Summary.
Transcription factor AP-2β has been suggested to influence brain monoaminergic systems by regulating target genes. In order to explore a possible functional role, AP-2β genotype was analysed in relation to striatal dopamine D2 receptor density determined in vivo by positron emission tomography in human subjects (n = 52). The AP-2β genotype was also analysed in relation to cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA), 3-methoxy-4-hydroxy-phenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) in healthy human subjects (n = 90). There was no association between the AP-2β genotype and measures of dopamine receptor density, or CSF 5-HIAA concentrations. However, AP-2β genotype was associated with CSF-levels of HVA (in women) and MHPG. These data may suggest a functional involvement of AP-2β in the dopaminergic system, but should be interpreted with caution until replicated.
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Damberg, M., Berggård, C., Farde, L. et al. Transcription factor AP-2β genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans. J Neural Transm 111, 537–545 (2004). https://doi.org/10.1007/s00702-003-0097-4
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DOI: https://doi.org/10.1007/s00702-003-0097-4