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Sphincter of Oddi manometry using guide-wire-type manometer is feasible for examination of sphincter of Oddi motility

  • Original Article—Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Background

Sphincter of Oddi manometry (SOM) is recognized as the standard diagnostic modality for sphincter of Oddi dysfunction (SOD). However, SOM is not commonly performed because of its technical difficulty and the high incidence of post-procedural pancreatitis. To diminish post-procedural pancreatitis, we tried to develop a new method of SOM. This study examined the feasibility of SOM with a guide-wire-type manometer, which is commonly used to measure the arterial pressure for coronary angiography, for the assessment of SO motility.

Methods

A total of 35 procedures were performed in 8 patients with biliary type III SOD and 14 patients with other disease. We performed SOM using the guide-wire-type manometer on SOD cases and other cases [amplitude, duration, frequency and the area under the curve (AUC) of SO contractions].

Results

The mean time required for the measurement was 7.5 ± 4.1 min. The amplitude, frequency and AUC of SO contractions were significantly larger in the SOD cases than in other diseases (147.2 vs. 92.8 mmHg, p = 0.042; 10 vs. 5/min, p = 0.007; 2,837 vs. 1,122 mmHg s, p = 0.003, respectively). In 6 patients who underwent endoscopic sphincterotomy (EST), the SO amplitude decreased dramatically after EST. In this study, mild pancreatitis was observed in only one patient.

Conclusions

SOM using a guide-wire-type manometer is safe, reliable and easy to apply for the clinical assessment of SO motility. The guide-wire-type manometer may become a new method to measure SO function for the diagnosis of SOD.

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Acknowledgments

This work was supported in part by grants for the Research Committee of Intractable Pancreatic Diseases (Principal investigator: Tooru Shimosegawa) provided by the Ministry of Health, Labour and Welfare of Japan (S.K., H.S., A.M. and H.K.).

Conflict of interest

We declare that we have no conflicts of interest.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Saori Kakuyama, Kentaro Nobutani, Atsuhiro Masuda, Hideyuki Shiomi, Tsuyoshi Sanuki, Maki Sugimoto, Masaru Yoshida, Yoshifumi Arisaka, Tsuyoshi Fujita, Takanobu Hayakumo, Takeshi Azuma & Hiromu Kutsumi

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  1. Saori Kakuyama
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  2. Kentaro Nobutani
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  3. Atsuhiro Masuda
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Correspondence to Hiromu Kutsumi.

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Kakuyama, S., Nobutani, K., Masuda, A. et al. Sphincter of Oddi manometry using guide-wire-type manometer is feasible for examination of sphincter of Oddi motility. J Gastroenterol 48, 1144–1150 (2013). https://doi.org/10.1007/s00535-012-0710-0

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  • DOI: https://doi.org/10.1007/s00535-012-0710-0

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