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Pedunculopontine stimulation from primate to patient

  • Movement Disorders - Original Article
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Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson’s disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

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Acknowledgments

The authors are supported by grants from the UK Medical Research Council, The Norman Collisson Foundation, The Charles Wolfson Charitable Trust and Oxford Comprehensive Biomedical Research Centre.

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Authors and Affiliations

  1. Oxford Functional Neurosurgery, Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Erlick A. C. Pereira, Ned Jenkinson, John F. Stein, Alexander L. Green & Tipu Z. Aziz

  2. Nuffield Department of Surgery, University of Oxford, Oxford, UK

    Erlick A. C. Pereira, Ned Jenkinson, John F. Stein, Alexander L. Green & Tipu Z. Aziz

  3. Imperial College Neuromodulation Group, Charing Cross Hospital and Division of Neuroscience and Mental Health, Imperial College London, London, UK

    Dipankar Nandi

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  1. Erlick A. C. Pereira
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Correspondence to Erlick A. C. Pereira.

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Pereira, E.A.C., Nandi, D., Jenkinson, N. et al. Pedunculopontine stimulation from primate to patient. J Neural Transm 118, 1453–1460 (2011). https://doi.org/10.1007/s00702-011-0631-8

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