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Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis

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Summary

The well-known impact of ovarian endometriosis on female quality of life and the established role of lncRNA LINC01465 in ovarian cancer pathogenesis have been extensively documented; however, the relationship between LINC01465 and ovarian endometriosis is still not clear. This study seeks to explore the potential involvement of LINC01465 in the disease. The study analyzed a sample of 80 endometriosis patients and 80 healthy women. The expression of LINC01465 was measured in ectopic and eutopic endometrial tissues through RT-qPCR. The diagnostic potential of serum LINC01465 levels was evaluated using ROC curve analysis, and the patients were followed up for 3 years after treatment to monitor recurrence. The results revealed that the expression of LINC01465 was significantly lower in ectopic endometrial tissues in comparison to paired eutopic tissues for most of the patients. No correlation was found between the patient’s age or lifestyle and serum LINC01465 levels. After treatment, the serum LINC01465 level increased, and patients who experienced recurrence had significantly lower levels compared to those who did not. In conclusion, the study findings suggest that the downregulation of LINC01465 plays a role in the pathogenesis of ovarian endometriosis and may serve as a diagnostic and prognostic biomarker for the disease.

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References

  1. Králíčková M, Laganà AS, Ghezzi F, Vetvicka V. Endometriosis and risk of ovarian cancer: what do we know? Arch Gynecol Obstet. 2020;301:1–10.

    Article  PubMed  Google Scholar 

  2. Mo X, Zeng Y. The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model. Saudi J Biol Sci. 2020;27:561–6.

    Article  PubMed  Google Scholar 

  3. Streuli I, Gaitzsch H, Wenger JM, Petignat P. Endometriosis after menopause: physiopathology and management of an uncommon condition. Climacteric. 2017;20:138–43.

    Article  CAS  PubMed  Google Scholar 

  4. Falcone T, Flyckt R. Clinical Management of Endometriosis. Obstet Gynecol. 2018;131:557–71.

  5. van Barneveld E, Manders J, van Osch FHM, van Poll M, Visser L, van Hanegem N, Lim AC, Bongers MY, Leue C. Depression, Anxiety, and Correlating Factors in Endometriosis: A Systematic Review and Meta-Analysis. J Women’s Heal. 2021;31:219–30.

    Article  Google Scholar 

  6. Broi MGD, Ferriani RA, Navarro PA. Ethiopathogenic mechanisms of endometriosis-related infertility. Jbra Assist Reprod. 2019;23:273–80.

    PubMed  PubMed Central  Google Scholar 

  7. Brilhante AV, Augusto KL, Portela MC, Sucupira LC, Oliveira LA, Pouchaim AJ, Nóbrega LR, Magalhães TF, Sobreira LR. Endometriosis and Ovarian Cancer: an Integrative Review (Endometriosis and Ovarian Cancer). Asian Pac J Cancer Prev. 2017;18:11–6.

    PubMed  PubMed Central  Google Scholar 

  8. Bozdag G. Recurrence of endometriosis: risk factors, mechanisms and biomarkers. Womens Health. 2015;11:693–9.

    CAS  Google Scholar 

  9. Ceccaroni M, Bounous VE, Clarizia R, Mautone D, Mabrouk M. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reproductive Health Care. 2019;24:464–74.

    Article  Google Scholar 

  10. Maggiore ULR, Ferrero S, Mangili G, Bergamini A, Inversetti A, Giorgione V, Vigano P, Candiani M. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update. 2016;22:70–103.

    Article  Google Scholar 

  11. Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021;397:839–52.

    Article  CAS  PubMed  Google Scholar 

  12. Agarwal SK, Chapron C, Giudice LC, Laufer MR, Leyland N, Missmer SA, Singh SS, Taylor HS. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;220:354.e351–354.e312.

    Article  Google Scholar 

  13. Bai J, Wang B, Wang T, Ren W. Identification of functional lncRNas associated with ovarian endometriosis based on a ceRNA network. Front Genet. 2021;12:534054. https://doi.org/10.3389/fgene.2021.534054

  14. Cui D, Ma J, Liu Y, Lin K, Jiang X, Qu Y, Lin J, Xu K. Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis. Gene. 2018;673:140–8.

    Article  CAS  PubMed  Google Scholar 

  15. Lin K, Zhan H, Ma J, Xu K, Wu R, Zhou C, Lin J. Silencing of SRA1 regulates ER expression and attenuates the growth of stromal cells in ovarian endometriosis. Reprod Sci. 2017;24:836–43.

    Article  CAS  PubMed  Google Scholar 

  16. Malgundkar SH, Hassan NA, Al Badi H, Gupta I, Burney IA, Al Hashami Z, Al Barwani H, Al Riyami H, Al Kalbani M, Lakhtakia R, et al. Identification and validation of a novel long non-coding RNA (LINC01465) in ovarian cancer. Human Cell. 2022;36:762–74.

  17. Gabriel M, Fey V, Heinosalo T, Adhikari P, Rytkonen K, Komulainen T, Huhtinen K, Laajala TD, Siitari H, Virkki A, et al. A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions. Sci Data. 2020;7(1):284.

    Article  PubMed  PubMed Central  Google Scholar 

  18. [No authors listed]. Assisted reproductive technology in the United States: 1997 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 2000;74:641–653.

  19. Perkins A. The “silent” pain of endometriosis. Nurs Made Incred Easy. 2019;17:26–33.

  20. Koga K, Takamura M, Fujii T, Osuga Y. Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis. Fertil Steril. 2015;104:793–801.

    Article  PubMed  Google Scholar 

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Funding

We thank the financial support from the Innovative R&D project of Hunan Provincial Development and Reform Commission (No. 37).

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Authors and Affiliations

  1. Department of Gynecology, Changsha Maternal and Child Health Care Hospital, No. 416 Chengnan Dong Lu, Yuhua District, 410007, Changsha City, Hunan Province, China

    Yuying Song, Rui Huang, Xiangmei Hu, Shanshan Wu, Sihe Chen, Guangshen Liu, Mingzhi Ou & Haichun Guo

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  1. Yuying Song
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  2. Rui Huang
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  3. Xiangmei Hu
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  4. Shanshan Wu
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  5. Sihe Chen
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  6. Guangshen Liu
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  7. Mingzhi Ou
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  8. Haichun Guo
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Contributions

YS conducted this study and wrote this manuscript. RH, XH, SW, SC, GL, MO analyzed and interpreted the patient data. HG designed the study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Haichun Guo.

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Conflict of interest

Y. Song, R. Huang, X. Hu, S. Wu, S. Chen, G. Liu, M. Ou and H. Guo declare that they have no competing interests.

Ethical standards

All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Approval was obtained from the Ethics Committee of Changsha Maternal and Child Health Care Hospital. Written informed consent was obtained from all individual patients included in the study.

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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Song, Y., Huang, R., Hu, X. et al. Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis. Wien Klin Wochenschr 136, 163–168 (2024). https://doi.org/10.1007/s00508-023-02219-y

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  • DOI: https://doi.org/10.1007/s00508-023-02219-y

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