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Synthesis of hybrid magneto-plasmonic nanoparticles with potential use in photoacoustic detection of circulating tumor cells

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Abstract

This article describes a novel synthetic route to obtain hybrid nanostructures that combine the plasmonic properties of gold nanorods with the magnetic properties of iron oxide nanoparticles in a robust silica nanostructure. The silica matrix enhances the physico-chemical stability of the nanostructure and preserves its magneto-plasmonic properties by avoiding the interface between gold and iron oxide. In addition, the magneto-plasmonic features of the nanohybrids can be tuned due to the independent synthesis of each component. The magnetic and plasmonic properties of these nanostructures can potentially enhance the photoacoustic detection of circulating tumor cells.

Schematic presentation of a hybrid magneto-plasmonic nanoparticle with an Au@Fe3O4@SiO2 core-satellite-shell arrangement. The magnetic and plasmonic responses of this kind of nanostructure enable magnetic trapping and photoacoustic detection of circulating tumor cells.

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Acknowledgements

This work was supported by the Spanish Ministry of Science and Innovation: MAT2015-67557-C2-2-P and MAT2015-67557-C1-2-P.

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Authors and Affiliations

  1. Instituto de Magnetismo Aplicado, ‘Salvador Velayos’, UCM-CSIC-ADIF, Las Rozas, PO Box 155, 28230, Madrid, Spain

    Jesus G. Ovejero, Miguel A. García & Antonio Hernando

  2. Department of Bioengineering, University of Washington, Seattle, Washington, 98195, USA

    Soon Joon Yoon, Junwei Li, Xiaohu Gao & Matthew O’Donnell

  3. Laboratorio de Microscopias Avanzadas (LMA), Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor s/n, 50018, Zaragoza, Spain

    Alvaro Mayoral

  4. Instituto de Cerámica y Vidrio (ICV), CSIC, Kelsen 5, E-28049, Madrid, Spain

    Miguel A. García

  5. Departamento de Química Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco s/n, 28049, Madrid, Spain

    Pilar Herrasti

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  1. Jesus G. Ovejero
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  2. Soon Joon Yoon
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  7. Miguel A. García
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  9. Antonio Hernando
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Correspondence to Jesus G. Ovejero.

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The authors declare that they have no competing interests. This work has been supported by the Spanish Ministry of Science and Innovation: MAT2015-67557-C2-2-P and MAT2015-67557-C1-2-P; and by projects NIH RO1-EB016034, R01-CA170734, RO1-HL121226, RO1-HL125339, the Life Sciences Discovery Fund 3292512, NSF CBET-1236309, and the Department of Bioengineering at the University of Washington.

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Ovejero, J.G., Yoon, S.J., Li, J. et al. Synthesis of hybrid magneto-plasmonic nanoparticles with potential use in photoacoustic detection of circulating tumor cells. Microchim Acta 185, 130 (2018). https://doi.org/10.1007/s00604-017-2637-x

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