Abstract
The dairy cattle production rises worldwide, with genetically selected animals. Consequently, they present high nutritional requirements, especially during the transition period. The aim of this study was to evaluate the effects of parenteral supplementation of a mineral blend composed by selenium, copper, magnesium, phosphorus, and potassium on hematological, biochemical, immunological, and antioxidant status in transition period dairy cows and newborn calves. The Holstein cows were divided into the control group (A, n = 3) and treated group (B, n = 4), which were supplemented twice with an intramuscularly dose of 10 mL/animal, at approximately 20 days prior to the parturition, and a subsequent dose at the parturition. Total blood was collected from cows on days 20 and 5 antepartum, and 2 and 7 postpartum, and from calves, at the birth. We observed a decreased in concentrations of thiobarbituric acid reactive substances (TBARSs) for cows fed mineral blend during the transition period (P < 0.05), as well as a greater number of total leukocyte, total protein and globulin levels, and reduction of hemoglobin levels (P < 0.05). The catalase activity was increased in supplemented cows and in its calves (P < 0.05). Therefore, based on these evidences, the parenteral supplementation with mineral provides beneficial effects in pregnant cows and during the transition period, as well as in their calves.
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References
Ali SF, Lebel CP, Bondy SC (1992) Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicol 113:637–648
Barbosa KBF, Costa NMB, Alfenas RCG, De Paula SO, Minim VPR, Bressan J (2010) Estresse oxidativo: conceito, implicações e fatores modulatórios. Rev Nutr 23:629–643
Barreiros ALBS, David JM, David JP (2006) Estresse oxidativo: relação entre geração de espécies reativas de defesa do organismo. Quím Nov. 29:113–123
Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M (1983) Flow cytometric studies of oxidative product formation by neurotrophils: a graded response to membrane stimulation. J Immunol 1130:1910–1917
Bianchi MLP, Antunes LMG (1999) Radicais livres e os principais antioxidantes da dieta. Rev Nutr 12:123–130
Campos R, Lacerda LA, Terra SR, González FHD (2008) Parâmetros hematológicos e níveis de cortisol plasmático em vacas leiteiras de alta produção no sul do brasil. Braz J Vet Res Anim Sci 45:354–361
Cortinhas CS, Júnior JEF, Naves JR, Porcionato MAF, Silva LFP, Rennó FP, Santos MV (2012) Organic and inorganic sources of zinc, copper and selenium in diets for dairy cows: intake, blood metabolic profile, milk yield and composition. Rev Bras Zootec 41:1477–1483
Costa APD, Borges JRJ, Carvalho CB, Albernaz AP, Viana AP (2004) Determinação de leucometria global, proteínas totais, albumina e globulinas no sangue das veias jugular e mamária de vacas leiteiras com mastite. Rev Bras Ciênc Vet 11:88–91
Ferreira ALA, Matsubara LS (1997) Radicais livres: conceitos, doenças relacionadas, sistema de defesa e estresse oxidativo. Rev Assoc Med Bras 43:61–68
García J, Cuesta M, Pedroso R, Rodríguez J, Gutiérrez M, Mollineda Á, Figueredo J, Quinones R (2007) Suplementación parenteral de cobre en vacas gestantes: efecto sobre postparto y terneiros. Rev MVZ Cordobá 12:985–995
Grigolo B, Lisignoli G, Toneguzzi S, Mazzetti I, Facchini A (1998) Copper/zinc superoxide dismutase expression by different human osteosarcoma cell lines. Anticancer Res 18:1175–1180
Gonçalves D, Kozicki LE (1997) Perfis bioquímicos e imunológicos no período peripartal de vacas leiteiras com e sem retenção de placenta. Braz J Vet Res Anim Sci 34:364–370
Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press, Oxford 851p
Horst RL (1986) Regulation of calcium and phosphorus homeostasis in the dairy cow. J Dairy Sci 69:604
Ishler VA (1997) From feed to milk: understanding rumen function. College Agr Sci 27:422
Jarolim P, Lahav M, Liu SC, Palek J (1990) Effect of hemoglobin oxidation products on the stability of red cell membrane skeletons and the associations of skeletal proteins: correlation with a release of hemin. Blood 76:2125–2131
Jentzsch AM, Bachmann H, Furst P, Biesalski HK (1996) Improved analysis of malondialdehyde in human body fluids. Free Rad Biol Med 20:251–256
Koury JC, Donangelo CM (2003) Zinc, oxidative stress and physical activity. Rev Nutr 16:433–441
Lykkesfeldt J, Svendsen O (2006) Oxidants and antioxidants in disease: oxidative stress in farm animals. Vet J 173:502–511
McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049–6055
Miller JK, Slebodzinska EB (1993) Oxidative stress, antioxidants, and animal function. J Dairy Sci 76:2812–2823
Nelson DL, Kiesow LA (1972) Entalpy of the composition of hydrogen peroxide by catalase at 25 °C. Anall Biochem 49:474–479
Rosol C, Capen C (1997) Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorus, magnesium) metabolism. In: Kaneko JJ (ed) Clinical biochemistry of domestic animals, 5 edn. Academic Press, New York, pp. 619–702
Saldanha C, Silva JM (1986) Senescência eritrocitária: interações lipo-proteicas da membrana globular. Acta Médica Portugal 7:131–134
Satter LD, Klopfenstein TJ, Erickson GE, Powel JM (2005) Phosphorus and dairy/beef nutrition. Anim Sci 46:587–606
Shapiro SS, Wilk MB (1965) Na analysis of variance test for normality (complete samples). Biometrika 52:591–611
S’Thiago LRL, Moraes SS, Nicodemo MLF, Rosa IV, Broring N (2000) Efeito do fósforo suplementar sobre o desempenho de vacas de corte em pastagem de Brachiaria humidicola. Pesq Agrop Bras 35:449–456
Slebodzinska EB, Miller KK, Quigley JD, Moore JR (1994) Antioxidant status of dairy cows supplemented prepartum with vitamin e and selenium. J Dairy Sci 77:3087–3095
Sousa JC, Nicodemo MLF, Darsie G (1989) Deficiências minerais em bovinos de roraima, brasil. Cobre e molibdênio. Pesq Agrop Bras 24:1547–1554
Stowe HD, Thomas JW, Johnson T, Marteniuk JV, Morrow JA, Ullrey DE (1988) Responses of dairy cattle to long-term and short-term supplementation with oral selenium and vitamin E. J Dairy Sci 71:1830–1839
Tokarnia CH, Guimarães JÁ, Canela CFC, Dobereiner J (1971) Deficiências de cobre e cobalto em bovinos e ovinos em algumas regiões do Brasil. Pesq Agrop Bras 6:61–77
Vincent HK, Innes KE, Vincent KR (2007) Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obesity and Metabolism 9:813–839
Winck CA, Neto AT (2009) Diagnóstico da adequação de propriedades leiteiras em santa catarina às normas brasileiras de qualidade do leite. Rev Ciênc Agrovet 8:164–172
Zanetti MA, Neunhaus LED, Schalch E, Martins JH (1998) Efeitos da suplementação de selênio e vitamina e em bovinos de leiteiros. Rev Bras Zootec 27:405–408
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The present study was approved by the Ethics Committee for Use of Animals (CEUA) of Universidade do Estado de Santa Catarina, under protocol number 6084160216.
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Soldá, N.M., Glombowsky, P., Campigotto, G. et al. Injectable mineral supplementation to transition period dairy cows and its effects on animal health. Comp Clin Pathol 26, 335–342 (2017). https://doi.org/10.1007/s00580-016-2378-y
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DOI: https://doi.org/10.1007/s00580-016-2378-y