Skip to main content
Log in

Therapie primärer chronischer Kopfschmerzen

Chronische Migräne, chronischer Kopfschmerz vom Spannungstyp und andere chronische tägliche Kopfschmerzen

Therapy of primary chronic headache

Chronic migraine, chronic tension type headache and other forms of daily chronic headache

  • Übersichten
  • Published:
Der Schmerz Aims and scope Submit manuscript

Zusammenfassung

Die Kriterien der International Headache Society (IHS) definieren 4 primäre Kopfschmerzerkrankungen, die zu täglichen Dauerkopfschmerzen führen können:

  • chronische Migräne,

  • Kopfschmerz vom Spannungstyp,

  • Hemicrania continua,

  • neu aufgetretener täglicher Kopfschmerz.

In der Praxis ist davon häufig der Kopfschmerz durch Medikamentenübergebrauch (früher Analgetikakopfschmerz) abzugrenzen. Die jetzt von der Deutschen, Österreichischen und Schweizer Kopfschmerzgesellschaft gemeinsam vorgelegte Therapieleitlinie fasst die Literatur zur Therapie dieser Kopfschmerzformen zusammen und gibt Therapieempfehlungen, die die Literaturevidenz, aber auch die Praktikabilität berücksichtigen.

Abstract

The criteria of the International Headache Society (IHS) define four different primary headache syndromes with daily chronic headaches:

  • chronic migraine,

  • episodic and chronic tension type headache,

  • hemicrania continua,

  • new daily persisting headache.

A further important differential diagnosis is medication overuse headache (previously known as analgesia headache). The German, Austrian, and Swiss headache societies now present the first joint guidelines for therapy of these headache syndromes. The current literature was reviewed and a summary is presented. The therapy recommendations do not only include the scientific evidence but also the practical relevance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Pfaffenrath V, Brune K, Diener HC et al. (1998) Die Behandlung des Kopfschmerzes vom Spannungstyp. Therapieempfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft. Nervenheilkunde 17: 91–100

    Google Scholar 

  2. Diener HC (2005) Leitlinien für Diagnostik und Therapie in der Neurologie, 3. Aufl. Thieme, Stuttgart

  3. Olesen J, Bousser M-G, Diener H et al. (2004) The international classification of headache disorders, 2nd edn. Cephalalgia 24 [suppl 1]: 1–160

  4. Diener HC, Limmroth V (2004) Medication-overuse headache: a worldwide problem. Lancet Neurol 8: 475–483

    Google Scholar 

  5. May A, Straube A, Peikert A, Diener H (2005) Diagnostik und apparative Zusatzuntersuchungen bei Kopfschmerzen. In: Diener H (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. Thieme, Stuttgart, S 476–479

  6. Silberstein SD, Lipton RB, Sliwinski M (1996) Classification of daily and near-daily headaches. Field trial of revised IHS criteria. Neurology 47: 871–875

    PubMed  CAS  Google Scholar 

  7. Silberstein SD, Lipton RB (2000) Chronic daily headache. Curr Opin Neurol 13: 277–283

    PubMed  CAS  Google Scholar 

  8. Mitsikostas DD, Tsaklakidou D, Athanasiadis N, Thomas A (1996) The prevalence of headache in Greece: correlations to latitude and climatological factors. Headache 36: 168–173

    PubMed  CAS  Google Scholar 

  9. Pascual J, Colas R, Castillo J (2001) Epidemiology of chronic daily headache. Curr Pain Headache Rep 5: 529–536

    PubMed  CAS  Google Scholar 

  10. Colas R, Munoz P, Temprano R et al. (2004) Chronic daily headache with analgesic overuse: epidemiology and impact on quality of life. Neurology 62: 1338–1342

    PubMed  CAS  Google Scholar 

  11. Láinez MJA, Monzón MJ (2001) Chronic daily headache. Curr Neurol Neurosci Rep 1: 118–124

    PubMed  Google Scholar 

  12. Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106: 81–89

    PubMed  CAS  Google Scholar 

  13. Zwart JA, Dyb G, Hagen K et al. (2003) Analgesic use: a predictor of chronic pain and medication overuse headache: the Head-HUNT Study. Neurology 61: 160–164

