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Echogenic substantia nigra in patients with orthostatic tremor

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Summary.

Objectives: Previous studies suggest that the nigrostriatal dopaminergic transmission is impaired in patients with primary orthostatic tremor. Methods: We used transcranial sonography (TCS) to examine the morphology of the substantia nigra (SN) in four patients with primary orthostatic tremor (OT). Results: TCS revealed an SN echogenicity in all patients, in three patients unilaterally, in one patient bilaterally. Conclusions: Our data suggest nigrostriatal dopaminergic deficits in OT patients. The exact impact of these dopaminergic deficits on OT generation is unclear.

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Authors and Affiliations

  1. Department of Neurology, University of the Saarland, Homburg/Saar, Germany

    J. Spiegel, S. Behnke, G. Fuss, G. Becker & U. Dillmann

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  1. J. Spiegel
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  2. S. Behnke
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  3. G. Fuss
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  4. G. Becker
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  5. U. Dillmann
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Spiegel, J., Behnke, S., Fuss, G. et al. Echogenic substantia nigra in patients with orthostatic tremor. J Neural Transm 112, 915–920 (2005). https://doi.org/10.1007/s00702-004-0236-6

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  • DOI: https://doi.org/10.1007/s00702-004-0236-6

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