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Highly exfoliated functionalized MoS2 with sodium alginate-polydopamine conjugates for electrochemical sensing of cardio-selective β-blocker by voltammetric methods

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Abstract

Molybdenum disulfide (MoS2) surface functionalization was performed with a catechol-containing polymer sodium alginate (SA) and dopamine (DA) through simultaneous MoS2 exfoliation and self-polymerization of DA. The MoS2/SA-PDA nanocomposite was characterized using spectroscopic, microscopic, and electroanalytical techniques to evaluate its electrocatalytic performance. The electrocatalytic behavior of the MoS2/SA-PDA nanocomposite modified electrode for the detection of acebutolol (ACE), a cardio-selective β-blocker drug was explored  through cyclic voltammetric and differential pulse voltammetric techniques. The influence of scan rate, concentration, and pH value on the oxidation peak current of ACE was investigated  to optimize the deducting condition. The electrochemical activity of the MoS2/SA-PDA nanocomposite electrode was attributed to the existence of reactive functional groups being contributed from SA, PDA, and MoS2 exhibiting a synergic effect. The MoS2/SA-PDA nanocomposite modified electrode exhibits admirable electrocatalytic activity with a wide linear response range (0.009 to 520 μM), low detection limit (5 nM), and high sensitivity (0.354 μA μM−1 cm−2) also in the presence of similar (potentially interfering) compounds. The fabricated MoS2/SA-PDA nanocomposite modified electrode can be useful for the detection of ACE in pharmaceutical analysis.

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Author notes

  1. Chung-Yi Lee and Adhimoorthy Prasannan contributed equally to this work.

Authors and Affiliations

  1. Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan

    Chung-Yi Lee, Adhimoorthy Prasannan, Varghese Lincy & Po-Da Hong

  2. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10106, Taiwan

    Subash Vetri Selvi & Shen−Ming Chen

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  1. Chung-Yi Lee
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  2. Adhimoorthy Prasannan
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  3. Varghese Lincy
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  4. Subash Vetri Selvi
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Correspondence to Po-Da Hong.

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Lee, CY., Prasannan, A., Lincy, V. et al. Highly exfoliated functionalized MoS2 with sodium alginate-polydopamine conjugates for electrochemical sensing of cardio-selective β-blocker by voltammetric methods. Microchim Acta 188, 103 (2021). https://doi.org/10.1007/s00604-021-04717-0

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