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Coronary artery spasm occurring in the setting of the oculocardiac reflex

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Abstract

The oculocardiac reflex (OCR) occurs in up to 90% of ophthalmological surgeries. Several preventive and treatment strategies have been described. Coronary artery spasm (CAS) plays an important role in the pathogenesis of variant angina and myocardial infarction. We describe an unusual case of a perioperative myocardial infarction due to CAS that occurred in the setting of the treatment of the OCR. We offer insight aimed at minimizing the deleterious effects of the OCR and its management.

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References

  1. Warner MA, Shields SE, Chute CG. Major morbidity and mortality within 1 month of ambulatory surgery and anesthesia. JAMA. 1993;270:1437–41.

    Article  CAS  PubMed  Google Scholar 

  2. Schein OD, Katz J, Bass EB, Tielsch JM, Lubomski LH, Feldman MA, Petty BG, Steinberg EP. The value of routine preoperative medical testing before cataract surgery. Study of Medical Testing for Cataract Surgery. N Engl J Med. 2000;342:168–75.

    Article  CAS  PubMed  Google Scholar 

  3. McCannel CA, Nordlund JR, Bacon D, Robertson DM. Perioperative morbidity and mortality associated with vitreoretinal and ocular oncologic surgery performed under general anesthesia. Trans Am Ophthalmol Soc. 2003;101:209–13 (discussion 13–5).

    PubMed  Google Scholar 

  4. Adesanya AO, de Lemos JA, Greilich NB, Whitten CW. Management of perioperative myocardial infarction in noncardiac surgical patients. Chest. 2006;130:584–96.

    Article  PubMed  Google Scholar 

  5. Khavandi A, Gatward JJ, Whitaker J, Walker P. Myocardial infarction associated with the administration of intravenous ephedrine and metaraminol for spinal-induced hypotension. Anaesthesia. 2009;64:563–6.

    Article  CAS  PubMed  Google Scholar 

  6. Okumura K, Yasue H, Horio Y, Takaoka K, Matsuyama K, Kugiyama K, Fujii H, Morikami Y. Multivessel coronary spasm in patients with variant angina: a study with intracoronary injection of acetylcholine. Circulation. 1988;77:535–42.

    CAS  PubMed  Google Scholar 

  7. Hahnenkamp K, Honemann CW, Fischer LG, Durieux ME, Muehlendyck H, Braun U. Effect of different anaesthetic regimes on the oculocardiac reflex during paediatric strabismus surgery. Paediatr Anaesth. 2000;10:601–8.

    CAS  PubMed  Google Scholar 

  8. Blanc VF, Hardy JF, Milot J, Jacob JL. The oculocardiac reflex: a graphic and statistical analysis in infants and children. Can Anaesth Soc J. 1983;30:360–9.

    Article  CAS  PubMed  Google Scholar 

  9. Yamashita M. Oculocardiac reflex and the anesthesiologist. Middle East J Anesthesiol. 1986;8:399–415.

    CAS  PubMed  Google Scholar 

  10. Bassenge E, Heusch G. Endothelial and neuro-humoral control of coronary blood flow in health and disease. Rev Physiol Biochem Pharmacol. 1990;116:77–165.

    CAS  PubMed  Google Scholar 

  11. Matsuda K, Teragawa H, Fukuda Y, Ueda K, Higashi Y, Sakai K, Miura F, Hirao H, Yamagata T, Yoshizumi M, Chayama K. Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol. 2003;92:1394–8.

    Article  CAS  PubMed  Google Scholar 

  12. Sidi A, Dahleen L, Gaspardone A. Coronary vasospasm during anesthesia induction: awareness, recognition, possible mechanisms, anesthetic factors, and treatment. J Clin Anesth. 2008;20:64–9.

    Article  PubMed  Google Scholar 

  13. Lustik SJ, Chhibber AK, van Vliet M, Pomerantz RM. Ephedrine-induced coronary artery vasospasm in a patient with prior cocaine use. Anesth Analg. 1997;84:931–3.

