism following a large infarct in the territory of the lenticulostriate arteries. Mov Disord 12:1086–1090

    Article  CAS  PubMed  Google Scholar 

  • Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MRI signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 149(2):351–356

    Article  CAS  PubMed  Google Scholar 

  • Fenelon G, Houeto JL (1998) Les syndromes parkinsoniens vasculaires: un concept controversé. Rev Neurol 154(4):291–302

    CAS  PubMed  Google Scholar 

  • Fling BW, Cohen RG, Mancini M, Nutt JG, Fair DA, Horak FB (2013) Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait. Brain 136(Pt 8):2405–2418

    Article  PubMed Central  PubMed  Google Scholar 

  • Gallardo MJ, Cabello JP, Pastor C et al (2014) Patients with advanced Parkinson’s disease with and without freezing of gait: a comparative analysis of vascular lesions using brain MRI. Neurologia 29(4):218–223

    Article  CAS  PubMed  Google Scholar 

  • George AE, de Leon MJ, Kalnin A, Rosner L, Goodgold A, Chase N (1986) Leukoencephalopathy in normal and pathologic aging, II: MRI of brain lucencies. AJNR Am J Neuroradiol 7:567–570

    CAS  PubMed  Google Scholar 

  • Ghebremedhin E, Rosenberger A, Rüb U et al (2010) Inverse relationship between cerebrovascular lesions and severity of Lewy body pathology in patients with Lewy body disease. J Neuropathol Exp Neurol 69(5):442–448

    Article  PubMed  Google Scholar 

  • González-Redondo R, Toledo J, Clavero P et al (2012) The impact of silent vascular brain burden in cognitive impairment in Parkinson’s disease. Eur J Neurol 19(8):1100–1107

    Article  PubMed  Google Scholar 

  • Gorell JM, Johnson CC, Rybicki BA (1994) Parkinson’s disease and its comorbid disorders: an analysis of Michigan mortality data, 1970 to 1990. Neurology. 44(10):1865–1868

    Article  CAS  PubMed  Google Scholar 

  • Gouw AA, van der Flier WM, van Straaten EC et al (2008) Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression. Cerebrovasc Dis 25(3):247–253

    Article  CAS  PubMed  Google Scholar 

  • Gouw AA, Seewann A, van der Flier WM et al (2011) Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry 82(2):126–135. doi:10.1136/jnnp.2009.204685

    Article  PubMed  Google Scholar 

  • Guan J, Pavlovic D, Dalkie N et al (2013) Vascular degeneration in Parkinson’s disease. Brain Pathol 23(2):154–164

    Article  CAS  PubMed  Google Scholar 

  • Herman T, Rosenberg-Katz K, Jacob Y et al (2013) White matter hyperintensities in Parkinson’s disease: do they explain the disparity between the postural instability gait difficulty and tremor dominant subtypes? PLoS One 8(1):e55193. doi:10.1371/journal.pone.0055193

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 57(10 Suppl 3):S11–S26

    Google Scholar 

  • Horak FB (2006) Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Age Ageing 35(Suppl 2):ii7–ii11

    PubMed  Google Scholar 

  • Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathologic study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Intaglietta M, Johnson PC, Winslow RM (1996) Microvascular and tissue oxygen distribution. Cardiovasc Res 32(4):632–643

    Article  CAS  PubMed  Google Scholar 

  • Inzelberg R, Bornstein NM, Reider I, Korczyn AD (1994) Basal ganglia lacunes and parkinsonism. Neuroepidemiology 13(3):108–112

    Article  CAS  PubMed  Google Scholar 

  • Jahn K, Deutschländer A, Stephan T et al (2008) Imaging human supraspinal locomotor centers in brainstem and cerebellum. Neuroimage 39(2):786–792

    Article  PubMed  Google Scholar 

  • Jankovic J, McDermott M, Carter J et al (1990) Variable expression of Parkinson’s disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology 40(10):1529–1534

    Article  CAS  PubMed  Google Scholar 

  • Jellinger KA (1996) The neuropathologic diagnosis of secondary parkinsonian syndromes. Adv Neurol 69:293–303

    CAS  PubMed  Google Scholar 

  • Jellinger KA (2002) Vascular parkinsonism—neuropathological findings. Acta Neurol Scand 105:414–415

