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Group IIA-Soluble Phospholipase A2 Levels in Patients with Infections After Esophageal Cancer Surgery

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Abstract

Purpose

To examine the changes in blood-soluble phospholipase A2-IIA levels caused by surgical stress and postoperative infections.

Methods

We retrospectively analyzed a prospective database of 40 patients who underwent esophagectomy for esophageal cancer. Nine of these patients had a postoperative infection (E Inf(+) group), and 31 did not have a postoperative infection (E Inf(−) group). The blood sPLA2-IIA level was measured using a radioimmunoassay, and whole blood was stimulated with lipopolysaccharide (LPS) to examine the sPLA2-IIA production.

Results

In the E Inf(−) group, the blood sPLA2-IIA levels peaked on postoperative day (POD) 3 then decreased gradually thereafter. Receiver-operator characteristic statistics based on the sPLA2-IIA values on POD 5, which are used to classify postoperative infectious complications, revealed an area under the curve of 0.789. However, stimulation of peripheral blood cells with LPS did not induce the production of sPLA2-IIA.

Conclusion

During the early postoperative phase, blood sPLA2-IIA levels increase according to the surgical stress. Soluble PLA2-IIA may be produced at the site of infection or in the liver, but not in the circulating blood. Sustained elevation of the serum sPLA2-IIA level, observed even after POD 3, seems to represent a response to postoperative infection.

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Authors and Affiliations

  1. Department of Surgery 1, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 020-8505, Japan

    Masaaki Ogawa, Yusuke Kimura, Kenichiro Ikeda & Takeshi Iwaya

  2. Department of Critical Care Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 020-8505, Japan

    Nobuhiro Sato, Shigeatsu Endo, Masahiro Kojika & Yasunori Yaegashi

Authors
  1. Masaaki Ogawa
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  2. Nobuhiro Sato
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  3. Shigeatsu Endo
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  4. Masahiro Kojika
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  5. Yasunori Yaegashi
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  6. Yusuke Kimura
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  7. Kenichiro Ikeda
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  8. Takeshi Iwaya
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Ogawa, M., Sato, N., Endo, S. et al. Group IIA-Soluble Phospholipase A2 Levels in Patients with Infections After Esophageal Cancer Surgery. Surg Today 35, 912–918 (2005). https://doi.org/10.1007/s00595-005-3059-7

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  • DOI: https://doi.org/10.1007/s00595-005-3059-7

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