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Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan

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Abstract

Background

Interleukin-1β (IL-1β) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. However, little information is available about the genetic risk factors of reflux esophagitis. In this study we investigated its association with the IL-1β polymorphisms.

Methods

We examined 48 patients with reflux esophagitis and 96 control subjects, 89 with gastric cancer. IL-1β-511C/T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results

The frequency of IL-1β-511T alleles was significantly higher in reflux esophagitis patients (57.3%) than in controls (41.1%) (P = 0.0215, χ2 = 5.289). The frequency of IL-1β-511T/T genotypes was also significantly higher in reflux esophagitis patients (31.3%) than in controls (15.6%). The odds ratio and the 95% confidence interval were 4.000 and 1.393–11.486, respectively. The frequency of IL-1β-511T/T genotypes was significantly higher in reflux esophagitis patients (31.3%) than in gastric cancer patients (21.4%). The odds ratio and the 95% confidence interval were 2.961 and 1.054–8.316, respectively.

Conclusions

IL-1β-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka-cho, Yoshida-gun, Fukui, 910-1193, Japan

    Atsushi Muramatsu, Takeshi Azuma, Tomoyuki Okuda, Satoko Satomi, Masahiro Ohtani, Soshoku lee, Yoshiyuki Ito & Masaru Kuriyama

  2. Department of Endoscopic Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

    Hiroyuki Suto & Yukinao Yamazaki

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  1. Atsushi Muramatsu
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  2. Takeshi Azuma
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  3. Tomoyuki Okuda
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  4. Satoko Satomi
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  7. Hiroyuki Suto
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  10. Masaru Kuriyama
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Muramatsu, A., Azuma, T., Okuda, T. et al. Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan. J Gastroenterol 40, 873–877 (2005). https://doi.org/10.1007/s00535-005-1672-2

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  • DOI: https://doi.org/10.1007/s00535-005-1672-2

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