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Home parenteral nutrition improves quality of life and nutritional status in patients with cancer: a French observational multicentre study

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Abstract

Purpose

Malnutrition is a predictor of poor outcomes in patients with cancer. Little is known about the benefit of nutritional support in these patients. The purpose of this study was to assess the impact of home parenteral nutrition (HPN) on quality of life (Qol) in cancer patients.

Methods

We performed an observational prospective study to determine the impact of HPN on Qol in a population of patients with heterogeneous cancer. Physicians, patients and family members had to complete a questionnaire before HPN administration and 28 days after the course of HPN. Qol was evaluated using the self-administered questionnaire FACT-G.

Results

We included 767 patients with cancer of whom 437 ended the study. Mean patient age was 63 ± 11.4 years and 60.5 % were men. Primary gastrointestinal cancer was reported in 50 % of patients and 65.3 % were presenting metastases. Malnutrition was reported in 98.3 %. After 28 days of HPN intake, significant improvement was observed in the Qol (49.95 ± 5.82 vs. 48.35 ± 5.01 at baseline, p < 0.0001). The mean weight, serum albumin and the nutrition risk index had also improved significantly. Most patients (78 %) had perceived a positive impact of the HPN. A significant improvement in patient’s well-being was perceived also by family members and physicians.

Conclusions

Our data suggest that preventing and correcting malnutrition using HPN in patients with cancer might have a significant benefit on their well-being. Randomized controlled studies are required to confirm this finding.

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Acknowledgments

The authors would like to thank all of the study investigators at the sites participating in this trial: Dr. Sakka, Besançon; Dr. Rastgari, Créteil; Dr. Lababidi, Paris; Dr. Pacault, Paris; Dr. Botrus, Thionville; Dr. Bastit, Rouen; Dr. Guilbert, Reims; Dr. Coulon, Limoges; Dr. Hamlaoui, Besançon; Dr. Sedrati, Stains; Dr. Chuzel, Mougins; Dr. Narciso, Tours; Dr. Fabre-Guillevin, Paris; Dr. Crumbach, Freyming-Merlebach; Dr. Savinelli, Paris; Dr. Ferrier, Clermont-Ferrand; Dr. Perotin, Montpellier; Dr. Poisson-Ligeza, St Nazaire; Dr. Sellam, Créteil; Dr. Fadin, Reims; Dr. Dubroeucq, Reims; Dr. Wagner, Chambray Les Tours; Dr. Hadjadj, Marseille; Dr. Faure, Montpellier; Dr. Aldabbagh, Montpellier; Dr. Cretineau, Vandoeuvre Les Nancy; Dr. Bartholomot-Forgeot, St Nazaire; and Kalivie investigator group. The authors wish to thank Doctor Claude Yvon, Medical Affairs Director of Fresenius-Kabi, for her assistance in preparing this manuscript.

Funding

This work was supported by Fresenius-Kabi France.

Conflict of interest

All authors have declared no conflicts of interest. The authors have full control of all primary data and agree to allow the journal to review their data if requested.

Author information

Author notes

  1. S. Culine

    Present address: Department of Medical Oncology, Saint-Louis Hospital, Paris, France

Authors and Affiliations

  1. Department of Medical Oncology, Henri Mondor Hospital, Créteil, France

    S. Culine

  2. Clinical Nutrition Intensive Care Unit, Hospices Civils de Lyon, Lyon, France

    C. Chambrier

  3. Scientific Department, ClinSearch, Bagneux, France

    A. Tadmouri

  4. SIRIC Montpellier Cancer, Institut régional du Cancer de Montpellier (ICM)—Val d’Aurelle, Montpellier, France

    P. Senesse

  5. Laboratory Epsylon, EA 4556 Dynamics of Human Abilities and Health Behaviors, University of Montpellier, Montpellier, France

    P. Senesse

  6. Department of Clinical Nutrition and Gastroenterology, Institut régional du Cancer de Montpellier (ICM)—Val d’Aurelle, Montpellier, France

    P. Senesse

  7. Department of Oncology, Polyclinique de Blois, Blois, France

    P. Seys

  8. Department of Oncology, Centre Frédéric Joliot, Rouen, France

    A. Radji

  9. Department of Oncology, Radiation Oncology Centre, Bayonne, France

    M. Rotarski

  10. Department of Hepato-Gastroenterology, Hospital Antoine Béclère, Clarmart, France

    A. Balian

  11. CLCC, Centre Paul Strauss, Strasbourg, France

    P. Dufour

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  1. S. Culine
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Correspondence to S. Culine.

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Culine, S., Chambrier, C., Tadmouri, A. et al. Home parenteral nutrition improves quality of life and nutritional status in patients with cancer: a French observational multicentre study. Support Care Cancer 22, 1867–1874 (2014). https://doi.org/10.1007/s00520-014-2164-9

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  • DOI: https://doi.org/10.1007/s00520-014-2164-9

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