    PubMed  Google Scholar 

  14. Zwart JA, Dyb G, Hagen K et al. (2004) Analgesic overuse among subjects with headache, neck, and low back pain. Neurology 62: 1540–1544

    PubMed  Google Scholar 

  15. Katsarava Z, Schneeweiss S, Kurth T et al. (2004) Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 62: 788–790

    PubMed  CAS  Google Scholar 

  16. Wang SJ, Fuh JL, Lu SR, Juang KD (2006) Chronic daily headache in adolescents: prevalence, impact, and medication overuse. Neurology 66: 193–197

    PubMed  Google Scholar 

  17. Dyb G, Holmen TL, Zwart JA (2006) Analgesic overuse among adolescents with headache: the Head-HUNT-Youth Study. Neurology 66: 198–220

    PubMed  Google Scholar 

  18. Juang K-D, Wang S-J, Fuh J-L et al. (2000) Comorbidity of depressive and anxiety disorders in chronic daily headache and its subtypes. Headache 40: 818–823

    PubMed  CAS  Google Scholar 

  19. Radat F, Swendsen J (2005) Psychiatric comorbidity in migraine: a review. Cephalalgia 25: 165–178

    PubMed  CAS  Google Scholar 

  20. Olesen J, Bousser MG, Diener HC et al. for the Headache Classification Committee (2006) New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 26: 742–746

    PubMed  CAS  Google Scholar 

  21. De Tommaso M, Losito L, Difruscolo O et al. (2005) Changes in cortical processing of pain in chronic migraine. Headache 45: 1208–1218

    Google Scholar 

  22. Aurora SK, Barrodale P, Chronicle EP, Mulleners WM (2005) Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness. Headache 45: 546–552

    PubMed  Google Scholar 

  23. Diener HC, Limmroth V, Fritsche G et al. (2005) Therapie der Migräneattacke und Migräneprophylaxe. In: In: Diener H (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie, 3. Aufl. Thieme, Stuttgart

  24. Dowson AJ, Dodick DW, Limmroth V (2005) Medication overuse headache in patients with primary headache disorders: epidemiology, management and pathogenesis. CNS Drugs 19: 483–497

    PubMed  Google Scholar 

  25. Silvestrini M, Bartolini M, Coccia M et al. (2003) Topiramate in the treatment of chronic migraine. Cephalalgia 23: 820–824

    PubMed  CAS  Google Scholar 

  26. Rothrock JF, Parada VA, Drinkard R et al. (2005) Predictors of a negative response to topiramate therapy in patients with chronic migraine. Headache 45: 932–935

    PubMed  Google Scholar 

  27. Mathew NT, Kailasam J, Meadors L (2002) Prophylaxis of migraine, transformed migraine, and cluster headache with topiramate. Headache 42: 796–803

    PubMed  Google Scholar 

  28. Bartolini M, Silvestrini M, Taffi R et al. (2005) Efficacy of topiramate and valproate in chronic migraine. Clin Neuropharmacol 28: 277–279

    PubMed  CAS  Google Scholar 

  29. Diener H, Bussone G, Van Oene J et al. TOPMAT-MIG-201 (TOP-CHROME) Study Group (2006) Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia 27: 814–823

    Google Scholar 

  30. Rothrock J (1999) Management of chronic daily headache utilizing a uniform treatment pathway. Headache 39: 650–653

    PubMed  CAS  Google Scholar 

  31. Freitag FG, Diamond S, Diamond ML, Urban GJ (2001) Divalproex in the long-term treatment of chronic daily headache. Headache 41: 271–278

    PubMed  CAS  Google Scholar 

  32. Tomkins GE, Jackson JL, O’Malley PG et al. (2001) Treatment of chronic headache with antidepressants: a meta-analysis. Am J Med 111: 54–63

