Abstract
Purpose
Acupuncture has been suggested as therapy for hot flashes in women with breast cancer and men with prostate cancer. In this systematic review, we sought to evaluate the long-term effects on vasomotor symptoms after the end of a defined treatment period of acupuncture in women with breast cancer and men with prostate cancer.
Methods
A literature search revealed 222 articles within the field. With defined exclusion criteria, we identified 17 studies. We also used the Jadad quality score and identified seven studies with a score of at least 3.
Results
Six of seven identified studies qualified for inclusion in an analysis that measured frequency of hot flashes weighted in relation to number of patients (n = 172). The average reduction from baseline to end of acupuncture (ranging between 5 and 12 weeks of treatment) showed 43.2 % reduction of hot flashes. At the last follow-up (mean 5.8 months, range 3–9 months) after the end of therapy, the weighted reduction from baseline was sustained at 45.6 % in the 153 of 172 patients (89 %) who were followed up.
Conclusions
Data from six prospective analyzed studies indicate at least 3-month effects after the end of acupuncture treatment for flashes in women with breast cancer and men with prostate cancer. However, larger randomized trials with long-term follow-up will be needed to confirm these preliminary findings.
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References
Avis NE, Ory M, Matthews KA et al (2003) Health-related quality of life in a multi-ethnic sample of middle-aged women: study of Women’s Health Across the Nation (SWAN). Med Care 41:1262–1276
Spetz AC, Fredrikson MG, Hammar ML (2003) Hot flashes in a male population aged 55, 65, and 75 years, living in the community of Linkoping, Sweden. Menopause 10:81–87
Spetz AC, Palmefors L, Skobe S et al (2007) Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in a Swedish elderly population. Menopause 14:999–1005
Spetz Holm AC, Fredrikson MG, Theodorsson E et al (2011) Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism. Aging Male 14:249–256
Buchholz N-P, Mattarelli G, Huber Buchholz MM (1994) Post-orchiectomy hot flashes. Eur Urol 266:120–122
Frödin T, Ålund G, Varenhorst E (1985) Measurement of skin blood-flow and water evaporation as a means of objectively assessing hot flashes after orchidectomy in patients with prostatic cancer. Prostate 7:203–208
Carpenter JS, Andrykowski MA, Cordova M et al (1998) Hot flashes in postmenopausal women treated for breast carcinoma: prevalence, severity, correlates, management, and relation to quality of life. Cancer 82:1682–1691
Harris PF, Remington PL, Trentham-Dietz A et al (2002) Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manage 23:501–509
Carpenter JS, Elam JL, Ridner SH et al (2004) Sleep, fatigue, and depressive symptoms in breast cancer survivors and matched healthy women experiencing hot flashes. Oncol Nurs Forum 31:591–598
Savard J, Davidson JR, Ivers H et al (2004) The association between nocturnal hot flashes and sleep in breast cancer survivors. J Pain Symptom Manage 27:513–522
Love RR, Cameron L, Connell B et al (1991) Symptoms associated with tamoxifen treatment in postmenopausal women. Arch Intern Med 151:1842–1847
Day R, Ganz PA, Costantino JP et al (1999) Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast and Bowel project P-1 Study. J Clin Oncol 17:2659–2669
Crandall C, Petersen L, Ganz PA et al (2004) Association of breast cancer and its therapy with menopause-related symptoms. Menopause 11:519–530
MacLennan AH, Broadbent JL, Lester S, et al. (2004) Oral oestrogen and combined oestrogen/progestagen therapy versus placebo for hot flashes. Cochrane Database Syst Rev (4):CD002978
Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333
Herrington DM, Vittinghoff E, Lin F et al (2002) Statin therapy, cardiovascular events and total mortality in the Heart and Estrogen/Progestin Replacement Study (HERS). Circulation 105:2962–2967
Beral V (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419–427
Holmberg L, Iversen OE, Rudenstam CM et al (2008) Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. J Natl Cancer Inst 100:475–482
Charig CR, Rundle JS (1989) Flashing: long-term side effect of orchiectomi in treatment of prostatic carcinoma. Urology 33:175–178