    Article  CAS  PubMed  Google Scholar 

  • Jellinger KA (2003) Prevalence of cerebrovascular lesions in Parkinson’s disease. A postmortem study. Acta Neuropathol 105(5):415–419

    PubMed  Google Scholar 

  • Kandiah N, Mak E, Ng A et al (2013) Cerebral white matter hyperintensity in Parkinson’s disease: a major risk factor for mild cognitive impairment. Parkinsonism Relat Disord 19(7):680–683

    Article  PubMed  Google Scholar 

  • Kapeller P, Barber R, Vermeulen RJ et al (2003) Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements. Stroke 34(2):441–445

    Article  CAS  PubMed  Google Scholar 

  • Kelly VE, Johnson CO, Leverenz JB et al (2015) Association of cognitive domains with postural instability/gait disturbance in Parkinson’s disease. Parkinsonism Relat Disord 21:692–697

    Article  CAS  PubMed  Google Scholar 

  • Kim JS, Lee PH, Lee KS et al (2006) Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism. Mov Disord 21(11):1990–1994

    Article  PubMed  Google Scholar 

  • Korczyn AD (2015) Vascular parkinsonism—characteristics, pathogenesis and treatment. Nat Rev Neurol. 11(6):319–326

    Article  PubMed  Google Scholar 

  • Kotagal V, Albin RL, Muller ML, Koeppe RA, Frey KA, Bohnen NI (2014) Modifiable cardiovascular risk factors and axial motor impairments in Parkinson disease. Neurology 82(17):1514–1520

    Article  PubMed Central  PubMed  Google Scholar 

  • Kuo HK, Lipsitz LA (2004) Cerebral white matter changes and geriatric syndromes: is there a link? J Gerontol A Biol Sci Med Sci 59(8):818–826

    Article  PubMed  Google Scholar 

  • Lee SJ, Kim JS, Lee KS et al (2009) The severity of leukoaraiosis correlates with the clinical phenotype of Parkinson’s disease. Arch Gerontol Geriatr 49(2):255–259

    Article  PubMed  Google Scholar 

  • Lee SJ, Kim JS, Yoo JY et al (2010) Influence of white matter hyperintensities on the cognition of patients with Parkinson disease. Alzheimer Dis Assoc Disord 24(3):227–233

    PubMed  Google Scholar 

  • Lee MJ, Kim SL, Kim JI et al (2015) [18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis. Parkinsonism Relat Disord 21:704–708

    Article  CAS  PubMed  Google Scholar 

  • Levine RL, Jones JC, Bee N (1992) Stroke and Parkinson’s disease. Stroke 23(6):839–842

    Article  CAS  PubMed  Google Scholar 

  • Mastaglia FL, Johnsen RD, Kakulas BA (2002) Prevalence of stroke in Parkinson’s disease: a postmortem study. Mov Disord 17(4):772–774

    Article  PubMed  Google Scholar 

  • Mesulam MM (1990) Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol 28(5):597–613

    Article  CAS  PubMed  Google Scholar 

  • Meyer JS, Huang J, Chowdhury MH (2007) MRI confirms mild cognitive impairments prodromal for Alzheimer’s, vascular and Parkinson-Lewy body dementias. J Neurol Sci 257(1–2):97–104

    Article  PubMed  Google Scholar 

  • Murray ME, Senjem ML, Petersen RC et al (2010) Functional impact of white matter hyperintensities in cognitively normal elderly subjects. Arch Neurol 67(11):1379–1385

    PubMed Central  PubMed  Google Scholar 

  • Nachev P, Kennard C, Husain M (2008) Functional role of the supplementary and pre-supplementary motor areas. Nat Rev Neurosci 9(11):856–869

    Article  CAS  PubMed  Google Scholar 

  • Nataraj A, Rajput AH (2005) Parkinson’s disease, stroke, and related epidemiology. Mov Disord 20(11):1476–1480

    Article  PubMed  Google Scholar 

  • Ng A, Chew I, Tay KY, Au WL, Tan L, Kandiah N (2012) White matter disease adversely influences cognition in idiopathic Parkinson’s disease. Alzheimer’s Dement 8(4):171–172

