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In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum

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Abstract

A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/N = 3). The response sensitivity is 3.35 mA mM−1 cm−2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM−1 cm−2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors.

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Funding

This study is funded by the STS Key Project of Fujian Province (2017T3007), Nature Sciences Funding of Fujian Province (2018J01682) and the Project of Quangang District Science and Technology Bureau (2019G01), and Natural Science Foundation of Guangdong Province (2019A1515011799).

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Author notes

  1. Shuisheng Hu and Yuxia Lin contributed equally to this work.

Authors and Affiliations

  1. Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian, 350108, People’s Republic of China

    Shuisheng Hu, Yuxia Lin & Bin Qiu

  2. The State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR, People’s Republic of China

    Shuisheng Hu & Wing-Leung Wong

  3. Department of Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Xiamen Hospital, Beijing University of Chinese Medicine, Xiamen TCM Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China

    Jing Teng

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  1. Shuisheng Hu
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Correspondence to Jing Teng, Wing-Leung Wong or Bin Qiu.

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Hu, S., Lin, Y., Teng, J. et al. In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum. Microchim Acta 187, 670 (2020). https://doi.org/10.1007/s00604-020-04634-8

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