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A nanocomposite prepared from hemin and reduced graphene oxide foam for voltammetric sensing of hydrogen peroxide

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Abstract

A foam consisting of reduced graphene oxide was synthesized by a one-pot hydrothermal method. The foam was used to prepare a nanocomposite with hemin which is formed via π-interactions. The nanocomposite was incorporated via a Nafion film and then placed on a glassy carbon electrode (GCE). The modified GCE displays outstanding catalytic activity towards H2O2. It is assumed that this is due to (a) the redox-active center [Fe(III/II)] of hemin, and (b) the crosslinked macroporous structure of the foam. Both improve the electron transfer rate and electrochemical signals. Under the optimum experimental conditions and a working voltage of typically −0.41 mV (vs. SCE), the sensor has a 2.8 nM H2O2 detection limit, and the analytically useful range extends from 5 nM to 5 mM with a sensitivity of 50.5 μA μM−1 cm−2. The modified GCE has high sensitivity and fast response. It was utilized to quantify H2O2 in spiked environmental water samples.

Schematic representation of the electrochemical sensor based on a nanocomposite prepared from hemin and reduced graphene oxide foam, which can be applied to the determination of hydrogen peroxide in serum.

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Acknowledgements

We gratefully acknowledge the financial support from the Shanghai Science and Technology Committee (Grant No. 17070503000, 18dz2308700); Program for Changjiang Scholars and Innovative Research Team in University (IRT_16R49); International Joint Laboratory on Resource Chemistry (IJLRC) and Shanghai Engineering Research Center of Green Energy.

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Authors and Affiliations

  1. The Education Ministry Key Laboratory of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, People’s Republic of China

    Qinglian Li, Yao Zhang, Pengwei Li & Nengqin Jia

  2. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China

    Huaiguo Xue

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  1. Qinglian Li
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  3. Pengwei Li
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Li, Q., Zhang, Y., Li, P. et al. A nanocomposite prepared from hemin and reduced graphene oxide foam for voltammetric sensing of hydrogen peroxide. Microchim Acta 187, 45 (2020). https://doi.org/10.1007/s00604-019-3829-3

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