Abstract
Bipolar disorder is a chronic mental illness which is associated with high risk of self-harm and suicide. Lithium carbonate has been suggested as a medicine to control and cure this disease. To overcome the complications related to taking lithium carbonate, nanotechnology has come to the aid of scientists. In this study, pegylated liposomal lithium carbonate nanoparticles were prepared by the reverse phase evaporation method to improve the drug’s therapeutic characteristics as well as lessening its side effects. In order to synthesize pegylated liposomal lithium carbonate, phosphatidylcholine, polyethylene glycol 3350 (PEG3350), cholesterol, and lithium carbonate were mixed. The characterization of synthesized nanoparticles was determined by Zetasizer. Encapsulation and drug loading efficiency and release pattern studies were determined through spectrophotometry method. In addition, serum lithium and creatinine levels of the samples were analyzed. The mean diameter, size distribution, and zeta potential for pegylated liposomal particles containing lithium carbonate and blank pegylated liposomal were determined by Zetasizer equal to 102 nm, 0.458, and −25.1 mV; 284.2 nm, 0.427, and −28.3 mV, respectively. Drug loading and encapsulation efficiency were calculated to be 32.87 and 97.4 %, respectively. The drug release pattern demonstrated that the half-life of the nanodrug was approximately two times higher than the standard drug. The results related to the analysis of serum lithium and creatinine levels indicated that the efficiency of liposomal drug formulation was increased compared to the standard drug. Based on the findings, the nanodrug enjoyed a half-life two times higher than that of the standard drug and an efficiency level equal to it.
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References
Amarnath S, Sharma US (1997) Liposomes in drug delivery: progress and limitations. Int J Pharm 154:123–140
Ani M, Moshtaghie AA, Akbarzadeh S (2005) Changes in biochemical parameters related to lipid metabolism following lithium treatment in rat. Iran Biomed J 9:27–32
Cervantes F, Mesa R, Barosi G (2007) New and old treatment modalities in primary myelofibrosis. Cancer J 13:377–383
Chen CH, Suckling J, Lennox BR, Ooi C, Bullmore ET (2011) A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 13:1–15
Cheng HC, Chang CY, Hsieh FI, Yeh JJ, Chien MY, Pan RN, Deng MC, Liu DZ (2011) Effects of tremella-alginate-liposome encapsulation on oral delivery of inactivated H5N3 vaccine. J Microencapsul 28:55–61
Cheong I, Zhou S (2009) Tumor-specific liposomal drug release mediated by liposomase. Methods Enzymol 465:251–265
Christian GD (2002) Reagents for lithium electrodes and sensors for blood serum analysis. Sensors 2:432–435
Chudal R, Sucksdorff D, Suominen A, Lehti V, Hinkka-Yli-Salomäki S, Huttunen J, Ristkari T, Gissler M, McKeague IW, Brown AS, Sourander A (2014) Finnish prenatal study of bipolar disorders (FIPS-B): overview, design and description of the sample. Nord J Psychiatry 68:169–179
Clough Z, Henry R, Ekelund A (2014) Delirium associated with therapeutic levels of lithium in bipolar disorder. Prog Neurol Psychiatry 18:10–12
Costantino L, Boraschi D (2012) Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents? Drug Discov Today 17:367–378
Dikpati A, Madgulkar AR, Kshirsagar SJ, Bhalekar MR, Singh Chahal A (2012) Targeted drug delivery to CNS using nanoparticles. J Adv Pharm Sci 2:79–191
Espirito Santo CE, Carvalho TMJP (2014) Determination of serum lithium: comparison between atomic emission and absorption spectrometry methods. J Bras Patol Med Lab 49:12
Fountoulakis KN, Kelsoe JR, Akiskal H (2012) Receptor targets for antidepressant therapy in bipolar disorder: an overview. J Affect Disord 138:222–238
Fukumoto T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S (2001) Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berlin) 158:100–106
Geddes JR, Miklowitz DJ (2013) Treatment of bipolar disorder. Lancet 381:1672–1682