    Article  CAS  PubMed  Google Scholar 

  14. Nakao K, Ohgushi M, Yoshimura M, Morooka K, Okumura K, Ogawa H, Kugiyama K, Oike Y, Fujimoto K, Yasue H. Hyperventilation as a specific test for diagnosis of coronary artery spasm. Am J Cardiol. 1997;80:545–9.

    Article  CAS  PubMed  Google Scholar 

  15. Houston MC, Hodge R. Beta-adrenergic blocker withdrawal syndromes in hypertension and other cardiovascular diseases. Am Heart J. 1988;116:515–23.

    Article  CAS  PubMed  Google Scholar 

  16. Engelman RM, Hadji-Rousou I, Breyer RH, Whittredge P, Harbison W, Chircop RV. Rebound vasospasm after coronary revascularization in association with calcium antagonist withdrawal. Ann Thorac Surg. 1984;37:469–72.

    Article  CAS  PubMed  Google Scholar 

  17. Arole A, Kroll HR, Brown M. Coronary vasospasm leading to an acute myocardial infarction after the administration of dolasetron. J Clin Anesth. 2005;17:72–4.

    Article  CAS  PubMed  Google Scholar 

  18. Enders JM, Dobesh PP, Ellison JN. Acute myocardial infarction induced by ephedrine alkaloids. Pharmacotherapy. 2003;23:1645–51.

    Article  PubMed  Google Scholar 

  19. Landesberg G. The pathophysiology of perioperative myocardial infarction: facts and perspectives. J Cardiothorac Vasc Anesth. 2003;17:90–100.

    Article  PubMed  Google Scholar 

  20. Martinez EA, Kim LJ, Faraday N, Rosenfeld B, Bass EB, Perler BA, Williams GM, Dorman T, Pronovost PJ. Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemia. Crit Care Med. 2003;31:2302–8.

    Article  PubMed  Google Scholar 

  21. Gillum RF, Fortmann SP, Prineas RJ, Kottke TE. International diagnostic criteria for acute myocardial infarction and acute stroke. Am Heart J. 1984;108:150–8.

    Article  CAS  PubMed  Google Scholar 

  22. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, Katus HA, Newby LK, Ravkilde J, Chaitman B, Clemmensen PM, Dellborg M, Hod H, Porela P, Underwood R, Bax JJ, Beller GA, Bonow R, Van der Wall EE, Bassand JP, Wijns W, Ferguson TB, Steg PG, Uretsky BF, Williams DO, Armstrong PW, Antman EM, Fox KA, Hamm CW, Ohman EM, Simoons ML, Poole-Wilson PA, Gurfinkel EP, Lopez-Sendon JL, Pais P, Mendis S, Zhu JR, Wallentin LC, Fernandez-Aviles F, Fox KM, Parkhomenko AN, Priori SG, Tendera M, Voipio-Pulkki LM, Vahanian A, Camm AJ, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Widimsky P, Zamorano JL, Morais J, Brener S, Harrington R, Morrow D, Lim M, Martinez-Rios MA, Steinhubl S, Levine GN, Gibler WB, Goff D, Tubaro M, Dudek D, Al-Attar N. Universal definition of myocardial infarction. Circulation. 2007;116:2634–53.

    Article  PubMed  Google Scholar 

  23. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–69.

    Article  CAS  PubMed  Google Scholar 

  24. Das G. Therapeutic review. Cardiac effects of atropine in man: an update. Int J Clin Pharmacol Ther Toxicol. 1989;27:473–7.

    CAS  PubMed  Google Scholar 

  25. Kinsella SM, Tuckey JP. Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex. Br J Anaesth. 2001;86:859–68.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Henry R. Kroll.

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Kroll, H.R., Arora, V. & Vangura, D. Coronary artery spasm occurring in the setting of the oculocardiac reflex. J Anesth 24, 757–760 (2010). https://doi.org/10.1007/s00540-010-0967-5

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  • DOI: https://doi.org/10.1007/s00540-010-0967-5

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