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Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs

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Summary

Migraine is regarded as a polygenic disease and serotonergic pathways appear to play a major role in its pathogenesis. In the present study, the role of the 5-HT1A and 5-HT1B receptors in migraine was evaluated. The human 5-HT1A receptor gene transcription is modulated by a functional C-1019G promoter polymorphism. The 5-HT1B receptor is the main effector of vasoconstriction in meningeal and cerebral arteries and its functional G861C promoter polymorphism was investigated. We report a positive association of the GG genotype of the 5-HT1A promoter polymorphism with avoidance of physical activity during a migraine attack in comparison to the CC genotype (p = 0.008). Moreover, a positive association of the CC genotype of the G861C polymorphism of the 5-HT1B receptor with the reported intensity of the headache attack on the visual analogue scale was observed (CC 8.3 ± 1.5 vs. GG 6.9 ± 1.8; p < 0.05). An association of either polymorphism with migraine with or without aura could not be found.

For the first time, our results indicate a role of allelic variation of the 5-HT1A receptor in motion related discomfort in migraineurs and a role of the 5-HT1B receptor polymorphism in headache intensity.

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Authors and Affiliations

  1. Department of Neurology, University of Würzburg, Würzburg, Germany

    M. Marziniak & C. Sommer

  2. Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany

    R. Mössner, C. Kienzler, P. Riederer & K.-P. Lesch

  3. Department of Neurology, Saarland University, Homburg, Germany

    M. Marziniak

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  1. M. Marziniak
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  2. R. Mössner
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  3. C. Kienzler
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  5. K.-P. Lesch
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Marziniak, M., Mössner, R., Kienzler, C. et al. Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs. J Neural Transm 114, 1227–1232 (2007). https://doi.org/10.1007/s00702-007-0713-9

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