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Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw

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Abstract

Purpose

Cancer and its therapies can have a significant impact on general and oral health and, therefore, cause a reduction in patients' quality of life (QoL). The study aimed to evaluate the QoL of cancer patients who use antiresorptive and anti-angiogenic medications with or without the development of medication-related osteonecrosis of the jaws (MRONJ).

Methods

Sixty-two patients diagnosed with cancer under antiresorptive therapy answered three instruments from the European Organization for Cancer Research and Treatment (EORTC). The first questionnaire (QLQ-C30) aimed to measure the overall QoL, the second (QLQ-ELD14) is a complementary module for elderly patients, and the third (QLQ-OH15) aimed to assess oral health related to QoL.

Results

The mean age of the patients was 62.19 years, and 12.9% developed MRONJ. There was no significant difference between sex and MRONJ. Among the QLQ-C30 scales, the item “role functioning (RF2)” presented a significant result (p = 0.019). Those patients without MRONJ had a better function performance both in their daily chores and in their free time. Age was not associated to MRONJ, although some concerns are common to the elderly and cancer patients. QoL related to oral health presented a significant result (p = 0.048) showing that MRONJ has a negative impact on patients’ QoL.

Conclusion

Our results showed that MRONJ has a significant impact on the general and oral QoL of cancer patients, and therefore prevention and awareness must be a priority.

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Data availability

All material and data related to the research are available.

Code availability

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Funding

This study was supported by resources from CAPES – Coordination of Higher Education Improvement.

Author information

Authors and Affiliations

  1. Postgraduate Program in Dentistry, Universidade Federal Do Paraná, Curitiba, Paraná, Brazil

    Sara de Cassia Tornier & Juliana Lucena Schussel

  2. Department of Oral and Maxillofacial Surgery, Erasto Gaertner Cancer Center, Curitiba, Paraná, Brazil

    Fernanda Joly Macedo, Laurindo Moacir Sassi & Juliana Lucena Schussel

Authors
  1. Sara de Cassia Tornier
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  2. Fernanda Joly Macedo
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  3. Laurindo Moacir Sassi
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  4. Juliana Lucena Schussel
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Contributions

S.C. Tornier was responsible for data collection, results analysis, and writing of the manuscript; F.J. Macedo was responsible for data collection and results analysis; L.M. Sassi was responsible for study design, conceptual idea, and revision of the manuscript; J.L. Schussel was responsible for study design, conceptual idea, and writing and revision of the manuscript.

Corresponding author

Correspondence to Juliana Lucena Schussel.

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Ethics approval

This study was approved by the Research Ethics Committee of the Erasto Gaertner Cancer Center on registration 65123116.1.0000.0098 and indexed in the national database of records involving research in human beings.

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All participants signed an informed consent form before participating in the study.

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The manuscript has been seen and approved by all authors, and the material was not previously published.

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The authors declare no competing interests.

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de Cassia Tornier, S., Macedo, F.J., Sassi, L.M. et al. Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw. Support Care Cancer 29, 6713–6719 (2021). https://doi.org/10.1007/s00520-021-06275-w

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  • DOI: https://doi.org/10.1007/s00520-021-06275-w

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