Abstract
Cerebral amyloid angiopathy (CAA), a cause of recurrent and multiple lobar hemorrhages, characteristically occurs in persons aged ≥55 years. We report a case of a 32-year-old male who had recurrent hemorrhage in the left multiple lobes, with a history of traumatic brain injury and hematoma evacuation at the age of 1 year. He underwent surgical treatment and was histopathologically diagnosed as having CAA. The literature review yielded six CAA cases, including ours, aged less than 55 years. All were male and four had histories of severe TBI, suggesting that male sex and TBI may be associated with CAA in young persons.
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References
Campbell DM, Bruins S, Vogel H, Shuer LM, Wijman CAC (2008) Intracerebral hemorrhage caused by cerebral amyloid angiopathy in a 53-year-old man. J Neurol 255(4):597–598
Ehling R, Helbok R, Beer R, Lackner P, Broessner G, Pfausler B, Röcken C, Aguzzi A, Chemelli A, Schmutzhard E (2012) Recurrent intracerebral haemorrhage after coitus: a case report of sporadic cerebral amyloid angiopathy in a younger patient. Eur J Neurol 19(3):29–31
Fleminger S, Oliver DL, Lovestone S, Rabe-Hesketh S, Giora A (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74(7):857–862
Gilbert JJ, Vinters HV (1983) Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage. Stroke 14(6):915–923
Magnoni S, Brody DL (2010) New perspectives on amyloid-beta dynamics after acute brain injury: moving between experimental approaches and studies in the human brain. Arch Neurol 67(9):1068–1073
Mortimer JA, French LR, Hutton JT, Schuman LM (1985) Head injury as a risk factor for Alzheimer’s disease. Neurology 35(2):264–267
Purrucker JC, Hund E, Ringleb PA, Hartmann C, Rohde S, Schönland S, Steiner T (2013) Cerebral amyloid angiopathy—an underdiagnosed entity in younger adults with lobar intracerebral hemorrhage? Amyloid 20(1):45–47
Shinohara M, DeTure M, Yamazaki Y, Tachibana M, Atagi Y, Davis MD, Liu C-C, Zhao N, Painter MM, Petersen RC, Fryer JD, Crook JE, Dickson DW, Bu G, Kanekiyo T (2016) Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 132(2):225–234
Smith EE, Greenberg SM (2003) Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Curr Atheroscler Rep 5(4):260–266
Wong MP, Ng TH, Chan KH (1991) Cerebral amyloid angiopathy and spontaneous intracerebral haemorrhage. Report of a sporadic case in a young Chinese. Clin Neurol Neurosurg 93(2):133–136
Yamada M (2000) Cerebral amyloid angiopathy: an overview. Neuropathology 1:8–22
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An erratum to this article is available at http://dx.doi.org/10.1007/s00701-016-3047-2.
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Nakayama, Y., Mineharu, Y., Arawaka, Y. et al. Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature. Acta Neurochir 159, 15–18 (2017). https://doi.org/10.1007/s00701-016-3004-0
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DOI: https://doi.org/10.1007/s00701-016-3004-0