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A Surface Enhanced Raman Scattering (SERS) microdroplet detector for trace levels of crystal violet

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Abstract

We report on a microfluidic platform that integrates a winding microdroplet chip and a surface-enhanced Raman scattering (SERS) detection system for trace determination of crystal violet (CV). Colloidal silver was applied to generate SERS. Compared to the continuous flow microfluidic system, the microdroplet based detection described here effectively eliminates any memory effects. Effects of flow pattern, droplet size, surfactant, and position of detection were optimized. Under optimal conditions, there is a linear correlation between signal and the concentration of CV in the 10 nM to 800 nM range, with a correlation coefficient (R2) of 0.9967. The limit of detection in water is 3.6 nM.

A winding microdroplet chip based on SERS detection was developed for trace levels of crystal violet. Under optimal conditions,there is a good linear correlation in the 10 nM to 800 nM range with LOD is 3.6 nM.

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Acknowledgments

This work was supported by National Science Foundation of China (grant No: 21205041, No: 61008003), a grant from Research Center of Analysis and Test of East China University of Science and Technology,China, and Shanghai Rising-Star Program (No: 11QA1402100).

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Authors and Affiliations

  1. Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis and Test, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Bingxiang Liu, Xiaohui Yang, Ting Wu & Yiping Du

  2. Technical Center for Industrial Products and Raw Materials Inspection and Testing, Shanghai Entry-Exit Inspection & Inspection and Quarantine Bureau, Shanghai, 200135, People’s Republic of China

    Wei Jiang & Haiting Wang

  3. State Key Laboratory of Precision Spectroscopy, East China Normal University, North Zhongshan Rd., No.3663, Shanghai, 200062, People’s Republic of China

    Sanjun Zhang & Yufeng Yuan

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  1. Bingxiang Liu
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  2. Wei Jiang
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  3. Haiting Wang
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Correspondence to Ting Wu or Yiping Du.

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Liu, B., Jiang, W., Wang, H. et al. A Surface Enhanced Raman Scattering (SERS) microdroplet detector for trace levels of crystal violet. Microchim Acta 180, 997–1004 (2013). https://doi.org/10.1007/s00604-013-1026-3

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  • DOI: https://doi.org/10.1007/s00604-013-1026-3

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