Abstract
The excretion of trifluoroacetic acid (TFAA) in bile, saliva and gastric juice of two groups of guinea pigs with bile fistulae was measured by ion-chromatography during inhalation of halothane (0.25% and 1.0% ) for two hours and after inhalation of halothane. In another two groups without bile fistulae, excretion of TFAA was measured in saliva and gastric juice during and after inhalation of same concentrations of halothane.
The excretion of TFAA increased with time and showed the highest concentrations in the saliva. The highest excretion rate and cumulative amounts of excreted TFAA were observed in bile. The cumulative amounts of TFAA excreted into the bile, saliva and gastric juice was 4.85±1.87 μmol, 0.89±0.62 μmol, 0.11 ± 0.06 μmol, respectively, after inhalation of 0.25% halothane and 5.36±2.29 μmol, 1.50±0.59 μmol, 0.25±0.19 μmol, respectively, after inhalation of 1.0% halothane. The excretion of TFAA in bile and saliva was saturated after inhalation of the higher concentration of halothane. The excretion of TFAA into the gastric juice was higher with 1.0% concentration of halothane and in animals without bile fistulae.
We concluded that TFAA a metabolite of halothane is excreted not only in bile but also in saliva and gastric juice. Biotransformation of halothane in salivary glands seems very likely. A small amount of TFAA excreted in bile enters the enterohepatic circulation. The excretion of TFAA in digestive juice seems to be controlled by a rate-limiting mechanism.
Similar content being viewed by others
References
Cohen EN: Metabolism of volatile anesthetics. Anesthesiology 35:193–201, 1971
Jordanov JG: Halothane biotransformation and hepatotoxicity. Hiroshima J Anesthesia 20:3–15, 1984
Mukai S, Morio M, Fujii K and Hanaki C: Volatile metabolites of halothane in the rabbit. Anesthesiology 47:248–251, 1977
Cohen EN, Trudell JR, Edmunds HR and Watson E: Urinary metabolites of halothane in man. Anesthesiology 43:392–402, 1975
Stier A: Trifl.uoroacetic acid as a metabolite of halothane. Biochem Pharmacol 13:15–44, 1964
Fiserova-bergerova V and Kawiecki RW: Effects of exposure concentrations on distribution of halothane metabolites in the body. Drug Metab Dispos 12:98–106, 1984
Cascorbi HF, Blake DA and Helrich M: Differences in the biotransformation of halothane in man. Anesthesiology 32:119–124, 1970
Morio M, Fujii K, Takiyama R, Chikasue F, Kikuchi H and Ribaric L: Quantitative analysis of trifluoroacetate in the urine and blood by Isotachophoresis. Anesthesiology 53:56–59, 1980
Kikuchi H, Morio M, Fujii K, Okida M, Kawamoto M, Inoue T, Yamanoue T, Takiyama Rand Ficor F: Excretion pathways of trifluoroacetate, aerobic metabolite of halothane. Book of abstracts, 8 WCA, Vol.II, A278, (Manila, Philippines), 1984
Cohen EN and Hood N: Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anesthetics in the mouse. Anesthesiology 31:553–559, 1969
Okida M, Kikuchi H, and Fujii K: Concentration dependence of halothane metabolism in rabbits. HIJM 35-2:15–21, 1986
Sawyer DC, Eger EI, Bahlman SH, Cullen BF and Impelman D: Concentration dependence of hepatic halothane metabolism. Anesthesiology 34:230–236, 1971
Murakami K, Ishikawa T, Shimosato T, Noshiro S, Hayashi S and Okuda K: Aryl hydrocarbon hydroxylase activity in rat submandibular glands. J Dent Res 65:39–43,1986
Author information
Authors and Affiliations
About this article
Cite this article
Mirkov, M.I., Morio, M., Kawahara, M. et al. Excretion of trifluoroacetic acid as a metabolite of halothane in digestive juices. J Anesth 2, 133–138 (1988). https://doi.org/10.1007/s0054080020133
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s0054080020133