    PubMed  CAS  Google Scholar 

  33. Matharu MS, Bartsch T, Ward N et al. (2004) Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 127: 220–230

    PubMed  Google Scholar 

  34. Mauskop A (2005) Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia 25: 82–86

    PubMed  CAS  Google Scholar 

  35. Mathew NT, Frishberg BM, Gawel M et al. BOTOX CDH Study Group (2005) Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: a randomized, double-blind, placebo-controlled trial. Headache 45: 293–307

    PubMed  Google Scholar 

  36. Dodick DW, Mauskop A, Elkind AH et al. BOTOX CDH Study Group (2005) Botulinum toxin type A for the prophylaxis of chronic daily headache: subgroup analysis of patients not receiving other prophylactic medications: a randomized double-blind, placebo-controlled study. Headache 45: 315–324

    PubMed  Google Scholar 

  37. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C et al. (2005) Preventive non-pharmacological treatment and nitric oxide in chronic migraine. J Headache Pain 6: 341–342

    PubMed  CAS  Google Scholar 

  38. Penzien DB, Rains JC, Lipchik GL et al. (2005) Future directions in behavioural headache research: applications for an evolving health care environment. Headache 45: 526–534

    PubMed  Google Scholar 

  39. Karli N, Zarifoglu M, Calisir N, Akgoz S (2005) Comparison of pre-headache phases and trigger factors of migraine and episodic tension-type headache: do they share similar clinical pathophysiology? Cephalalgia 25: 444–451

    PubMed  CAS  Google Scholar 

  40. Ulrich V, Gervil M, Olesen J (2004) The relative influence of environment and genes in episodic tension-type headache. Neurology 62: 2065–2068

    PubMed  Google Scholar 

  41. Jensen R (1999) Pathophysiological mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia 19: 602–621

    PubMed  CAS  Google Scholar 

  42. Christensen MB, Bendtsen L, Ashina M, Jensen R (2005) Experimental induction of muscle tenderness and headache in tension-type headache patients. Cephalalgia 25: 1061–1067

    PubMed  CAS  Google Scholar 

  43. Ashina S, Bendtsen L, Ashina M (2005) Pathophysiology of tension-type headache. Curr Pain Headache Rep 9: 415–422

    PubMed  Google Scholar 

  44. Holzhammer J, Wöber C (2006) Alimentäre Triggerfaktoren bei Migräne und Kopfschmerz vom Spannungstyp. Schmerz 20: 151–159

    PubMed  CAS  Google Scholar 

  45. Martínez-Martín P, Raffaelli E, Titus F et al. (2001) Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study. Cephalalgia 21: 604–610

    PubMed  Google Scholar 

  46. Haag G, Evers S, May A et al. (2004) Selbstmedikation bei Migräne und Kopfscherzen vom Spannungstyp. Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerz-Gesellschaft (DMKG). Nervenheilkunde 23: 415–430

    Google Scholar 

  47. Cerbo R, Barbanti P, Fabbrini G et al. (1998) Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications. Headache 38: 453–457

    PubMed  CAS  Google Scholar 

  48. White AR, Resch KL, Chan JC et al. (2000) Acupuncture for episodic tension-type headache: a multicentre randomized controlled trial. Cephalalgia 20: 632–637

    PubMed  CAS  Google Scholar 

  49. Bronfort G, Nilsson N, Haas M et al. (2004) Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database Syst Rev 3: CD001878

    PubMed  Google Scholar 

  50. Verhagen AP, Damen L, Berger MY et al. (2005) Conservative treatments of children with episodic tension-type headache. A systematic review. J Neurol 252: 1147–1154

    PubMed  Google Scholar 

  51. Russell MB, Ostergaard S, Bendtsen L, Olesen J (1999) Familial occurrence of chronic tension-type headache. Cephalalgia 19: 207–210

    PubMed  CAS  Google Scholar 

  52. Spierings ELH, Ranke AH, Schroevers M, Honkoop PC (2000) Chronic daily headache: a time perspective. Headache 40: 306–310

    PubMed  CAS  Google Scholar 

  53. Breslau N, Schultz LR, Stewart WF et al. (2000) Headache and major depression. Is the association specific to migraine? Neurology 54: 308–313

