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Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy

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An Erratum to this article was published on 10 May 2005

Abstract

This paper uses an evidence-based approach whenever possible to formulate recommendations, emphasizing the results of controlled trials concerning the best use of antiemetic agents. We address issues of dose, schedule, and route of administration of five selective 5-HT3 antagonists. We conclude that for each of these five drugs, there is a plateau in therapeutic efficacy above which further dose escalation does not improve outcome. Furthermore, for all classes of antiemetic agents, a single dose is as effective as multiple doses or a continuous infusion. The oral route is as efficacious as the intravenous route of administration, even with chemotherapy of high emetic risk. Selective antagonists of the type 3 serotonin receptor (5-HT3) in combination with dexamethasone and aprepitant are the standard of care for the prevention of emesis following chemotherapy of high emetic risk.

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Acknowledgment

This manuscript has drawn both structure and substance from the prior MASCC Consensus Conference summary manuscripts written by Fausto Roila, David Warr, Martin J. Edelman, Edith A. Perez, Richard J. Gralla, David R. Gandara, Pieter H.M. De Mulder, and Michel Marty [18, 46].

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Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Mark G. Kris

  2. Tufts University School of Medicine, Boston, MA, USA

    Paul J. Hesketh

  3. Copenhagen University Hospital, Copenhagen, Denmark

    Jorn Herrstedt

  4. Rittenberg Oncology Consulting, Metairie, LA, USA

    Cynthia Rittenberg

  5. Walther Cancer Institute, Indianapolis, IN, USA

    Lawrence H. Einhorn

  6. Vermont Cancer Center, Shelburne, VT, USA

    Steven Grunberg

  7. University of Texas, Austin, TX, USA

    Jim Koeller

  8. Royal Adelaide Hospital Cancer Center, Adelaide, SA, Australia

    Ian Olver

  9. Linköping University, Linköping, Sweden

    Sussanne Borjeson

  10. Oncologia Medica, Perugia, Italy

    Enzo Ballatori

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  1. Mark G. Kris
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00520-005-0833-4

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Kris, M.G., Hesketh, P.J., Herrstedt, J. et al. Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy. Support Care Cancer 13, 85–96 (2005). https://doi.org/10.1007/s00520-004-0699-x

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