    Article  Google Scholar 

  • Nutt JG (2013) Higher-level gait disorders: an open frontier. Mov Disord 28:1560–1565

    Article  PubMed  Google Scholar 

  • Nutt JG, Bloem BR, Giladi N, Hallett M, Horak FB, Nieuwboer A (2011) Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 10(8):734–744

    Article  PubMed  Google Scholar 

  • Ohta K, Obara K (2006) Hemiparkinsonism with a discrete lacunar infarction in the contralateral substantia nigra. Mov Disord 21:124–125

    Article  PubMed  Google Scholar 

  • Piccini P, Pavese N, Canapicchi R et al (1995) White matter hyperintensities in Parkinson’s disease: clinical correlations. Arch Neurol 52(2):191–194

    Article  CAS  PubMed  Google Scholar 

  • Pirker W (2003) Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Mov Disord 18(Suppl 7):S43–S51

    Article  PubMed  Google Scholar 

  • Ragno M, Berbellini A, Cacchiò G et al (2013) Parkinsonism is a late, not rare, feature of CADASIL: a study on Italian patients carrying the R1006C mutation. Stroke 44(4):1147–1149

    Article  PubMed  Google Scholar 

  • Rampello L, Alvano A, Battaglia G, Raffaele R, Vecchio I, Malaguarnera M (2005) Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism. J Neurol 252:1045–1049

    Article  CAS  PubMed  Google Scholar 

  • Rektor I, Rektorová I, Kubová D (2006) Vascular parkinsonism—an update. J Neurol Sci 248(1–2):185–191

    Article  PubMed  Google Scholar 

  • Rektor I, Goldemund D, Sheardová K, Rektorová I, Michálková Z, Dufek M (2009) Vascular pathology in patients with idiopathic Parkinson’s disease. Parkinsonism Relat Disord. 15(1):24–29

    Article  PubMed  Google Scholar 

  • Rektor I, Goldemund D, Bednařík P et al (2012) Impairment of brain vessels may contribute to mortality in patients with Parkinson’s disease. Mov Disord 27(9):1169–1172

    Article  PubMed  Google Scholar 

  • Rektorova I, Srovnalova H, Kubikova R, Prasek J (2008) Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson’s disease. Mov Disord 23(11):1580–1587

    Article  PubMed  Google Scholar 

  • Rosenberg GA, Bjerke M, Wallin A (2014) Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment. Stroke 45:1531–1538

    Article  PubMed Central  PubMed  Google Scholar 

  • Santangelo G, Vitale C, Trojano L et al (2010) Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions. Mov Disord 25(1):50–56

    Article  PubMed  Google Scholar 

  • Scheltens P, Barkhof F, Leys D et al (1993) A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 114(1):7–12

    Article  CAS  PubMed  Google Scholar 

  • Sibon I, Fenelon G, Quinn NP, Tison F (2004) Vascular parkinsonism. J Neurol 251(5):513–524

    Article  PubMed  Google Scholar 

  • Sławek J, Wieczorek D, Derejko M et al (2008) The influence of vascular risk factors and white matter hyperintensities on the degree of cognitive impairment in Parkinson’s disease. Neurol Neurochir Pol 42(6):505–512

    PubMed  Google Scholar 

  • Sławek J, Roszmann A, Robowski P et al (2013) The impact of MRI white matter hyperintensities on dementia in Parkinson’s disease in relation to the homocysteine level and other vascular risk factors. Neurodegener Dis 12(1):1–12

    Article  PubMed  CAS  Google Scholar 

  • Smart SD, Firbank MJ, O’Brien JT (2011) Validation of automated white matter hyperintensity segmentation. J Aging Res 2011. Art ID 391783

  • Snijders AH, Leunissen I, Bakker M et al (2011) Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait. Brain 134(Pt 1):59–72

    Article  PubMed  Google Scholar 

  • Sohn YH, Kim JS (1998) The influence of white matter hyperintensities on the clinical features of Parkinson’s disease. Yonsei Med J 39(1):50–55

    Article  CAS  PubMed  Google Scholar 

  • Song IU, Kim YD, Cho HJ, Chung SW (2013) The effects of silent cerebral ischemic lesions on the prognosis of idiopathic Parkinson’s disease. Parkinsonism Relat Disord 19(8):761–763