    PubMed  CAS  Google Scholar 

  54. Bendtsen L (2000) Central sensitization in tension-type headache-possible pathophysiological mechanisms. Cephalalgia 20: 486–508

    PubMed  CAS  Google Scholar 

  55. Ashina M, Lassen LH, Bendtsen L et al. (1999) Effect of inhibition of nitiric oxide synthase on chronic tension-type headache: a randomized crossover trial. Lancet 353: 287–289

    PubMed  CAS  Google Scholar 

  56. Jensen R, Olesen J (2000) Tension-type headache: an update on mechanisms and treatment. Curr Opin Neurol 13: 285–289

    PubMed  CAS  Google Scholar 

  57. Ashina M (2004) Neurobiology of chronic tension-type headache. Cephalalgia 24: 161–172

    PubMed  CAS  Google Scholar 

  58. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML et al. (2006) Myofascial trigger points and their relationship to headache clinical parameters in chronic tension-type headache. Headache 46: 1264–1272

    PubMed  Google Scholar 

  59. Makowska A, Panfil C, Ellrich J (2005) Nerve growth factor injection into semispinal neck muscle evokes sustained facilitation of the jaw-opening reflex in anesthetized mice – possible implications for tension-type headache. Exp Neurol 191: 301–309

    PubMed  CAS  Google Scholar 

  60. Makowska A, Panfil C, Ellrich J (2005) Long-term potentiation of orofacial sensorimotor processing by noxious input from the semispinal neck muscle in mice. Cephalalgia 25: 109–116

    PubMed  CAS  Google Scholar 

  61. Panfil C, Makowska A, Ellrich J (2006) Brainstem and cervical spinal cord fos immunoreactivity evoked by nerve growth factor injection into neck muscles in mice. Cephalalgia 26: 128–135

    PubMed  CAS  Google Scholar 

  62. Schmidt-Wilcke T, Leinisch E, Straube A et al. (2005) Gray matter decrease in patients with chronic tension type headache. Neurology 65: 1483–1486

    PubMed  CAS  Google Scholar 

  63. Hannerz J, Jogestrand T (1998) Is chronic tension-type headache a vascular headache? The relation between chronic tension-type headache and cranial hemodynamics. Headache 38: 668–675

    PubMed  CAS  Google Scholar 

  64. Hannerz J, Schnell PO, Larsson S, Jacobsson H (2004) Blood pool scintigraphy of the skull in relation to head-down tilt provocation in patients with chronic tension-type headache and controls. Headache 44: 223–229

    PubMed  Google Scholar 

  65. Silberstein SD, Olesen J, Bousser MG et al. International Headache Society (2005) The international classification of headache disorders, 2nd edn. (ICHD-II-)revision of criteria for 8.2 medication-overuse headache. Cephalalgia 25: 460–465

    PubMed  CAS  Google Scholar 

  66. Holroyd KA, O’Donnell FJ, Stensland M et al. (2001) Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy and their combination. JAMA 285: 2208–2215

    PubMed  CAS  Google Scholar 

  67. Redillas C, Solomon S (2000) Prophylactic pharmacological treatment of chronic daily headache. Headache 40: 83–102

    PubMed  CAS  Google Scholar 

  68. Ashina S, Bendtsen L, Jensen R (2004) Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition. Pain 108: 108–114

    PubMed  CAS  Google Scholar 

  69. Pfaffenrath V, Diener HC, Isler H et al. (1994) Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study. Cephalalgia 14: 149–155

    PubMed  CAS  Google Scholar 

  70. Holroyd KA, Labus JS, O’Donnell FJ, Cordingley GE (2003)Treating chronic tension-type headache not responding to amitriptyline hydrochloride with paroxetine hydrochloride: a pilot evaluation. Headache 43: 999–1004

    PubMed  Google Scholar 

  71. Moja PL, Cusi C, Sterzi RR, Canepari C (2005) Selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headaches. Cochrane Database Syst Rev 3: CD002919

    PubMed  Google Scholar 

  72. Fogelholm R, Murros K (1992) Tizanidine in chronic tension-type headache: a placebo controlled, double-blind cross over study. Headache 32: 509–513

