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β-Cyclodextrin-/AuNPs-functionalized covalent organic framework-based magnetic sorbent for solid phase extraction and determination of sulfonamides

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Abstract

β-Cyclodextrin-functionalized magnetic covalent organic framework (Fe3O4@COF@Au-β-CD) was developed as sorbent for magnetic solid phase extraction of trace sulfonamides in meat samples prior to HPLC-MS/MS analysis. The sorbent was synthesized by loading gold nanoparticles onto a Fe3O4@COF surface and then functionalized by thiolated-β-cyclodextrin immobilization via Au-S bonding formation. The prepared composite material was employed for sulfonamides extraction. The main parameters were optimized to obtain the best extraction efficiency. The experiments of adsorption kinetics were carried out to investigate the adsorption mechanism. Results showed the pseudo-second-order kinetic was better fitted with the adsorption kinetics of sulfonamides. Under optimized conditions, the magnetic solid phase extraction-HPLC method showed good linearity (R2 ≥ 0.9936), and the limits of detection were in the range of 0.8–1.6 μg kg−1. The proposed method was successfully used for quantitation of sulfonamides in real samples. The recoveries ranged from 78.9 to 112.0% with relative standard deviations (RSDs) < 10% (n = 5). The proposed method exhibited great potential for enrichment and determination of sulfonamides in many other food or environment samples.

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Funding

This work was supported by the Natural Science Foundation of Shandong Province (ZR2017JL012), the National Natural Science Foundation of China (21677085), the Science and Technology Nova Plan of Shaanxi Province (2019KJXX-010), and the Youth Innovation Team of Shaanxi Universities (Food Quality and Safety).

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Authors and Affiliations

  1. School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi’an, 710021, China

    Yan Yang, Guoliang Li & Aying Wen

  2. Key Laboratory of Life-Organic Analysis of Shandong Province, Qufu Normal 13 University, Qufu, 273165, China

    Guoliang Li

  3. Yangtze Delta Region Institute of Tsinghua University, Zhejiang, 314006, China

    Di Wu

  4. NHC Key Laboratory of Food Safety Risk Assessment; Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science; China National Center for 11 Food Safety Risk Assessment, Beijing, 100050, China

    Yongning Wu

  5. Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China

    Xuxia Zhou

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  1. Yan Yang
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Correspondence to Guoliang Li or Xuxia Zhou.

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Yang, Y., Li, G., Wu, D. et al. β-Cyclodextrin-/AuNPs-functionalized covalent organic framework-based magnetic sorbent for solid phase extraction and determination of sulfonamides. Microchim Acta 187, 278 (2020). https://doi.org/10.1007/s00604-020-04257-z

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