Skip to main content
SpringerLink
Log in

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Summary

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • S Anttila K Huuhka M Huuhka R Rontu KM Mattila E Leinonen T Lehtimäki (2007) ArticleTitleInteraction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression J Neural Transm 114 461–468 10.1007/s00702-006-0583-6 Occurrence Handle10.1007/s00702-006-0583-6 Occurrence Handle1:CAS:528:DC%2BD2sXjtlygtrc%3D Occurrence Handle17066254

    Article  CAS  PubMed  Google Scholar 

  • JA Bueller M Aftab S Sen D Gomez-Hassan M Burmeister JK Zubieta (2006) ArticleTitleBDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects Biol Psychiatry 59 812–815 10.1016/j.biopsych.2005.09.022 Occurrence Handle10.1016/j.biopsych.2005.09.022 Occurrence Handle1:CAS:528:DC%2BD28XjsFOnt78%3D Occurrence Handle16442082

    Article  CAS  PubMed  Google Scholar 

  • A Caspi K Sugden TE Moffitt A Taylor IW Craig H Harrington J McClay J Mill J Martin A Braithwaite R Poulton (2003) ArticleTitleInfluence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 386–389 10.1126/science.1083968 Occurrence Handle10.1126/science.1083968 Occurrence Handle1:CAS:528:DC%2BD3sXls1ygsrw%3D Occurrence Handle12869766

    Article  CAS  PubMed  Google Scholar 

  • E Castren (2004) ArticleTitleNeurotrophic effects of antidepressant drugs Curr Opin Pharmacol 4 58–64 10.1016/j.coph.2003.10.004 Occurrence Handle10.1016/j.coph.2003.10.004 Occurrence Handle1:CAS:528:DC%2BD2cXpsVGjtQ%3D%3D Occurrence Handle15018840

    Article  CAS  PubMed  Google Scholar 

  • RS Duman LM Monteggia (2006) ArticleTitleA neurotrophic model for stress-related mood disorders Biol Psychiatry 59 1116–1127 10.1016/j.biopsych.2006.02.013 Occurrence Handle10.1016/j.biopsych.2006.02.013 Occurrence Handle1:CAS:528:DC%2BD28XmtVOisbc%3D Occurrence Handle16631126

    Article  CAS  PubMed  Google Scholar 

  • DL Dunner AJ Rush JM Russell M Burke S Woodard P Wingard J Allen (2006) ArticleTitleProspective, long-term, multicenter study of the naturalistic outcomes of patients with treatment-resistant depression J Clin Psychiatry 67 688–695 Occurrence Handle10.4088/JCP.v67n0501 Occurrence Handle16841617

    Article  PubMed  Google Scholar 

  • MF Egan M Kojima JH Callicott TE Goldberg BS Kolachana A Bertolino E Zaitsev B Gold D Goldman M Dean B Lu DR Weinberger (2003) ArticleTitleThe BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 257–269 10.1016/S0092-8674(03)00035-7 Occurrence Handle10.1016/S0092-8674(03)00035-7 Occurrence Handle1:CAS:528:DC%2BD3sXpvVemug%3D%3D Occurrence Handle12553913

    Article  CAS  PubMed  Google Scholar 

  • A Fagiolini DJ Kupfer (2003) ArticleTitleIs treatment-resistant depression a unique subtype of depression? Biol Psychiatry 53 640–648 10.1016/S0006-3223(02)01670-0 Occurrence Handle10.1016/S0006-3223(02)01670-0 Occurrence Handle12706950

    Article  PubMed  Google Scholar 

  • M Fava (2003) ArticleTitleDiagnosis and definition of treatment-resistant depression Biol Psychiatry 53 649–659 10.1016/S0006-3223(03)00231-2 Occurrence Handle10.1016/S0006-3223(03)00231-2 Occurrence Handle12706951

    Article  PubMed  Google Scholar 

  • CJ Hong TJ Chen YW Yu SJ Tsai (2006) ArticleTitleResponse to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder Pharmacogenomics J 6 27–33 10.1038/sj.tpj.6500340 Occurrence Handle10.1038/sj.tpj.6500340 Occurrence Handle1:CAS:528:DC%2BD28XjtVyltQ%3D%3D Occurrence Handle16302021

    Article  CAS  PubMed  Google Scholar 

  • M Huuhka S Anttila E Leinonen K Huuhka R Rontu KM Mattila H Huhtala T Lehtimäki (2005) ArticleTitleThe apolipoprotein E polymorphism is not associated with response to electroconvulsive therapy in major depressive disorder J ECT 21 7–11 10.1097/01.yct.0000153210.25362.ea Occurrence Handle10.1097/01.yct.0000153210.25362.ea Occurrence Handle1:CAS:528:DC%2BD2MXht1Ghtr%2FO Occurrence Handle15791170

    Article  CAS  PubMed  Google Scholar 

  • Huuhka K, Anttila S, Huuhka M, Leinonen E, Rontu R, Mattila KM, Lehtimäki T (2006) Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with the response to electroconvulsive therapy in major depressive disorder. Eur Arch Psychiatry Clin Neurosci (in press)

  • JP Hwang SJ Tsai CJ Hong CH Yang JF Lirng YM Yang (2005) ArticleTitleThe Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression Neurobiol Aging 827 1834–1837

