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TRPV4 ion channel as important cell sensors

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Abstract

This review provides a summary of the physiological significance of the TRPV4 ion channel. Although TRPV4 was initially characterized as an osmosensor, we found that TRPV4 can also act as a thermosensor or a mechanosensor in brain neurons or epithelial cells in the urinary bladder. Here, we summarize the newly characterized functions of TRPV4, including the research progress that has been made toward our understanding of TRPV4 physiology, and discuss other recent data pertaining to TRPV4. It is thought that TRPV4 may be an important drug target based on its broad expression patterns and important physiological functions. Possible associations between diseases and TRPV4 are also discussed.

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Acknowledgments

The author acknowledges the following funding sources: Grants-in-Aid for Scientific Research (KAKENHI Project No. 15H05934 ‘Thermal Biology’ and 15H03000) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; by a Grant from Uehara Memorial Foundation; by a Grant from Takeda Science Foundation, Tokyo, Japan; by a Grant from the Sumitomo Foundation; by a Grant from the Brain Science Foundation; by a Grant from Narishige Neuroscience Research Foundation; by a Grant from Salt Science Research Foundation No. 14C2; and by a Grant from the Ichiro Kanehara Foundation.

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  1. Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan

    Koji Shibasaki

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  1. Koji Shibasaki
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Correspondence to Koji Shibasaki.

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Shibasaki, K. TRPV4 ion channel as important cell sensors. J Anesth 30, 1014–1019 (2016). https://doi.org/10.1007/s00540-016-2225-y

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