    PubMed  CAS  Google Scholar 

  73. Murros K, Kataja M, Hedman C et al. (2000) Modified-release formulation of tizanidine in chronic tension-type headache. Headache 40: 633–637

    PubMed  CAS  Google Scholar 

  74. Vernon H, McDermaid CS, Hagino C (1999) Systematic review of randomized clinical trials of complementary/alternative therapies in the treatment of tension-type and cervicogenic headache. Complement Ther Med 7: 142–155

    PubMed  CAS  Google Scholar 

  75. Bendtsen L, Jensen R (2004) Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 62: 1706–1711

    PubMed  CAS  Google Scholar 

  76. Langemark M, Olesen J (1994) Sulpiride and paroxetine in the treatment of chronic tension-type headache. An explanatory double-blind trial. Headache 34: 20–24

    PubMed  CAS  Google Scholar 

  77. Spira PJ, Beran RG, Australian Gabapentin Chronic Daily Headache Group (2003) Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study. Neurology 61: 1753–1759

    PubMed  CAS  Google Scholar 

  78. Lampl C, Marecek S, May A, Bendtsen L (2006) A prospective, open-label, long-term study of the efficacy and tolerability of topiramate in the prophylaxis of chronic tension-type headache. Cephalalgia 26: 1203–1208

    PubMed  CAS  Google Scholar 

  79. Robbins L (1999) Long-acting opioids for severe chronic daily headache. Headache Q 10: 135–139

    Google Scholar 

  80. Saper JR, Lake AE 3rd, Hamel RL et al. (2004) Daily scheduled opioids for intractable head pain: long-term observations of a treatment program. Neurology 62: 1687–1694

    PubMed  CAS  Google Scholar 

  81. Bettucci D, Testa L, Calzoni S et al. (2006) Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life. J Headache Pain 7: 34–36

    PubMed  CAS  Google Scholar 

  82. Rampello L, Alvano A, Chiechio S et al. (2004) Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache. Neuropsychobiology 50: 322–328

    PubMed  CAS  Google Scholar 

  83. Bernstein DA, Borkovec TD (1975) Entspannungstraining. Handbuch der Progressiven Muskelrelaxation. Pfeiffer, München

  84. Larsson B, Andrasik F (2002) Relaxation treatment of recurrent headaches in children and adolescents. In: Guidetti V, Russell G, Sillanpää M, Winner P (eds) Headaches and migraine in childhood and adolescence. Dunitz, London, UK, pp 307–316

  85. Andrasik F, Walch SE (2003) Headaches. In: Nezu AM, Nezu CM, Geller PA (eds) Handbook of psychology, vol 9. Wiley, New York, pp 245–266

  86. Harpole LH, Samsa GP, Jurgelski AE et al. (2003) Headache management program improves outcome for chronic headache. Headache 43: 715–723

    PubMed  Google Scholar 

  87. Andrasik F, Lords AO, Biofeedback (2004) Mosbys complementary & alternative medicine: a research-based approach, 2nd edn. Mosby, St. Louis

  88. Sarafino EP, Goehring P (2000) Age comparisons in acquiring biofeedback control and success in reducing headache pain. Ann Behav Med 22: 10–16

    PubMed  CAS  Google Scholar 

  89. Penzien DB, Rains JC, Andrasik F (2002) Behavioral management of recurrent headache: three decades of experience and empiricism. Appl Psychophysiol Biofeedback 27: 163–181

    PubMed  Google Scholar 

  90. Torelli P, Jensen R, Olesen J (2004) Physiotherapy for tension-type headache: a controlled study. Cephalalgia 24: 29–36

    PubMed  CAS  Google Scholar 

  91. Evers S, Rahmann A, Vollmer-Haase J, Husstedt IW (2002) Treatment of headache with botulinum toxin A – a review according to evidence-based medicine criteria. Cephalalgia 22: 699–710

    PubMed  CAS  Google Scholar 

  92. Schulte-Mattler WJ, Krack P, BoNTTH Study Group (2004) Treatment of chronic tension-type headache with botulinum toxin A: a randomized, double-blind, placebo-controlled multicenter study. Pain 109: 110–114

