Abstract
Purpose
Postoperative stress produces an inflammatory response. Recent studies have shown that narcotic analgesics suppress the immune system. Nutritional management during perioperative care has also been reported to affect inflammation. We therefore examined whether remifentanil or glucose administration could ameliorate postsurgical inflammatory responses using a rat model of surgical stress.
Methods
We divided male Wistar rats randomly into five groups: (1) control, (2) sevoflurane+lactated Ringer’s solution, (3) sevoflurane+lactated Ringer’s solution with 1% glucose, (4) sevoflurane+remifentanil+lactated Ringer’s solution, and (5) sevoflurane+remifentanil+ lactated Ringer’s solution with 1% glucose. In all groups, serum samples were obtained at various time points after surgery, and secreted cytokine concentrations were determined. In addition, we assessed the activation of protein kinase B (Akt) and forkhead/winged helix box class O (FOXO3), which play a role in gluconeogenesis/stress responses.
Results
Surgical stress increased the serum concentrations of tumor necrosis factor-α and interleukin-6. Groups receiving remifentanil with anesthesia showed an attenuated inflammatory response. The inflammatory response was also reduced by administering 1% glucose. Furthermore, 1% glucose induced Akt and FOXO3 phosphorylation in the quadriceps femoris muscle 12 h after surgery.
Conclusions
Anesthesia based on remifentanil and perioperative administration of lactated Ringer’s solution containing 1% glucose may be able to control inflammatory responses caused by surgical stress.
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Hasegawa, A., Iwasaka, H., Hagiwara, S. et al. Remifentanil and glucose suppress inflammation in a rat model of surgical stress. Surg Today 41, 1617–1621 (2011). https://doi.org/10.1007/s00595-010-4457-z
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DOI: https://doi.org/10.1007/s00595-010-4457-z