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Microalbuminuria among HIV-infected antiretroviral therapy-naive children in the Democratic Republic of Congo

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Abstract

Background

To determine the prevalence of microalbuminuria and associated factors among Congolese human immunodeficiency virus (HIV)-infected children.

Methods

This was a cross-sectional study in which 77 HIV-infected antiretroviral therapy-naive children and 89 uninfected controls were enrolled. Microalbuminuria was assessed using the immune-turbidimetry method, and associated factors were studied by logistic regression.

Results/Conclusion

The prevalence of microalbuminuria was 18% in the HIV-infected children and 2% in the HIV-uninfected children. No common determinants of proteinuria were significantly associated with microalbuminuria.

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Acknowledgments

The authors thank all of the children, guardians and parents who participated in this study. We also thank all of our colleagues who were involved in the collection of samples and all of the nurses and technicians of the six hospitals for their continuing support.

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Authors and Affiliations

  1. Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, P.O. Box 123, Kinshasa, Democratic Republic of Congo

    Pépé M. Ekulu & Michel N. Aloni

  2. Service de Pédiatrie, Centre de référence Maladies Rénales Rares du Sud-Ouest, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

    Jérôme Harambat

  3. Division of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo

    Jean Robert R. Makulo, François B. Lepira, Ernest K. Sumaili & Nazaire M. Nseka

  4. Department of Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo

    Eric M. Mafuta

  5. Service de Néphrologie et Rhumatologie Pédiatrique, Centre de référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France

    Pierre Cochat

Authors
  1. Pépé M. Ekulu
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  2. Michel N. Aloni
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  3. Jérôme Harambat
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  4. Jean Robert R. Makulo
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  5. François B. Lepira
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  6. Ernest K. Sumaili
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  7. Eric M. Mafuta
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  8. Pierre Cochat
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  9. Nazaire M. Nseka
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Corresponding author

Correspondence to Pépé M. Ekulu.

Ethics declarations

Ethical Approval

Written informed consent was obtained from all of the parents of all participants before the study was conducted. The study was approved by the Ethics Committee of the University of Kinshasa.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Source of support

None.

Disclosure of funding received for this work

none

Authors’ contributions

PME, MNA, FBL, and NMN conceived the study; PME, MNA, FBL, RMN, EMM and NMN designed the study protocol; PME, MNA carried out the clinical assessment; EMM, PME, ESK, JH, PC, JRRM and MNA analyzed and interpreted the data. PME, PC, ESK, JRRM and MNA drafted the manuscript; PC, JH, ESK, JRRM, FBL and MNA critically revised the manuscript for intellectual content. All authors read and approved the final manuscript. PME, MNA and NMN are guarantors of the paper.

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Cite this article

Ekulu, P.M., Aloni, M.N., Harambat, J. et al. Microalbuminuria among HIV-infected antiretroviral therapy-naive children in the Democratic Republic of Congo. Pediatr Nephrol 31, 769–772 (2016). https://doi.org/10.1007/s00467-015-3277-1

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  • DOI: https://doi.org/10.1007/s00467-015-3277-1

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