    PubMed  CAS  Google Scholar 

  93. Vickers AJ, Rees RW, Zollman CE et al. (2004) Acupuncture for chronic headache in primary care: large, pragmatic, randomized trial. BMJ 328: 744

    PubMed  Google Scholar 

  94. Melchart D, Streng A, Hoppe A et al. (2005) Acupuncture in patients with tension-type headache: randomized controlled trial. BMJ 331: 376–382

    PubMed  Google Scholar 

  95. Coeytaux RR, Kaufman JS, Kaptchuk TJ et al. (2005) A randomized, controlled trial of acupuncture for chronic daily headache. Headache 45: 1113–1123

    PubMed  Google Scholar 

  96. Evers S, Pothmann R, Überall M et al. (2001) Therapie idiopathischer Kopfschmerzen im Kindesalter. Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft. Nervenheilkunde 20: 306–315

    Google Scholar 

  97. Peres MF, Silberstein SD, Nahmias S et al. (2000) Hemicrania continua is not that rare. Neurology 57: 948–951

    Google Scholar 

  98. Newman LC, Spears RC, Lay CL (2004) Hemicrania continua: a third case in which attacks alternate sides. Headache 44: 821–823

    PubMed  Google Scholar 

  99. Matharu MS, Bradbury P, Swash M (2006) Hemicrania continua: side alternation and response to topiramate. Cephalalgia 26: 341–344

    PubMed  CAS  Google Scholar 

  100. Sjaastad O, Stovner LJ, Stolt Nielsen A et al. (1995) CPH and hemicrania continua: requirements of high indomethacin dosages – an ominous sign? Headache 35: 363–367

    PubMed  CAS  Google Scholar 

  101. Pareja JA, Vincent M, Antonaci F, Sjaastad O (2001) Hemicrania continua: diagnostic criteria and nosologic status. Cephalalgia 21: 874–877

    PubMed  CAS  Google Scholar 

  102. Hannerz J (2000) Chronic bilateral headache responding to indomethazin. Headache 40: 840–843

    PubMed  CAS  Google Scholar 

  103. Lay CL, Newman LC (1999) Posttraumatic hemicrania continua. Headache 39: 275–279

    PubMed  CAS  Google Scholar 

  104. Levy MJ, Matharu MS, Meeran K et al. (2005) The clinical characteristics of headache in patients with pituitary tumours. Brain 128: 1921–1930

    PubMed  CAS  Google Scholar 

  105. Vikelis M, Xifaras M, Magoufis G et al. (2005) Headache attributed to unruptured saccular aneurysm, mimicking hemicrania continua. J Headache Pain 6: 156–158

    PubMed  Google Scholar 

  106. Rogalewski A, Evers S (2005) Symptomatic hemicrania continua after internal carotid artery dissection. Headache 45: 167–169

    PubMed  Google Scholar 

  107. Matharu MS, Cohen AS, McGonigle DJ et al. (2004) Posterior hypothalamic and brainstem activation in hemicrania continua. Headache 44: 747–746

    PubMed  Google Scholar 

  108. Spears RC (2006) Hemicrania continua: a case in which a patient experienced complete relief on melatonin. Headache 46: 524–527

    PubMed  Google Scholar 

  109. Rajabally YA, Jacob S (2005) Hemicrania continua responsive to verapamil. Headache 45: 1082–1083

    PubMed  Google Scholar 

  110. Lanteri-Minet M, Auray JP, El Hasnaoui A et al. (2003) Prevalence and description of chronic daily headache in the general population in France. Pain 102: 143–149

    PubMed  Google Scholar 

  111. Chakravarty A (2003) Chronic daily headaches: clinical profile in Indian patients. Cephalalgia 23: 348–353

    PubMed  CAS  Google Scholar 

  112. Li D, Rozen TD (2002) The clinical characterization of new daily persistent headache. Cephalalgia 22: 66–69

    PubMed  CAS  Google Scholar 

  113. Silberstein SD, Lipton RB, Solomon S, Mathew NT (1994) Classification of daily and near daily headaches: proposed revisions to the IHS-criteria. Headache 34: 1–7