Spetz AC, Hammar M, Lindberg B et al (2001) Prospective evaluation of hot flashes during treatment with parenteral estrogen or complete androgen ablation in metastatic carcinoma of the prostate. J Urol 166:517–520
Karling P, Hammar M, Varenhorst E (1994) Prevalence and duration of vasomotor symptoms after surgical or medical castration in men with prostatic carcinoma. J Urol 152:1170–1173
Kronenberg F, Fugh-Berman A (2002) Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 137:805–813
North American Menopause Society (2004) Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause 11:11–33
Mom CH, Buijs C, Willemse PHB et al (2006) Hot flashes in breast cancer patients. Crit Rev Oncol Hematol 57:63–77
Wong VC, Lim CE, Luo X et al (2009) Current alternative and complementary therapies used in menopause. Gynecol Endocrinol 25:166–174
Albertazzi P (2007) Non-estrogenic approaches for the treatment of climacteric symptoms. Climacteric 115–120. doi:10.1080/13697130701440980
Albertazzi P (2006) Noradrenergic andsertonergic modulation to treat vasomotor symptoms. J Br Menopause Soc 12:7–11
Kenemans P, Bundred NJ, Foidart JM et al (2009) Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial. Lancet Oncol 10:135–146
Kelly CM, Juurlink DN, Gomes T et al (2010) Selective serotonin reuptake inhibitors and breastcancer mortality in women receiving tamoxifen: a population based cohort study. BMJ 340:693–701
Quella SK, Loprinzi CL, Sloan J et al (1999) Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing androgen ablation therapy for prostate cancer. J Urol 162:98–102
Roth AJ, Scher HI (1998) Sertraline relieves hot flashes secondary to medical castrations as treatment of advanced prostate cancer. Psychooncology 7:129–132
Loprinzi CL, Barton DL, Sloan JA et al (2008) Mayo clinic and north central cancer treatment group hot flash studies: a 20-year experience. Menopause 15:655–660
Loprinzi CL, Michalak JC, Quella SK et al (1994) Megestrol acetate for the prevention of hot flashes. N Engl J Med 331:347–552
Thacker H (2011) Assesing risks and benefits of non-hormonal treatments for vasomotor symptoms in perimenopausal women and postmenopausal women. J Womens Health 20:1007–1016
Irani J, Salomon L, Oba R et al (2010) Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproteroneactetate for the treatment of vasomotor hot flashes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial. Lancet Oncol 11:147–154
Frisk J (2010) Managing hot flashes in men after prostate cancer–a systematic review. Maturitas 65:15–22
Andersson S, Lundeberg T (1995) Acupuncture—from empiricism to science: functional background to acupuncture effects in pain and disease. Med Hypotheses 45:271–281
Wyon Y, Lindgren R, Lundeberg T et al (1995) Effects of acupuncture on climacteric vasomotor symptoms, quality of life and urinary excretion of neuropeptides among postmenopausal women. Menopause 2:3–12
D’Amico JF, Greendale GA, Lu JK et al (1991) Induction of hypothalamic opoid activity with transdermal estradiol administration in postmenopausal women. Fertil Steril 55:754–758
Melis GB, Paoletti AM, Gambacciani M et al (1984) Evidence that estrogens inhibit LH secretion through opioids in postmenopausal women using Naloxone. Neuroendocrinology 39:60–63
Nedstrand E, Wijma K, Wyon Y et al (2005) Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study. Climacteric 8:243–250
Cohen SM, Rosseau ME, Carey BL (2003) Can acupuncture relieve symptoms of the menopause? Holist Nurs Pract 17:295–299
Porzio G, Trapasso T, Martelli S et al (2002) Acupuncture in the treatment of menopause-related symptoms in women taking tamoxifen. Tumori 88:128–130
Nir Y, Huang MI, Schenyer R et al (2007) Acupuncture for postmenopausal hot flashes. Maturitas 56:383–395
Frisk J, Carlhäll S, Källström A-C et al (2008) Long-term follow-up of acupuncture and hormone therapy on hot flashes in women with breast cancer: a prospective, randomized, controlled multicenter trial. Climacteric 11:166–174
Hammar M, Frisk J, Grimås Ö et al (1999) Acupuncture treatment of vasomotor symptoms in men with prostatic carcinoma: a pilot study. J Urol 161:853–859
Frisk J, Spetz AC, Hjertberg H et al (2009) Two modes of acupuncture as a treatment for hot flashes in men with prostate cancer-A prospective multicenter study with long-term follow-up. Eur Urol 55:156–163
