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Synergistic effects of cigarette smoking and varicocele on semen parameters in 715 patients

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Summary

Objective

To evaluate whether there is a synergistic effect of varicocele and smoking status on semen parameters.

Methods

A retrospective evaluation of 715 men attending an infertility clinic between 2001 and 2009 was carried out. The presence of a varicocele was determined by clinical examination and cigarette smoking habits were documented allowing patients to be divided into 4 groups: non-smokers (n = 369), mild smokers (n = 186, 1–10 cigarettes/day), moderate smokers (n = 129, 10–20 cigarettes/day) and heavy smokers (n = 31, over 20 cigarettes/day). Semen samples were harvested according to the World Health Organization (WHO) guidelines. Additionally, serum luteinizing hormone (LH), free testosterone and follicle stimulating hormone (FSH) levels were measured in all patients. Multivariate analysis of variance (MANOVA) was carried out and further corroborated with the non-parametric Kruskal-Wallis and Mann-Whitney U‑tests. A p-value of <0.05 was considered statistically significant.

Results

The median patient age was 30.2 years. Overall there was a statistically significant negative effect of higher varicocele grade on sperm motility and concentration (p < 0.05) and a significant negative effect of smoking status on sperm morphology and motility (very progressive, p < 0.01) as well as a significant synergistic effect of varicocele and smoking status on motility (p = 0.03). In the group of patients smoking less than 10 cigarettes per day no significant synergistic effect on semen parameters could be proven compared to patients with varicocele who did not smoke.

Conclusions

We could show a significant synergistic effect of smoking status (>10 cigarettes) in patients with varicocele on sperm morphology and motility. These findings could play an important role in counselling infertile patients presenting with varicocele and severe smoking to improve their semen quality parameters if they stop smoking. Past smoking history was not investigated.

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References

  1. WHO. Prevalence of tobacco use. A) 2015. http://apps.who.int/iris/bitstream/10665/156262/1/9789241564922_eng.pdf.

    Google Scholar 

  2. Statistik Austria. Prevalence of tobacco use. B) 2015. http://www.statistik.at/wcm/idc/idcplg?IdcService=GET_NATIV E_FILE&RevisionSelectionMethod=LatestReleased&dDoc Name=105602.

    Google Scholar 

  3. Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update. 2000;6(2):122–31.

    Article  CAS  PubMed  Google Scholar 

  4. Al-Matubsi HY, Kanaan RA, Hamdan F, Salim M, Oriquat GA, Al Hanbali OA. Smoking practices in Jordanian people and their impact on semen quality and hormonal levels among adult men. Cent Eur J Public Health. 2011;19(1):54–9.

    PubMed  Google Scholar 

  5. Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003;79(2):287–91.

    Article  PubMed  Google Scholar 

  6. Ozgur K, Isikoglu M, Seleker M, Donmez L. Semen quality of smoking and non-smoking men in infertile couples in a Turkish population. Arch Gynecol Obstet. 2005;271(2):109–12.

    Article  PubMed  Google Scholar 

  7. Redmon JB, Carey P, Pryor JL. Varicocele – the most common cause of male factor infertility? Hum Reprod Update. 2002;8(1):53–8.

    Article  PubMed  Google Scholar 

  8. Jarow JP, Sharlip ID, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, Schlegel PN, Howards SS, Nehra A, Damewood MD, et al. Best practice policies for male infertility. J Urol. 2002;167(5):2138–44.

    Article  PubMed  Google Scholar 

  9. The Practice Committee of the American Society for Reproductive Medicine. Report on varicocele and infertility. Fertil Steril. 2008;90(5 Suppl):S247–9.

    Google Scholar 

  10. Hauser R, Paz G, Botchan A, Yogev L, Yavetz H. Varicocele: effect on sperm functions. Hum Reprod Update. 2001;7(5):482–5.

    Article  CAS  PubMed  Google Scholar 

  11. Al-Ali BM, Marszalek M, Shamloul R, Pummer K, Trummer H. Clinical parameters and semen analysis in 716 Austrian patients with varicocele. Urology. 2010;75(5):1069–73.

    Article  PubMed  Google Scholar 

  12. John U, Meyer C, Hanke M, Volzke H, Schumann A. Relation between awareness of circulatory disorders and smoking in a general population health examination. BMC Public Health. 2006;6:48.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Klaiber EL, Broverman DM, Pokoly TB, Albert AJ, Howard PJ Jr., Sherer JF Jr. Interrelationships of cigarette smoking, testicular varicoceles, and seminal fluid indexes. Fertil Steril. 1987;47(3):481–6.

    Article  CAS  PubMed  Google Scholar 

  14. Collodel G, Capitani S, Iacoponi F, Federico MG, Pascarelli NA, Moretti E. Retrospective assessment of potential negative synergistic effects of varicocele and tobacco use on ultrastructural sperm morphology. Urology. 2009;74(4):794–9.

    Article  CAS  PubMed  Google Scholar 

  15. Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, et al. Varicocele is associated with impaired semen quality and reproductive hormone levels: a study of 7035 healthy young men from six European countries. Eur Urol. 2016;70(6):1019–29. doi:10.1016/j.eururo.2016.06.044.

    Article  CAS  PubMed  Google Scholar 

  16. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, Toft G, Bonde JP. Is smoking a risk factor for decreased semen quality? A cross-sectional analysis. Hum Reprod. 2007;22(1):188–96.

    Article  CAS  PubMed  Google Scholar 

  17. Sharma R, Harlev A, Agarwal A, Esteves SC. Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol. 2016;70:635–45.

    Article  PubMed  Google Scholar 

  18. Fariello RM, Pariz JR, Spaine DM, Gozzo FC, Pilau EJ, Fraietta R, Bertolla RP, Andreoni C, Cedenho AP. Effect of smoking on the functional aspects of sperm and seminal plasma protein profiles in patients with varicocele. Hum Reprod. 2012;27(11):3140–9.

    Article  CAS  PubMed  Google Scholar 

  19. Harlev A, Agarwal A, Gunes SO, Shetty A, et al. Smoking and male infertility: an evidence based review. World J Mens Health. 2015;33:143–60.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Oyeyipo IP, Raji Y, Emikpe BO, Bolarinwa AF. Effects of nicotine on sperm characteristics and fertility profile in adult male rats: a possible role of cessation. J Reprod Infertil. 2011;12:201–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Trummer H, Habermann H, Haas J, Pummer K. The impact of cigarette smoking on human semen parameters and hormones. Hum Reprod. 2002;17:1554–9.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Hanusch Krankenhaus, Heinrich Collin Straße 30, 1140, Vienna, Austria

    Badereddin Mohamad Al-Ali

  2. Department of Urology, Kaiser-Franz-Josef Spital, Kundratstraße 3, 1100, Vienna, Austria

    Klaus Eredics M.D.

Authors
  1. Badereddin Mohamad Al-Ali
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  2. Klaus Eredics M.D.
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Correspondence to Klaus Eredics M.D..

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B. Mohamad Al-Ali and K. Eredics declare that they have no competing interests.

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Mohamad Al-Ali, B., Eredics, K. Synergistic effects of cigarette smoking and varicocele on semen parameters in 715 patients. Wien Klin Wochenschr 129, 482–486 (2017). https://doi.org/10.1007/s00508-017-1199-6

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  • DOI: https://doi.org/10.1007/s00508-017-1199-6

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