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Effects of traditional “Juci” (contralateral acupuncture) on orofacial nociceptive behavior in the rat

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Abstract

Purpose

“Juci”, one of the traditional acupuncture techniques, means contralateral acupuncture; i.e., implanting a needle into an acupoint to treat a given disease or disorder, but on the side of the body opposite to the diseased side. The aim of this study was: (1) to assess acupuncture effects on formalin-induced nociceptive behavior in the orofacial region in the rat, and (2) to evaluate the efficacy of Juci in the orofacial formalin test.

Methods

Forty-four adult male Wistar rats were used in the present study. A 1.0% formalin solution (25 µl s.c., diluted in saline) was injected into the right upper lip. The rats were randomly assigned to five groups. (1) The control group (n = 9), which received formalin injection without acupuncture pretreatment; (2) the ipsilateral Ho-ku (see note below) acupuncture group (n = 10); (3) the contralateral Ho-ku acupuncture group (n = 11); (4) the acupuncture plus naloxone group (n = 9), where intraperitoneal naloxone (1.0 mg·kg−1) was injected immediately before acupuncture pretreatment; and (5) the sham acupuncture group (n = 5). “Ho-ku” is the term used for the “Large Intestine 4” acupoint, located between the first and second metacarpal bones.

Results

The injection of formalin produced the characteristic biphasic behavioral response. Acupuncture significantly inhibited the response in the early and late phases. Naloxone significantly reversed these effects. There were no statistically significant differences between the ipsilateral and Juci acupuncture groups. Sham acupuncture did not exert any significant effect on the formalin-induced behavior.

Conclusion

Our results showed that the degree of effectiveness of Juci was similar to that of the ipsilateral acupuncture technique. Therefore, the Juci technique is also useful for the treatment of orofacial pain.

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Authors and Affiliations

  1. Division of Anesthesiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan

    Kosuke Miura & Koji Sumikawa

  2. Division of Oral and Maxillofacial Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Tomohiro Ohara

  3. Division of Integrative Sensory Physiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Kosuke Miura, Tomohiro Ohara, Jorge L Zeredo, Yukio Okada & Kazuo Toda

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  1. Kosuke Miura
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  2. Tomohiro Ohara
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  3. Jorge L Zeredo
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  4. Yukio Okada
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  5. Kazuo Toda
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  6. Koji Sumikawa
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Miura, K., Ohara, T., Zeredo, J. et al. Effects of traditional “Juci” (contralateral acupuncture) on orofacial nociceptive behavior in the rat. J Anesth 21, 31–36 (2007). https://doi.org/10.1007/s00540-006-0443-4

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  • DOI: https://doi.org/10.1007/s00540-006-0443-4

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