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Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency

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Abstract

Background

Oxidative stress has been reported to play an important role in children with primary nephrotic syndrome (PNS). However, the results of previous studies are controversial.

Methods

Forty children with steroid-sensitive nephrotic syndrome (SSNS) and 20 age- and sex-matched healthy controls were enrolled. Patients were followed-up for 12-18 months and divided into three subgroups: frequent relapse (n = 10), non-frequent relapse (n = 12), and non-relapse (n = 18). The plasma levels of advanced oxidation protein products (AOPP), malondialdehyde (MDA), and superoxide dismutase (SOD) were tested in controls and patient group at first presentation and after 4 weeks of steroid treatment.

Results

Patients had higher AOPP and MDA levels but lower SOD compared with controls. AOPP levels were significantly higher in the frequent relapse subgroup compared with the non-frequent relapse and non-relapse subgroups, respectively. No significant differences were found in the plasma levels of MDA and SOD among the three subgroups. AOPP >87.55 μmol/l before steroid treatment and AOPP >78.5 μmol/l after 4-week steroid treatment were positively correlated with the relapse frequency in patients with SSNS.

Conclusions

Children with SSNS have oxidative stress. The plasma levels of AOPP before and after 4-week steroid treatment may predict whether patients with SSNS will relapse frequently.

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Acknowledgments

This study was supported by the Science and Technology Program of Guangzhou, China grant (No 2014A020212140) and the Traditional Chinese Medicine Bureau of Guangdong Province grant (No 20151161).

Conflict of interest

The authors have no conflict of interest to declare.

Ethical disclosure

The study protocol was approved by the Affiliated Hospital of Sun Yat-sen University Ethics Committee. Informed consent was obtained from patients aged over 8 and the parents of all patients.

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Authors and Affiliations

  1. Department of Pediatrics, Eastern District of the First Affiliated Hospital, Sun Yet-sen University, NO. 183, Huangpu East Road, Huangpu District, Guangzhou, 510070, China

    Aiwen Fan & Huizhen Tan

  2. Department of Pediatrics, the First Affiliated Hospital, Sun Yet-sen University, NO. 58, Zhongshan Road 2, Yuexiu District, Guangzhou, 510080, China

    Xiaoyun Jiang, Ying Mo & Mengjie Jiang

  3. Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, 3800, Australia

    Jinhua Li

Authors
  1. Aiwen Fan
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  2. Xiaoyun Jiang
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  4. Huizhen Tan
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  5. Mengjie Jiang
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Correspondence to Xiaoyun Jiang.

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Fan, A., Jiang, X., Mo, Y. et al. Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency. Pediatr Nephrol 31, 83–88 (2016). https://doi.org/10.1007/s00467-015-3195-2

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  • DOI: https://doi.org/10.1007/s00467-015-3195-2

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