    Google Scholar 

  114. Vanast WJ, Diaz-Mitoma F, Tyrrell DL (1987) Hypothesis: chronic benign daily headache is an immune disorder with a viral trigger. Headache 27: 138–142

    PubMed  CAS  Google Scholar 

  115. Diaz-Mitoma F, Vanast WJ, Tyrrell DL (1987) Increased frequency of Epstein-Barr virus excretion in patients with new daily persistent headaches. Lancet 1: 411–415

    PubMed  CAS  Google Scholar 

  116. Hamada T, Ohshima K, Ide Y et al. (1991) A case of new daily persistent headache with elevated antibodies to Epstein-Barr virus. Jpn J Med 30: 161–163

    PubMed  CAS  Google Scholar 

  117. Mack KJ (2004) What incites new daily persistent headache in children? Pediatr Neurol 31: 122–125

    PubMed  Google Scholar 

  118. Goadsby PJ, Boes C (2002) New daily persistent headache. J Neurol Neurosurg Psychiatry 72 [suppl 2]: ii6–ii9

  119. Rozen TD (2003) New daily persistent headache. Curr Pain Headache Rep 7: 218–223

    PubMed  Google Scholar 

  120. Evans RW, Rozen TD (2001) Etiology and treatment of new daily persistent headache. Headache 41: 830–832

    PubMed  CAS  Google Scholar 

  121. Evans RW (2003) New daily persistent headache. Curr Pain Headache Rep 7: 3003–3307

    Google Scholar 

  122. Vanast WJ (1986) New daily persistent headaches definition of a benign syndrome. Headache 26: 318

    Google Scholar 

  123. Paemeleire K, Bahra A, Evers S et al. (2006) Medication-overuse headache in patients with cluster headache. Neurology 67: 109–113

    PubMed  CAS  Google Scholar 

  124. Fuh JL, Wang SJ, Lu SR, Juang KD (2005) Does medication overuse headache represent a behavior of dependence? Pain 119: 49–55

    PubMed  Google Scholar 

  125. Radat F, Creach C, Swendsen JD et al. (2005) Psychiatric comorbidity in the evolution from migraine to medication overuse headache. Cephalalgia 25: 519–522

    PubMed  CAS  Google Scholar 

  126. Limmroth V, Katsarava Z, Fritsche G et al. (2002) Features of medication overuse headache following overuse of different acute headache drugs. Neurology 59: 1011–1014

    PubMed  CAS  Google Scholar 

  127. Fumal A, Laureys S, Di Clemente L et al. (2006) Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain 129: 543–550

    PubMed  Google Scholar 

  128. Ayzenberg I, Obermann M, Nyhuis P et al. (2006) Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia 26: 1106–1114

    PubMed  CAS  Google Scholar 

  129. Relja G, Granato A, Bratina A et al. (2006) Outcome of medication overuse headache after abrupt in-patient withdrawal. Cephalalgia 26: 589–595

    PubMed  CAS  Google Scholar 

  130. Katsarava Z, Fritsche G, Muessig M et al. (2001) Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology 57: 1694–1698

    PubMed  CAS  Google Scholar 

  131. Coskun O, Ucler S, Cavdar L, Inan LE (2007) Effect of valproic acid on withdrawal therapy in patients with overuse of chronic daily headache medications. J Clin Neurosci 14: 334–339

    PubMed  CAS  Google Scholar 

  132. Zeeberg P, Olesen J, Jensen R (2006) Probable medication-overuse headache. Neurology 66: 1–5

    Google Scholar 

  133. Descombes S, Brefel-Courbon C, Thalamas C et al. (2001) Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. Headache 41: 178–182

    PubMed  CAS  Google Scholar 

  134. Katsarava Z, Limmroth V, Finke M et al. (2003) Rates and predictors for relapse in medication overuse headache: a 1-year prospective study. Neurology 60: 1682–1683

    PubMed  CAS  Google Scholar 

  135. Suhr B, Evers S, Bauer B et al. (1999) Drug-induced headache: long-term results of stationary versus ambulatory withdrawal therapy. Cephalalgia 19: 44–49