    Article  PubMed  Google Scholar 

  • Struck LK, Rodnitzky RL, Dobson JK (1990) Stroke and its modification in Parkinson’s disease. Stroke 21(10):1395–1399

    Article  CAS  PubMed  Google Scholar 

  • van Straaten EC, Fazekas F, Rostrup E et al (2006) Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke 37(3):836–840

    Article  PubMed  Google Scholar 

  • Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM (2002) Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 33:21–25

    Article  PubMed  Google Scholar 

  • Veselý B, Rektor I The contribution of white matter lesions (WML) to Parkinson’s disease cognitive impairment symptoms: a critical review of the literature. Parkinsonism Relat Disord (in press)

  • Vingerhoets FJ, Schulzer M, Calne DB, Snow BJ (1997) Which clinical sign of Parkinson’s disease best reflects the nigrostriatal lesion? Ann Neurol. 41(1):58–64

    Article  CAS  PubMed  Google Scholar 

  • Vizcarra JA, Lang AE, Espay AJ et al (2015) Vascular Parkinsonism: deconstructing a syndrome. Mov Disord 30(7):886–894

    Article  CAS  PubMed  Google Scholar 

  • Wahlund LO, Barkhof F, Fazekas F et al (2001) A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 32(6):1318–1322

    Article  CAS  PubMed  Google Scholar 

  • Watts RL, Mandir AS (1992) The role of motor cortex in the pathophysiology of voluntary movement deficits associated with parkinsonism. Neurol Clin 10(2):451–469

    CAS  PubMed  Google Scholar 

  • Whitwell JL, Avula R, Master A et al (2011) Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study. Parkinsonism Relat Disord. 17(8):599–605

    Article  PubMed Central  PubMed  Google Scholar 

  • Winikates J, Jankovic J (1999) Clinical correlates of vascular parkinsonism. Arch Neurol 56(1):98–102

    Article  CAS  PubMed  Google Scholar 

  • Wolf DS, Gearing M, Snowdon DA, Mori H, Markesbery WR, Mirra SS (1999) Progression of regional neuropathology in Alzheimer disease and normal elderly: findings from the Nun study. Alzheimer Dis Assoc Disord 13:226–231

    Article  CAS  PubMed  Google Scholar 

  • Wolfe N, Linn R, Babikian VL, Knoefel JE, Albert ML (1990) Frontal systems impairment following multiple lacunar infarcts. Arch Neurol 47(2):129–132

    Article  CAS  PubMed  Google Scholar 

  • Wong TY, Klein R, Sharrett AR et al (2002) Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 288(1):67–74

    Article  PubMed  Google Scholar 

  • Zheng JJ, Delbaere K, Close JC, Sachdev PS, Lord SR (2011) Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review. Stroke 42(7):2086–2090

    Article  PubMed  Google Scholar 

  • Zijlmans JC, Katzenschlager R, Daniel SE, Lees AJ (2004) The l-dopa response in vascular parkinsonism. J Neurol Neurosurg Psychiatry 75(4):545–547

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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  1. Department of Neurology, Faculty Hospital Nitra, Špitálska 6, 949 01, Nitra, Slovak Republic

    Branislav Veselý

  2. Parkinson’s Disease and Movement Disorders Unit, IRCCS Fondazione Ospedale San Camillo, Venice, Italy

    Angelo Antonini

  3. First Department of Neurology, Center of Neuroscience and Movement Disorders Centre, Central European Institute of Technology (CEITEC), St. Anne’s University Hospital, School of Medicine, Masaryk University, Pekařská 664/53, 656 91, Brno, Czech Republic

    Ivan Rektor

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  1. Branislav Veselý
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  2. Angelo Antonini
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Branislav Veselý M.D. reports no disclosures. Prof. Angelo Antonini M.D., Ph.D. reports no disclosures. Prof. Ivan Rektor M.D., CSc FCMA, FANA reports no disclosures.

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Veselý, B., Antonini, A. & Rektor, I. The contribution of white matter lesions to Parkinson’s disease motor and gait symptoms: a critical review of the literature. J Neural Transm 123, 241–250 (2016). https://doi.org/10.1007/s00702-015-1470-9

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