Ashmalla H, Jiang ML, Guirguis A et al (2011) Acupuncture for the alleviation of hot flashes in men treated with androgen ablation therapy. Int J Radiat Oncol Biol Phys 79:1358–1363
Baber R, Hickey M, Kwik M (2005) Therapy for menopausal symptoms during and after treatment for breast cancer: safety considerations. Drug Saf 28:1085–1100
Streitberger K, Kleinhenz J (1998) Introducing a placebo needle into acupuncture research. Lancet 352:364–365
Goddard G, Shen Y, Steele B et al (2005) A controlled trial of placebo versus real acupuncture. J Pain 6:237–242
Park J, White A, Stevinson C, Ernst E et al (2002) Validating a new non-penetrating sham acupuncture device: two randomized controlled trials. Acupunct Med 20:168–171
White P, Lewith G, Hopwood V et al (2003) The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomised, single-blind, cross-over pilot trial. Pain 106:401–409
Tsukayama H, Yamashita H, Kimura T et al (2006) Factors that influence the applicability of sham needle in acupuncture trials: two randomized, single-blind, crossover trials with acupuncture-experienced subjects. Clin J Pain 22:346–349
Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12
Deng VA, Yeung S et al (2007) Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients. J Clin Oncol 25:5584–5590
Hervik J, Mjåland O (2009) Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial. Breast Cancer Res Treat 116:311–316
Liljegren A, Gunnarsson P, Landgren BM et al (2012) Reducing vasomotor symptoms with acupuncture in breast cancer patients treated with adjuvant tamoxifen: a randomized controlled trial. Breast Cancer Res Treat 135:791–798
Tukmachi E (2000) Treatment of hot flashes in breast cancer patients with acupuncture. Acupunct Med 18:22–27
Filshie J, Bolton T, Browne D et al (2005) Acupuncture and self acupuncture for long-term treatment of vasomotor symptoms in cancer patients-audit and treatment algorithm. Acupunct Med 23:171–180
Walker G, de Valois B, Davies R et al (2007) Ear acupuncture for hot flashes—the perceptions of women with breast cancer. Complement Ther Clin Pract 14:250–257
Harding C, Harris A, Chadwick D (2008) Auricular acupuncture: a novel treatment for vasomotor symptoms associated with luteinizing-hormone releasing hormone agonist treatment for prostate cancer. BJU 103:186–190
Beer T, Benavides M, Emmons S et al (2010) Acupuncture for hot flashes in patients with prostate cancer. Urology 76:1182–1188
de Valois BA, Young TE, Robinson N et al (2010) Using traditional acupuncture for breast cancer-related hot flashes and night sweats. J Altern Complement Med 16:1047–1057
Walker E, Rodriguez A, Kohn B et al (2010) Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J Clin Oncol 28:634–640
Otte J, Carpenter J, Zhong X et al (2011) Feasibility study of acupuncture for reducing sleep disturbances and hot flashes in postmenopausal breast cancer survivors. Clin Nurse Spec 25:228–236
Bokmand S, Flyger H (2013) Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast 22:320–323
Huang W, Pach D, Napadow V et al (2012) Characterizing acupuncture stimuli using brain imaging with fMRI—a systematic review and meta-analysis of the literature. PLoS ONE 7(4):e32960. doi:10.1371/journal.pone.0032960
Freedman R (1989) Laboratory and ambulatory monitoring of menopausal hot flashes. Psychophysiology 26:573–579
Cohen FJ, Lu Y (2000) Characterization of hot flashes reported by healthy postmenopausal women receiving raloxifene or placebo during osteoporosis prevention trials. Maturitas 34:65–73
Mao JJ, Leed R, Bowman MA et al (2012) Acupuncture for hot flashes: decision making by breast cancer susvivors. J Am Board Fam Med 25:323–332
Conflict of interest
We declare no conflicts of interest. We have control of primary data regarding our own publications of original articles, but not primary data from other authors whose publications are included in this systematic review. We agree to allow the journal to review primary data regarding our own publications if requested.
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Frisk, J.W., Hammar, M.L., Ingvar, M. et al. How long do the effects of acupuncture on hot flashes persist in cancer patients?. Support Care Cancer 22, 1409–1415 (2014). https://doi.org/10.1007/s00520-014-2126-2
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DOI: https://doi.org/10.1007/s00520-014-2126-2