    PubMed  CAS  Google Scholar 

  136. Fritsche G, Eberl A, Katsarava Z et al. (2001) Drug-induced headache: long-term follow-up of withdrawal therapy and persistence of drug misuse. Eur Neurol 45: 229–235

    PubMed  CAS  Google Scholar 

  137. Grazzi L, Andrasik F, D’Amico D et al. (2002) Behavioral and pharmacologic treatment of transformed migraine with analgesic overuse: outcome at 3 years. Headache 42: 483–490

    PubMed  Google Scholar 

  138. Krymchantowski AV, Moreira PF (2003) Out-patient detoxification in chronic migraine: comparison of strategies. Cephalalgia 23: 982–993

    PubMed  CAS  Google Scholar 

Download references

Interessenkonflikt

A. Straube hat von folgenden Firmen in den letzten 2 Jahren finanzielle Unterstützung für Forschungsprojekte oder Honorare für Vorträge erhalten: GlaxoSmithKline, MSD, Pfizer, JanssenCilag, Almirall, Berlin Chemie, Novartis, Pharm Allergan.

A. May hat von den folgenden Firmen in den letzten 2 Jahren finanzielle Unterstützung für Forschungsprojekte oder Honorare für Vorträge erhalten: GlaxoSmithKline, BayerVital, Astra-Zeneca, MSD, Berlin Chemie, Pfizer, Almirall, Bristol-Meyers-Squibb, JanssenCilag.

P. Kropp, Z. Katsarava, G. Haag, B. Lampl, P.S. Sándor geben an, dass kein Interessenkonflikt besteht.

H.-C. Diener hat von folgenden Firmen finanzielle Unterstützung für Forschungsprojekte oder Honorare für Vorträge/Beratung erhalten: Addex Pharma, Allergan, Almirall, AstraZeneca, Bayer Vital, Berlin Chemie, CoLucid, Böhringer Ingelheim, Bristol-Myers Squibb, GlaxoSmithKline, Grünenthal, Janssen-Cilag, Lilly, La Roche, 3 M Medica, MSD, Novartis, Johnson & Johnson, Pierre Fabre, Pfizer, Schaper and Brümmer, SanofiAventis, Weber & Weber.

S. Evers hat von folgenden Firmen in den letzten 2 Jahren finanzielle Unterstützung für Forschungsprojekte oder Honorare für Vorträge oder Beratungen erhalten: Allergan, Almirall, AstraZeneca, BerlinChemie/Menarini, Boehringer-Ingelheim, Eisai, GSK, Ipsen, Janssen-Cilag, Merz, MSD, NMT, Novartis, Pfizer, Sanofi-Synthelabo, UCB Pharma, Janssen Cilag (Johnson & Johnson), Merz, MSD, Pfizer, Novartis, Pharm Allergan.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Straube.

Additional information

Erstellungsdatum 01.12.2006, nötige Überarbeitung und Aktualisierung: 2009.

Diese Leitlinie entstand in Kooperation der Deutschen, Österreichischen und Schweizerischen Fachgesellschaften für Kopfschmerzen sowie der Deutschen Gesellschaft für Neurologie (DGN).

Sie entstand ohne Einflussnahme oder Unterstützung durch die pharmazeutische Industrie.

Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft (DMKG) in Zusammenarbeit mit der Österreichischen Kopfschmerzgesellschaft und der Schweizerischen Kopfwehgesellschaft.

Erstveröffentlichung: Straube A, May A, Kropp P et al. (2007) Therapie primärer chronischer Kopfschmerzen: Chronische Migräne, chronische Kopfschmerzen vom Spannungstyp und andere chronische tägliche Kopfschmerzen. Nervenheilkunde 3: 186–199. Mit Genehmigung des Schattauer-Verlags.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Straube, A., May, A., Kropp, P. et al. Therapie primärer chronischer Kopfschmerzen. Schmerz 22, 531–543 (2008). https://doi.org/10.1007/s00482-008-0645-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00482-008-0645-9

Schlüsselwörter

Keywords

Navigation