Goodwin GM, Consensus Group of the British Association for Psychopharmacology (2009) Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology. J Psychopharmacol 23:346–388
Handa T, Naito S, Hiramatsu M, Tsuboi M (2006) Thermal SiO and H13CO+ line observations of the dense molecular cloud G0.11-0.11 in the galactic center region. Astrophys J 636:261–266
Himanshu A, Sitasharan P, Singhai AK (2011) Liposomes as drug carriers. IJPLS 2:945–951
Irache JM, Esparza I, Gamazo C, Agüeros M, Espuelas S (2011) Nanomedicine: novel approaches in human and veterinary therapeutics. Vet Parasitol 180:47–71
Italia JL, Bhatt DK, Bhardwaj V, Tikoo K, Kumar MN (2007) PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral. J Control Release 119:197–206
Iwanaga K, Ono S, Narioka K, Kakemi M, Morimoto K, Yamashita S, Namba Y, Oku N (1999) Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome’ssurface on the GI transit of insulin. J Pharm Sci 88:248–252
Jurgons R, Seliger C, Hilpert A, Trahms L, Odenbach S, Alexiou C (2006) Drug loaded magnetic nanoparticles for cancer therapy. J Phys Condens Matter 18:S2893–S2902
Kawai F (2002) Microbial degradation of polyethers. Appl Microbiol Biotechnol 58:30–38
Lasic DD (1998) Novel applications of liposomes. Trends Biotechnol 16:307–321
Leyhe T, Eschweiler GW, Stransky E, Gasser T, Annas P, Basun H, Laske C (2009) Increase of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease. J Alzheimers Dis 16:649–656
Lian T, Ho RJ (2001) Trends and developments in liposome drug delivery systems. J Pharm Sci 90:667–680
Madetoja J, Madetoja M, Mäkinen J, Riuttala E, Jokinen J (2009) Blood sampling from the tail vein, in comparison with two other techniques, causes less stress to mice. Scand J Lab Anim Sci 36:215–221
Masserini M (2013) Nanoparticles for brain drug delivery. ISRN Biochem 2013:18
Michelon L, Vallada H (2005) Fatores genéticos e ambientais na manifestação do transtorno bipolar. Rev Psiq Clin 32:21–27
Mu L, Feng SS (2003) PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio. Pharm Res 20:1864–1872
Nakase I, Lai H, Singh NP, Sasaki T (2008) Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation. Int J Pharm 354:28–33
Ning Z, Cheung CS, Fu J, Liu MA, Schnell MA (2006) Experimental study of environmental tobacco smoke particles under actual indoor environment. Sci Total Environ 367:822–830
Ochekpe NA, Olorunfemi PO, Ngwuluka NC (2009) Nanotechnology and drug delivery. Part 1: background and applications. Trop J Pharm Res 8:265–274
Olya S, Khorvash M, Rahmani HR, Esmaeilkhanian S, Olya B, Sadri H (2014) Oral delivery of insulin-loaded nanoparticles in diabetic rabbits and in sheep. Czech J Anim Sci 59:251–256
Otsuka H, Nagasaki Y, Kataoka K (2012) PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Deliv Rev 64:246–255
Sadock BJ, Sadock VA, Ruiz P (2009) Kaplan and Sadock’s comprehensive textbook of psychiatry (2 volume set). Lippincott Williams & Wilkins (LWW), Philadelphia
Shallie PD, Adefule AK, Akpan HB, Fakoya D, Adejumo EN (2010) Analysis of some lipid parameters following lithium administration. Afr J Pharm Pharacol 4:202–206
Smith AJ, Kim SH, Duggirala NK, Jin J, Wojtas L, Ehrhart J, Giunta B, Tan J, Zaworotko MJ, Shytle RD (2013) Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Mol Pharm 10:4728–4738
William ZP, Leo EH (2006) Antipsychotic agents & lithium. In: Bertram G (ed) Basic and clinical pharmacology America: K LANGE medical book. McGraw-Hill Companies, Columbus, pp 490–495
Yang T, Choi MK, Cui FD, Kim JS, Chung SJ, Shim CK, Kim DD (2007) Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome. J Control Release 120:169–177
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Hosseini, Y., Alavi, S.E., Akbarzadeh, A. et al. Improving lithium carbonate therapeutics by pegylated liposomal technology: an in vivo study. Comp Clin Pathol 25, 211–218 (2016). https://doi.org/10.1007/s00580-015-2172-2
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DOI: https://doi.org/10.1007/s00580-015-2172-2