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TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population

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Abstract

Associations between the TAQIB and I405V polymorphisms and obesity risk were studied for a single locus as well as in combination. A total of 934 obese subjects and 924 normal controls were included in the study. TAQIB was associated with high-density lipoprotein (HDL) levels (P < 0.001), while I405V was associated with levels of low-density lipoprotein (P = 0.03) and total cholesterol (P = 0.007). Less common alleles of TAQIB and I405V were associated with decreased obesity risk and further drops in odds ratio (OR) were observed in carriers with rare homozygous alleles on both loci (OR = 0.659, P = 0.02). The TAQIB B2 allele was associated with reductions in both hip circumference (P = 0.034) and triceps skinfold thickness (TST) (P = 0.045), although this effect was completely abolished after controlling for HDL levels. The 405V variant was associated with reductions in hip circumference (P = 0.031), body fat composition (P = 0.039) and TST (P = 0.036); these effects were weakened (P < 0.1) after controlling for HDL levels. In conclusion, less common alleles of TAQIB and I405V appear to be modestly associated with obesity risk in an adult Chinese population. Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association.

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Acknowledgments

We would like to thank the community, particularly the participants, for taking part in this study. We appreciate the invaluable help of associates in collecting of blood samples and biochemical analyses. This study was supported by the Beijing Hypertension League Institute, in part through an unrestricted educational grant from F. Hoffmann-La Roche, the National Infrastructure Program of Chinese Genetic Resources (2005DKA21300), and the Tsinghua-Yuyuan Medical Science Research Foundation.

Conflict of interest statement

The authors declare no conflicts of interest associated with this manuscript.

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Authors and Affiliations

  1. Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China

    Xiaoyang Ruan, Lina Ma, Shuyu Wang, Lisheng Liu & Xingyu Wang

  2. Department of Microbiology and Biochemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China

    Xiaoyang Ruan & Jinghai Zhang

  3. Roche Center for Medical Genomics, F. Hoffmann-La Roche, Basel, Switzerland

    Klaus Lindpaintner

  4. Department of Biomedical Engineering, School of Medicine, TsingHua University, Beijing, China

    Xiangjun Liu

  5. Center for Genetics, National Research Institute for Family Planning, Beijing, China

    Binbin Wang, Zuoqi Peng & Xu Ma

  6. Department of Genetics, Peking Union Medical College, Beijing, China

    Xu Ma

  7. Department of Pharmaceutical Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China

    Maosheng Cheng

  8. No. 24 ShiJingShan Road, Beijing, China

    Xingyu Wang

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  1. Xiaoyang Ruan
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  2. Lina Ma
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Correspondence to Xingyu Wang.

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Ruan, X., Ma, L., Wang, S. et al. TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population. Acta Diabetol 47, 217–224 (2010). https://doi.org/10.1007/s00592-009-0117-4

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  • DOI: https://doi.org/10.1007/s00592-009-0117-4

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