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An electrochemical sensor based on MOF-derived NiO@ZnO hollow microspheres for isoniazid determination

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Abstract

The electrocatalytic activity of metal-organic framework (MOF)-derived NiO@ZnO hollow microspheres was studied for its application to an isoniazid sensor. The MOF-derived NiO@ZnO hollow spheres were synthesized by the coordination reaction of terephthalic acid with Zn2+ and Ni2+ and followed by calcination. Morphology characterization showed that the MOF-derived NiO@ZnO sphere has circular core-shell structure with pores on its surface. Further electrochemical characterization of the prepared sensor by cyclic voltammetry and differential pulse voltammetry proved that the material has good electrical conductivity and strong catalytic ability. Distinct oxidation peaks occur for INZ at potential of 0.22 V (vs. saturated calomel electrode). Under the optimal experimental conditions, the linear range of the sensor for isoniazid determination was 0.8 ~ 800 μM, and the detection limit was 0.25 μM (S/N = 3). In addition, the sensor displayed good stability, repeatability, and reproducibility. The established method was successfully applied for determination of isoniazid in tablets and mouse serum with admirable accuracy and reliability.

Schematic presentation of an electrochemical sensor based on MOF-derived NiO@ZnO hollow microspheres for isoniazid determination.

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Funding

This work was financially supported by Shenzhen Science and Technology Program (KQTD20170810105439418), the Innovative team and talent training project of Shihezi (2018TD02), Innovation and entrepreneurship project for overseas high-level talents of Shenzhen (KQJSCX20180328165437711) and National Natural Science Foundation of China (81773680).

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Author notes

  1. Jingjing Wang, Junhong Zhao and Jiao Yang contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Xinjiang Phytomedicine Resources for Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832000, China

    Jingjing Wang & Yingchun Li

  2. College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China

    Junhong Zhao, Jiao Yang & Yingchun Li

  3. Experiment and Innovation Education Center, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, People’s Republic of China

    Jing Cheng

  4. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518055, China

    Yongzhu Tan & Yingchun Li

  5. College of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China

    Huanhuan Feng

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  1. Jingjing Wang
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  2. Junhong Zhao
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Correspondence to Huanhuan Feng or Yingchun Li.

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Wang, J., Zhao, J., Yang, J. et al. An electrochemical sensor based on MOF-derived NiO@ZnO hollow microspheres for isoniazid determination. Microchim Acta 187, 380 (2020). https://doi.org/10.1007/s00604-020-04305-8

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