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Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

Erhöhte Serum-Konzentrationen des Anti-Müller Hormons (AMH) bei Jugendlichen und jungen Erwachsenen chinesischen Patienten mit polyzystischem Ovarialsyndrom

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Zusammenfassung

ZIEL DER STUDIE: Erhebung der Serum-konzentrationen des Anti-Müller Hormons (AMH) bei adoleszenten und jungen erwachsenen chinesischen Patienten mit polycystischem Ovar Syndrom (PCOS) und Evaluierung seines diagnostischen Wertes im Rahmen des PCOS. DESIGN: Die Konzentration des AMHs wurde im Serum von 47 adoleszenten und jungen erwachsenen chinesischen Patienten mit PCOS und von 40 alters-gematchten Kontrollen gemessen. Das diagnostische Potential der AMH Konzentrationen wurde durch Erstellen von Receiver Operating Characteristics (ROC) Kurven geprüft. ERGEBNISSE: Die Serum AMH Konzentrationen waren bei den PCOS-Patienten höher als bei den Kontrollen (9,85 ± 4,93 ng/mL vs. 7,13 ± 3,02 ng/mL, P = 0,002) und korrelierten signifikant positiv mit dem mittleren Volumen des Ovars der PCOS Patienten (r = 0,319, P = 0,029). Die Fläche unter der ROC Kurve erreichte einen Wert von 0,664 (0,551–0,778, 95 % Konfidenz Intervall). Der beste Kompromiss zwischen Spezifität (70 %) und Sensitivität (61,7 %) wurde bei einem cut-off Wert von 8 ng/ml erhoben. SCHLUSSFOLGERUNGEN: Die Serum AMH Konzentrationen sind bei adoleszenten und jungen erwachsenen chinesischen Patienten mit PCOS erhöht. Die Messung der Serum AMH Konzentrationen bietet allerdings nur eine relativ schwache diagnostische Trennschärfe mit einer Sensitivität von 61,7 % und einer Spezifität von 70 % bei einem Grenzwert von 8 ng/ml.

Summary

PURPOSES: To explore the serum anti-mullerian hormone (AMH) level in adolescent and young adult Chinese patients with polycystic ovary syndrome (PCOS), and to evaluate its diagnostic value for PCOS. STUDY DESIGN: Serum AMH was measured in a cohort of 47 adolescent and young adult Chinese patients with PCOS and 40 age-matched controls. Its diagnostic potential was evaluated by Receiver Operating Characteristic (ROC) curves. RESULTS: The serum AMH level was higher in PCOS patients than in controls (9.85 ± 4.93 ng/mL vs. 7.13 ± 3.02 ng/mL, P = 0.002), and positively related to the mean ovarian volume in PCOS patients (r = 0.319, P = 0.029). The area under the ROC curve for AMH reached a value of 0.664 (0.551–0.778, 95% confidence interval). The best compromise between specificity (70%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/mL. CONCLUSIONS: Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

    Lin Li, Xiaoli Chen, Yaqin Mo, Yaxiao Chen, Meiying Wenig & Dongzi Yang

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  1. Lin Li
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  2. Xiaoli Chen
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  3. Yaqin Mo
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  4. Yaxiao Chen
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  5. Meiying Wenig
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  6. Dongzi Yang
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Correspondence to Dongzi Yang.

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Li, L., Chen, X., Mo, Y. et al. Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome. Wien Klin Wochenschr 122, 519–524 (2010). https://doi.org/10.1007/s00508-010-1426-x

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