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No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson’s disease in a Chinese Han population

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Recently, a series of studies found that the single-nucleotide polymorphisms (SNPs) rs6812193 in the family with sequence similarity 47, member E (FAM47E), rs6825004 in the scavenger receptor class B member 2 (SCARB2) and rs4889603 in the Syntaxin1B (STX1B) genes increase the risk for Parkinson’s disease (PD). However, the results of subsequent independent studies were inconsistent. To explore the associations between the three SNPs and PD in the Chinese population, a large cohort was analyzed in a case–control study. A total of 1994 subjects, including 1179 PD and 815 healthy controls (HCs), were investigated. All subjects were genotyped for rs6812193, rs6825004 and rs4889603 using the Sequenom iPLEX Assay. There was no significant difference in additive genetic model of rs6812193, rs6825004 and rs4889603 between PD and controls, even after being stratified by sex and age. In addition, no significant differences were found between other subgroups of PD patients with regard to clinical presentation. Our findings suggested that FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 do not confer a significant risk for PD in Chinese population.

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Acknowledgments

The authors thank the patients for their participation in the study.

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    1. Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People’s Republic of China

      YongPing Chen, XiaoQin Yuan, Bei Cao, QianQian Wei, RuWei Ou, Jing Yang, XuePing Chen, Bi Zhao, Wei Song, Ying Wu & HuiFang Shang

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    1. YongPing Chen
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    Correspondence to HuiFang Shang.

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    Y. Chen and X. Yuan contributed to the study equally.

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    Chen, Y., Yuan, X., Cao, B. et al. No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson’s disease in a Chinese Han population. J Neural Transm 122, 1547–1552 (2015). https://doi.org/10.1007/s00702-015-1430-4

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