    Google Scholar 

  • X Jiang K Xu J Hoberman F Tian AJ Marko JF Waheed CR Harris AM Marini MA Enoch RH Lipsky (2005) ArticleTitleBDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects Neuropsychopharmacology 30 1353–1361 Occurrence Handle1:CAS:528:DC%2BD2MXlt1KmsL8%3D Occurrence Handle15770238

    CAS  PubMed  Google Scholar 

  • S Lemonde G Turecki D Bakish L Du PD Hrdina CD Bown A Sequeira N Kushwaha SJ Morris A Basak XM Ou PR Albert (2003) ArticleTitleImpaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide J Neurosci 23 8788–8799 Occurrence Handle1:CAS:528:DC%2BD3sXnvVWlsr8%3D Occurrence Handle14507979

    CAS  PubMed  Google Scholar 

  • DF Levinson (2006) ArticleTitleThe genetics of depression: a review Biol Psychiatry 60 84–92 Occurrence Handle10.1016/j.biopsych.2005.08.024 Occurrence Handle1:CAS:528:DC%2BD28Xmsl2ju74%3D Occurrence Handle16300747

    Article  CAS  PubMed  Google Scholar 

  • KJ Livak (1999) ArticleTitleAllelic discrimination using fluorogenic probes and the 5′ nuclease assay Genet Anal 14 143–149 Occurrence Handle1:CAS:528:DyaK1MXhvVylsbo%3D Occurrence Handle10084106

    CAS  PubMed  Google Scholar 

  • P Oswald J Del-Favero I Massat D Souery S Claes C Van Broeckhoven J Mendlewicz (2005) ArticleTitleNo implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies Eur Neuropsychopharmacol 15 491–495 10.1016/j.euroneuro.2005.01.001 Occurrence Handle10.1016/j.euroneuro.2005.01.001 Occurrence Handle1:CAS:528:DC%2BD2MXpslyhtLw%3D Occurrence Handle16139165

    Article  CAS  PubMed  Google Scholar 

  • RV Parsey MA Oquendo RT Ogden DM Olvet N Simpson YY Huang RL Van Heertum V Arango JJ Mann (2006) ArticleTitleAltered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study Biol Psychiatry 59 106–113 10.1016/j.biopsych.2005.06.016 Occurrence Handle10.1016/j.biopsych.2005.06.016 Occurrence Handle1:CAS:528:DC%2BD28XotVGksg%3D%3D Occurrence Handle16154547

    Article  CAS  PubMed  Google Scholar 

  • T Saarelainen P Hendolin G Lucas E Koponen M Sairanen E MacDonald K Agerman A Haapasalo H Nawa R Aloyz P Ernfors E Castren (2003) ArticleTitleActivation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects J Neurosci 23 349–357 Occurrence Handle1:CAS:528:DC%2BD3sXktlagug%3D%3D Occurrence Handle12514234

    CAS  PubMed  Google Scholar 

  • L Santarelli M Saxe C Gross A Surget F Battaglia S Dulawa N Weisstaub J Lee R Duman O Arancio C Belzung R Hen (2003) ArticleTitleRequirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 805–809 10.1126/science.1083328 Occurrence Handle10.1126/science.1083328 Occurrence Handle1:CAS:528:DC%2BD3sXmtVGqsrY%3D Occurrence Handle12907793

    Article  CAS  PubMed  Google Scholar 

  • J Schumacher RA Jamra T Becker S Ohlraun N Klopp EB Binder TG Schulze M Deschner C Schmal S Hofels A Zobel T Illig P Propping F Holsboer M Rietschel MM Nothen S Cichon (2005) ArticleTitleEvidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression Biol Psychiatry 58 307–314 10.1016/j.biopsych.2005.04.006 Occurrence Handle10.1016/j.biopsych.2005.04.006 Occurrence Handle1:CAS:528:DC%2BD2MXosVCksrY%3D Occurrence Handle16005437

    Article  CAS  PubMed  Google Scholar 

  • A Serretti P Artioli C Lorenzi A Pirovano V Tubazio R Zanardi (2004) ArticleTitleThe C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings Int J Neuropsychopharmacol 7 453–460 10.1017/S1461145704004687 Occurrence Handle10.1017/S1461145704004687 Occurrence Handle1:CAS:528:DC%2BD2cXpsVOqs7o%3D Occurrence Handle15458611

    Article  CAS  PubMed  Google Scholar 

  • SJ Tsai CY Cheng YW Yu TJ Chen CJ Hong (2003) ArticleTitleAssociation study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response Am J Med Genet B Neuropsychiatr Genet 123 19–22 10.1002/ajmg.b.20026 Occurrence Handle10.1002/ajmg.b.20026

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical School, University of Tampere, Tampere, Finland

    S. Anttila, K. Huuhka, M. Huuhka, R. Rontu, E. Leinonen & T. Lehtimäki

  2. Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

    S. Anttila, R. Rontu & T. Lehtimäki

  3. Department of Psychiatry, Tampere University Hospital, Pitkäniemi, Finland

    K. Huuhka, M. Huuhka & E. Leinonen

  4. Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland

    M. Hurme

  5. The Laboratory Centre, Tampere University Hospital, Tampere, Finland

    M. Hurme

Authors
  1. S. Anttila
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Huuhka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Huuhka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Rontu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Hurme
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Leinonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. Lehtimäki
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anttila, S., Huuhka, K., Huuhka, M. et al. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. J Neural Transm 114, 1065–1068 (2007). https://doi.org/10.1007/s00702-007-0705-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-007-0705-9

Search

Navigation