Skip to main content

Advertisement

SpringerLink
Log in

Diagnostic-driven antifungal approach in neutropenic patients at high risk for chronic disseminated candidiasis: preliminary observations on the role of 1,3-β-D-glucan antigenemia and multiphasic contrast-enhanced computed tomography

  • Letter to the editor
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Blade J, Lopez-Guillermo A, Rozman C, Grañena A, Bruguera M, Bordas J, Cervantes F, Carreras E, Sierra J, Montserrat E (1992) Chronic systemic candidiasis in acute-leukemia. Ann Hematol 64(5):240–244

    Article  CAS  Google Scholar 

  2. Voneiff M et al (1990) Hepatosplenic candidiasis, a late manifestation of Candida septicemia in neutropenic patients with hematologic malignancies. Blutalkohol 60(4):242–248

    CAS  Google Scholar 

  3. Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, Bearden DT (2006) Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis 43(1):25–31

    Article  CAS  Google Scholar 

  4. Odabasi Z et al (2004) Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis 39(2):199–205

    Article  CAS  Google Scholar 

  5. Metser U, Haider MA, Dill-Macky M, Atri M, Lockwood G, Minden M (2005) Fungal liver infection in immunocompromised patients: depiction with multiphasic contrast-enhanced helical CT. Radiology 235(1):97–105

    Article  Google Scholar 

  6. De Pauw B et al (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 46(12):1813–1821

    Article  Google Scholar 

  7. Ruhnke M, Böhme A, Buchheidt D, Cornely O, Donhuijsen K, Einsele H, Enzensberger R, Hebart H, Heussel CP, Horger M, Hof H, Karthaus M, Krüger W, Maschmeyer G, Penack O, Ritter J, Schwartz S, Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (2012) Diagnosis of invasive fungal infections in hematology and oncology-guidelines from the Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (AGIHO). Ann Oncol 23(4):823–833

    Article  CAS  Google Scholar 

  8. Picardi M, Pagliuca S, Chiurazzi F, Iula D, Catania M, Rossano F, Pane F (2012) Early ultrasonographic finding of septic thrombophlebitis is the main indicator of central venous catheter removal to reduce infection-related mortality in neutropenic patients with bloodstream infection. Ann Oncol 23:2122–2128

    Article  CAS  Google Scholar 

  9. Picardi M, Soricelli A, Grimaldi F, Nicolai E, Gallamini A, Pane F (2011) Fused FDG–PET/contrast-enhanced CT detects occult subdiaphragmatic involvement of Hodgkin’s lymphoma thereby identifying patients requiring six cycles of anthracycline-containing chemotherapy and consolidation radiation of spleen. Ann Oncol 22:671–680

    Article  CAS  Google Scholar 

  10. Tissot, F., et al. (2013) beta-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Am J Respir Crit Care Med 188(9): p. 1100–9

  11. Della Pepa R et al (2016) Successful management of chronic disseminated candidiasis in hematologic patients treated with high-dose liposomal amphotericin B: a retrospective study of the SEIFEM registry. Support Care Cancer 24(9):3839–3845

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Medicine and Surgery, Federico II University, Via Sergio Pansini, 5, 80131, Naples, Italy

    Roberta Della Pepa, Claudio Cerchione, Novella Pugliese & Fabrizio Pane

  2. Department of Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy

    Roberta Colicchio & Paola Salvatore

  3. CEINGE, Biotecnologie Avanzate s.c.ar.l., Naples, Italy

    Paola Salvatore

  4. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy

    Cesare Sirignano & Ernesto Soscia

  5. Institute of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy

    Livio Pagano

  6. Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy

    Maurizio Sanguinetti

  7. Department of Advanced Biomedical Science, Federico II University, Naples, Italy

    Marco Picardi

Authors
  1. Roberta Della Pepa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudio Cerchione
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Novella Pugliese
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roberta Colicchio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paola Salvatore
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cesare Sirignano
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ernesto Soscia
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Livio Pagano
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Maurizio Sanguinetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Fabrizio Pane
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Marco Picardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roberta Della Pepa.

Ethics declarations

Conflict of interest

The corresponding author has full control of all primary data and agrees to allow the journal to review their data if requested.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Della Pepa, R., Cerchione, C., Pugliese, N. et al. Diagnostic-driven antifungal approach in neutropenic patients at high risk for chronic disseminated candidiasis: preliminary observations on the role of 1,3-β-D-glucan antigenemia and multiphasic contrast-enhanced computed tomography. Support Care Cancer 26, 1691–1694 (2018). https://doi.org/10.1007/s00520-018-4138-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-018-4138-9

Search

Navigation